6-O-vunylsebacoyl-α-D-glucose

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: 6-O-vunylsebacoyl-α-D-glucose
• 英文别名: 10-O-ethenyl 1-O-[[(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl] decanedioate
• 化学式: C₁₈H₃₀O₉
• 分子量: 390.431
• InChiKey: MZLMUVXSLBZFQA-CUWKQTPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  a-无水葡萄糖酯 、 癸二酸二乙烯酯 在 吡啶 、 alkaline protease 作用下， 生成 6-O-vunylsebacoyl-α-D-glucose
  参考文献：
  名称：

  Electrospun polyacrylonitrile-glycopolymer nanofibrous membranes for enzyme immobilization

  摘要：

  A biocatalyst was fabricated by the covalent immobilization of the enzyme catalase on a polyacrylonitrile (PAN) based nanofibrous membrane incorporating a glycopolymer. The glycopolymer poly-(6-O-vinylsebacoyl D-glucose) [poly-OVSEG] was synthesized by a water phase precipitation homopolymerization process, and its structure was characterized by Fourier transform infrared spectroscopy (FT-IR) and NMR. Composite membranes of PAN/poly-OVSEG nanofibers containing varying amounts (50-70%) of poly-OVSEG were subsequently prepared using electrospinning. The nanofibers were studied by scanning electron microscopy (SEM) and FT-IR. Their hydrophilicity was investigated by measuring water contact angles. With increasing content of poly-OVSEG, the contact angle decreases from 65.5 +/- 2.5 degrees to 15.2 +/- 1.1 degrees. Catalase was immobilized on the composite nanofibrous membranes by covalent binding. The maximum catalase adsorption capacity of the polyacrylonitrile-based nanofibrous membranes was observed to be ca. 46.5 mg/g. Over 50% of catalyst activity was retained and increased thermal stability observed post-immobilization (with maximum activity at pH 7.5 and 50 degrees C). This study demonstrates the potential of using electrospun membranes to improve the thermal and storage stabilities of biological catalysts. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2011.12.003

文献信息

• Highly Anomer- and Regio-selective Transesterification Catalyzed by Alkaline Protease from<i>Bacillus subtilis</i>in Organic Media
  作者：Qi Wu、Deshui Lu、Yongmei Xiao、Shiping Yao、Xianfu Lin

  DOI：10.1246/cl.2004.94

  日期：2004.2

  Highly anomer-selective-6(6')-acylation reactions from anomeric mixtures of several mono- and disaccharides with divinyl dicarboxylates ranging from 4 to 10 carbon atoms were catalyzed by an alkaline protease from Bacillus subtilis in pyridine. A series of new pure α-anomeric polymerisable vinyl sugar esters of dibasic acids were synthesized in good selectivity and yields.

  来自几种单糖和二糖的异头混合物与 4 到 10 个碳原子的二乙烯基二羧酸酯的高度异头选择性 6(6')-酰化反应由来自枯草芽孢杆菌在吡啶中的碱性蛋白酶催化。以良好的选择性和产率合成了一系列新的纯α-异头可聚合二元酸乙烯糖酯。