bis(isopropylcyclopentadienyl)vanadium dichloride | 182759-29-1

• 分子结构分类: 有机化合物 - 碳氢化合物 - 芳香烃
• 英文名称: bis(isopropylcyclopentadienyl)vanadium dichloride
• 英文别名: [(η⁵-C₅H₄ⁱPr)₂VCl₂]；(ⁱPrC₅H₄)₂VCl₂；5-Propan-2-ylcyclopenta-1,3-diene;vanadium(4+);dichloride
• CAS: 182759-29-1
• 化学式: C₁₆H₂₂Cl₂V
• 分子量: 336.198
• InChiKey: IMTQWFSBQPWMPA-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  bis(isopropylcyclopentadienyl)vanadium dichloride 、 聚甘氨酸 以 甲醇 、 水 为溶剂， 以45%的产率得到
  参考文献：
  名称：

  Vanadocene complexes of amino acids bearing functional group in the side chain

  摘要：

  Reaction of Cp2VCl2 with alpha-amino acids bearing functional group in the side chain gives N,O-chelate complexes [Cp2V(N,O-aa)]Cl (aa = ser, thr, asp, glu, asn, gin, lys, arg). These complexes were studied by spectroscopic methods (ESR, IR and Raman). All prepared complexes contain amino acid ligand bonded via oxygen atom of carboxylic group and nitrogen atom of amino group in alpha-position giving five-membered chelate ring. We have observed that hydroxy, amine, carboxylic, amide and guanidinium groups present in alpha-amino acid ligand are not able to coordinate to the central vanadium atom. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.05.020
• 作为产物：
  描述：

  bis(isopropylcyclopentadienyl)vanadium monochloride 在 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 以4.4 g的产率得到bis(isopropylcyclopentadienyl)vanadium dichloride
  参考文献：
  名称：

  Vanadocene complexes of amino acids bearing functional group in the side chain

  摘要：

  Reaction of Cp2VCl2 with alpha-amino acids bearing functional group in the side chain gives N,O-chelate complexes [Cp2V(N,O-aa)]Cl (aa = ser, thr, asp, glu, asn, gin, lys, arg). These complexes were studied by spectroscopic methods (ESR, IR and Raman). All prepared complexes contain amino acid ligand bonded via oxygen atom of carboxylic group and nitrogen atom of amino group in alpha-position giving five-membered chelate ring. We have observed that hydroxy, amine, carboxylic, amide and guanidinium groups present in alpha-amino acid ligand are not able to coordinate to the central vanadium atom. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.05.020

文献信息

• A Facile and Efficient Method for Preparing Ring-Alkylated Vanadocenes (RCp)₂V and Mono- and Dichlorides of Ring-Alkylated Vanadocenes (RCp)₂VCl and (RCp)₂VCl₂
  作者：John A. Belot、Richard D. McCullough、Arnold L. Rheingold、Glenn P. A. Yap

  DOI：10.1021/om960349o

  日期：1996.11.12

  A convenient procedure for the general preparation of bis(methylcyclopentadienyl)vanadium (1), bis(isopropylcyclopentadienyl)vanadium (2), and bis(tert-butylcylopentadienyl)vanadium (3) and their blue monochloride (4-6) and green dichloride (7-9) derivatives is presented. The X-ray structures of compounds 8 and 9 and the electrochemistry and EPR of 7-9 are also presented.
• Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2′-bipyridines and 4,5-diazafluoren-9-one
  作者：Lucie Šebestová、Jaromír Vinklárek、Jan Honzíček、Zdeňka Růžičková、Martina Řezáčová

  DOI：10.1016/j.ica.2014.12.021

  日期：2015.3

  This study describes the synthesis of vanadocene compounds [Cp'2V(L)][OTf](2), where Cp' is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(eta(5)-C5H4Me)(2)V(bpy)][OTf](2), [(eta(5)-(C5H4Pr)-Pr-i)(2)V(bpy)][OTf](2)center dot CH2Cl2, [Cp2V(4,4'-Me-2-bpy)][OTf](2), [Cp2V4,4'-(MeO)(2)-bpy}][OTf](2)center dot MeOH and [(eta(5)-C5H4 Me)(2)V(dafone)][OTf](2) were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performed on human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2'-bipyridine, [(eta(5)-C5H4Me)(2)V(bpy)][OTf](2), that shows IC50 values close to the data observed for cisplatin. (C) 2015 Elsevier B.V. All rights reserved.