dichloro-pentyl-phosphine | 15573-32-7

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: dichloro-pentyl-phosphine
• 英文别名: Dichlor-pentyl-phosphin；Dichloro(pentyl)phosphane
• CAS: 15573-32-7
• 化学式: C₅H₁₁Cl₂P
• 分子量: 173.022
• InChiKey: RDLGWAUYRZLYCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloro-pentyl-phosphine 生成 pentylphosphonic dichloride
  参考文献：
  名称：

  Zhmurova,I.N.; Voitsekhovskaya,I.Yu., Journal of general chemistry of the USSR, 1965, vol. 35, p. 2185 - 2187

  摘要：

  DOI：
• 作为产物：
  描述：

  正戊基溴化镁 在 乙醚 、 cadmium(II) chloride 作用下， 生成 dichloro-pentyl-phosphine
  参考文献：
  名称：

  Organophosphorus Compounds. Alkyldichlorophosphines¹

  摘要：

  DOI：

  10.1021/ja01165a085

文献信息

• [EN] PROCESS FOR PREPARING ACYLPHOSPHANES AND DERIVATIVES THEREOF<br/>[FR] PROCEDE DE PREPARATION D'ACYLPHOSPHANES ET DE DERIVES D'ACYLPHOSPHANES
  申请人：CIBA SC HOLDING AG

  公开号：WO2005014605A1

  公开（公告）日：2005-02-17

  The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes of formula (I) n and m are each independently of the other 1 or 2; R1, if n = 1, is e.g. phenyl R1, if n = 2, is e.g. C1-C18alkylene or phenylene; R2 is e. g. C1-C18alkyl, phenyl or substituted phenyl; R3 is e. g. C1-C18alkyl, by (1) reacting a phosphorous halide of formula Ila or a phosphorous halide oxide of formula (Ilb) or a phosphorous halide sulfide of formula (IIc) with an alkali metal in a solvent in the presence of a proton source; (2) subsequent reaction with m acid halides of formula (III) An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono-and bisacylphosphane sulfides.

  本发明涉及一种新的选择性制备式(I)的单酰基和双酰基膦化合物的方法，其中n和m分别独立取1或2；R1，如果n=1，则为例如苯基；如果n=2，则为例如C1-C18烷基或苯基；R2为例如C1-C18烷基、苯基或取代苯基；R3为例如C1-C18烷基，通过以下步骤实现：(1)在溶剂中，在质子源的存在下，将式IIa的磷卤化物或式IIb的磷卤化物氧化物或式IIc的磷卤化物硫化物与碱金属反应；(2)随后与m个式(III)的酸卤化物反应。氧化步骤可能随后进行，以获得单酰基和双酰基膦氧化物或单酰基和双酰基膦硫化物。
• Novel cyclo azaphospha hydrocarbons
  申请人：——

  公开号：US20020177706A1

  公开（公告）日：2002-11-28

  Novel cyclo azaphospha hydrocarbons according to formula I 1 are provided. The compounds are useful as metalloprotease inhibitors.

  根据公式I提供了新型环状氮磷烃化合物。这些化合物可用作金属蛋白酶抑制剂。
• [EN] METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS<br/>[FR] PROCÉDÉS POUR LA RÉDUCTION D'UN OXYDE DE PHOSPHINE DANS DES RÉACTIONS DE WITTIG CATALYTIQUES
  申请人：UNIV DUBLIN CITY

  公开号：WO2014140353A1

  公开（公告）日：2014-09-18

  A method for increasing the rate of phosphine oxide reduction, preferably during a Wittig reaction comprising use of an acid additive is provided. A room temperature catalytic Wittig reaction (CWR) the rate of reduction of the phosphine oxide is increased due to the addition of the acid additive is described. Furthermore, the extension of the CWR to semi-stabilized and non-stabilized ylides has been accomplished by utilization of a masked base and/or ylide-tuning.

  提供了一种增加磷氧化物还原速率的方法，尤其是在Wittig反应中，该方法包括使用酸性添加剂。描述了一种室温催化的Wittig反应（CWR），由于添加了酸性添加剂，磷氧化物还原的速率得到了提高。此外，通过利用掩蔽碱和/或调节基团，CWR已成功扩展到半稳定和不稳定的亚磷酰化物。
• Flash vacuum pyrolysis of dichlorophosphines over magnesium: Generation and reactivity of simple phosphinidenes
  作者：R.Alan Aitken、Wayiza Masamba、Neil J Wilson

  DOI：10.1016/s0040-4039(97)10236-2

  日期：1997.12

  Flash vacuum pyrolysis of dichlorophosphines over magnesium at 500–600 °C gives the products expected from intramolecular CH insertion of the corresponding phosphinidenes.

  在500–600°C的条件下，在镁上进行快速真空热裂解二氯膦，得到相应的次膦亚基分子内CH插入所需的产物。
• [EN] METHODS FOR FORMING 1,3,5,7-TETRAALKYL-6-(2,4-DIMETHOXYPHENYL)-2,4,8-TRIOXA-6-PHOSPHAADAMANTANE<br/>[FR] PROCÉDÉS DE FORMATION DE 1,3,5,7-TÉTRAALKYL-6-(2,4-DIMÉTHOXYPHÉNYL)-2,4,8-TRIOXA-6-PHOSPHAADAMANTANE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2018175671A1

  公开（公告）日：2018-09-27

  A method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane includes obtaining a solution comprising an ethereal solvent and an aluminum hydride, adding dichloro(2,4-dimethoxyphenyl)phosphine to the solution to produce 2,4-dimethoxyphenylphosphine, and reacting the 2,4-dimethoxyphenylphosphine with an acidic mixture comprising diones to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane. The solution has a temperature from greater than -20 C to 50 C throughout the method. Another method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane includes obtaining dichloro(2,4-dimethoxyphenyl)phosphine, forming 2,4-dimethoxyphenylphosphine by adding the dichloro(2,4-dimethoxyphenyl)phosphine to a solution comprising at least one solvent and an aluminum hydride, reacting the 2,4-dimethoxyphenylphosphine with a mixture to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane. The mixture includes an acid selected from the group consisting of Lewis acids, sulfonic Bronsted acids, and mixtures thereof, an aromatic or non-aromatic hydrocarbons; and acetylacetone.

  一种形成1,3,5,7-四烷基-6-(2,4-二甲氧基苯基)-2,4,8-三氧杂-6-磷氮金刚烷的方法包括获得包含乙醚溶剂和铝氢化物的溶液，向溶液中添加二氯(2,4-二甲氧基苯基)膦生成2,4-二甲氧基苯基膦，并将2,4-二甲氧基苯基膦与含二酮的酸性混合物反应以生成1,3,5,7-四烷基-6-(2,4-二甲氧基苯基)-2,4,8-三氧杂-6-磷氮金刚烷。整个方法中，溶液的温度从-20摄氏度到50摄氏度。另一种形成1,3,5,7-四烷基-6-(2,4-二甲氧基苯基)-2,4,8-三氧杂-6-磷氮金刚烷的方法包括获得二氯(2,4-二甲氧基苯基)膦，通过将二氯(2,4-二甲氧基苯基)膦加入至至少一种溶剂和铝氢化物的溶液中形成2,4-二甲氧基苯基膦，将2,4-二甲氧基苯基膦与混合物反应以生成1,3,5,7-四烷基-6-(2,4-二甲氧基苯基)-2,4,8-三氧杂-6-磷氮金刚烷。该混合物包括从Lewis酸、磺酸Bronsted酸和它们的混合物中选择的酸，芳香或非芳香烃以及乙酰丙酮。