bis(diisopropylamino)(methyl)phosphine | 110838-39-6

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: bis(diisopropylamino)(methyl)phosphine
• 英文别名: bis (N,N-diisopropylamino)methylphosphine；N,N,N',N'-tetraisopropyl-P-methylphosphonous diamide；N-[[di(propan-2-yl)amino]-methylphosphanyl]-N-propan-2-ylpropan-2-amine
• CAS: 110838-39-6
• 化学式: C₁₃H₃₁N₂P
• 分子量: 246.376
• InChiKey: LHPLDYDXXGGGHK-UHFFFAOYSA-N

物化性质

• 沸点：
  283.0±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis(diisopropylamino)(methyl)phosphine 在 四氯化碳 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以70%的产率得到P-(Dichloromethyl)-N,N,N',N'-tetraisopropylphosphonous Diamide
  参考文献：
  名称：

  Kolodyazhnyi, O. I., Journal of general chemistry of the USSR, 1989, vol. 59, # 2.1, p. 285 - 291

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(diisopropylamino)phosphenium trifluoromethanesulfonate 、 alkaline earth salt of/the/ methylsulfuric acid 以 二氯甲烷 为溶剂， 生成 bis(diisopropylamino)(methyl)phosphine
  参考文献：
  名称：

  Versatile behaviour of the phosphanyl salt (Pri 2N)2 P+CF3SO3 ? towards zirconocene derivatives

  摘要：

  各种基团的转移反应（Ph2P[CH2]3–，Ph2CCPh–CHN–，N3，CN，Me，Cl，H）发生在锆与磷之间，涉及磷阳离子盐(Pri2N)2P+CF3SO3–与锆烯衍生物的反应；(Pri2N)2P–CHN–P(NPri2)28的晶体结构已被确定。

  DOI：

  10.1039/c39930001487

文献信息

• Oligonucleotides comprising a non-phosphate backbone linkage
  申请人：Manoharan Muthiah

  公开号：US20060287260A1

  公开（公告）日：2006-12-21

  One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3′-position. In certain embodiments, the phosphonamidite is an alkyl phosphonamidite. Another aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-phosphate linkage. Representative non-phosphate linkages include phosphonate, hydroxylamine, hydroxylhydrazinyl, amide, and carbamate linkages. In certain embodiments, the non-phosphate linkage is a phosphonate linkage. In certain embodiments, a non-phosphate linkage occurs in only one strand. In certain embodiments, a non-phosphate linkage occurs in both strands. In certain embodiments, a ligand is bound to one of the oligonucleotide strands comprising the double-stranded oligonucleotide. In certain embodiments, a ligand is bound to both of the oligonucleotide strands comprising the double-stranded oligonucleotide. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-phosphate linkage. Representative non-phosphate linkages include phosphonate, hydroxylamine, hydroxylhydrazinyl, amide, and carbamate linkages. In certain embodiments, the non-phosphate linkage is a phosphonate linkage. In certain embodiments, a ligand is bound to the oligonucleotide strand. In certain embodiments, the oligonucleotide comprises at least one modified sugar moiety.

  本发明的一个方面涉及在3'-位置用磷酰胺基团取代的核糖核苷。在某些实施例中，磷酰胺基团是烷基磷酰胺基团。本发明的另一个方面涉及包含至少一个非磷酸酯连接的双链寡核苷酸。代表性的非磷酸酯连接包括磷酸酯、羟胺、羟基肼基、酰胺和碳酸酯连接。在某些实施例中，非磷酸酯连接是磷酸酯连接。在某些实施例中，非磷酸酯连接仅出现在一条链中。在某些实施例中，非磷酸酯连接出现在两条链中。在某些实施例中，配体结合到包含双链寡核苷酸的寡核苷酸链中的一条链上。在某些实施例中，配体结合到包含双链寡核苷酸的寡核苷酸链中的两条链上。在某些实施例中，寡核苷酸链包含至少一个修饰的糖基团。本发明的另一个方面涉及包含至少一个非磷酸酯连接的单链寡核苷酸。代表性的非磷酸酯连接包括磷酸酯、羟胺、羟基肼基、酰胺和碳酸酯连接。在某些实施例中，非磷酸酯连接是磷酸酯连接。在某些实施例中，配体结合到寡核苷酸链上。在某些实施例中，寡核苷酸包含至少一个修饰的糖基团。
• Exploring the coordination chemistry and reactivity of dialkylamino- and bis(dialkylamino)-phosphines in the coordination sphere of metals
  作者：Philip W. Dyer、John Fawcett、Martin J. Hanton、Raymond D. W. Kemmitt、Ranbir Padda、Narendra Singh

  DOI：10.1039/b208886j

  日期：2003.12.20

  [RhCl(CO)2}2] and elemental selenium have been undertaken and the products used to assess the phosphines' donor capabilities. Depending on the substituents at phosphorus, either trans-diphosphine or cis-dicarbonyl complexes result from reaction with [RhCl(CO)2}2]. The sterically demanding phosphine P(NPri2)2Ph (5) proved unreactive towards complexation with metals, although its selenide could be prepared and

  一系列二烷基氨基和双（二烷基氨基）的配位化学-phosphines，R X P（NR' 2）3 - X （X = 1或2; R =氯，甲基中，Ph，C 6 ˚F 5 ; R' = Et，Pr i），1–7，已进行了研究，所得的6族四羰基和二氯化铂双（膦）复杂的特征。随后，与金属结合的PN键的反应性膦类被探测了。R“ OH（R” = Me，Et，烯丙基）双（dialkylaminodiphenylphosphine）与导致NR'的取代无水HCl气体络合物溶液2由OR“; 分离得到的P-烷氧基配合物，收率极高。酸化乙二醇 解决方案 氨基膦配合物得到相应的双（氯二苯基膦）衍生物。以下的反应的反式- [W（CO）4（P 净2 }博士2）2与]任HCl水溶液或H 2 SO 4，反式- [W（CO）4（P OH}博士2）2 ]可以被隔离为二氯甲烷溶剂化物，收率极高（81％）。双（双（二二烷基氨基
• [EN] NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ACIDE NUCLÉIQUE-POLYPEPTIDE ET UTILISATIONS DE CELLES-CI
  申请人：AVIDITY BIOSCIENCES INC

  公开号：WO2020247782A1

  公开（公告）日：2020-12-10

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包括与修饰的多核苷酸分子和聚合物结合的结合基团的组合物和药物配方。本文还描述了利用包括结合基团与多核苷酸分子和聚合物结合的组合物或药物配方治疗癌症的方法。
• Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage
  作者：Anne Lauritsen、Britta M. Dahl、Otto Dahl、Birte Vester、Jesper Wengel

  DOI：10.1016/s0960-894x(02)00882-x

  日期：2003.1

  Synthesis of an oligonucleotide containing one methylphosphonate locked nucleic acid (LNA) thymine monomer using the phosphoramidite approach is described. The binding affinity of this 9-mer methylphosphonate LNA towards complementary DNA and RNA oligonucleotides was increased compared to the reference DNA, but decreased compared to the reference LNA. In the 9-mer sequence context studied, introduction

  描述了使用亚磷酰胺方法合成包含一种甲基膦酸酯锁定的核酸（LNA）胸腺嘧啶单体的寡核苷酸。与参考DNA相比，该9聚体甲基膦酸酯LNA对互补DNA和RNA寡核苷酸的结合亲和力增加，但与参考LNA相比降低。在研究的9-mer序列背景下，与单个LNA单体相反，引入单个甲基膦酸LNA单体可有效抑制3'-外切核酸降解。
• An expeditious route to methylphosphonate analogues of DNA
  作者：E. Kuyl-Yeheskiely、N. J. Meeuwenoord、G. A. van der Marel、J. H. van Boom

  DOI：10.1002/recl.19941130106

  日期：——

  amino groups of both nucleobases adenine and guanine with the N,N-dimethylformamidine and cytosine with the isobutyryl group presents a convenient and economical N-protective-group-strategy for the solid-phase synthesis of DNA fragments containing methylphosphonate linkages at predetermined locations. Thus, the post-synthesis removal of the N-protective groups with hydrazine hydrate (16 h at 20°C) afforded

  用N，N-二甲基甲am保护核苷腺嘌呤和鸟嘌呤的环外氨基，并用异丁酰基保护胞嘧啶，为固相合成含有甲基膦酸酯键的DNA片段提供了一种方便且经济的N保护基策略。预定位置。因此，在合成后用水合肼除去N-保护基团（在20℃下16小时）得到固定的片段，然后将其从固体载体上裂解下来，并通过用甲醇在氨中处理（2小时）在磷上脱保护。在20°C的温度下）以生产高质量的产品。