CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on the lack of carcinogenicity data in animals and humans. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: None.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
神经毒素 - 感觉运动
Neurotoxin - Sensorimotor
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Studies have been made of the effect of inhibitors of energy metabolism on maintenance of Na and K concentrations, as well as on accumulation of Rb (as an analogue of K) in single neurones of the mollusk Planorbarius corneus. Monovalent thallium which is capable of inhibiting the respiratory chain and destroying mitochondrial structure, significantly inhibited Rb accumulation in the neurones. The decrease in accumulation of Rb by monoiodoacetate and thallium nitrate was less significant as compared with that produced by a specific blocker of Na/K-pump, ouabain.
The following medical procedures should be made available to each employee who is exposed to ... thallium /and thallium/ compounds at potentially hazardous levels: Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the eyes, nervous system, lung, liver, kidneys, gastrointestinal tract, and body hair should be stressed. Urinalysis: Since kidney damage has been observed in humans exposed to thallium, a urinalysis should be obtained to include at a minimum specific gravity, albumin, glucose, and a microscopic /examination/ on centrifuged sediment. Periodic Medical Examination: These medical examinations should be repeated on an annual basis. /Thallium and thallium compounds/
A CASE IS DESCRIBED OF SEVERE POISONING WITH THALLIUM NITRATE IN AN ATTEMPT AT SUICIDE, ACCOMPANIED BY TEMPORARY LESION OF THE KIDNEYS & LIVER & TEMPORARY TOXIC NEUROPATHY OF OCULAR NERVE WITH SUBSEQUENT POLYNEUROPATHY LASTING OVER 1 1/2 YR AFTER THE POISONING. THE LIVER LESION OCCURRED DURING THE COURSE OF THE ILLNESS. IT WAS MANIFESTED BY HEPATOMEGALY & AN INCREASE IN GOT & GPT VALUES. THE PATIENT EXCRETED IN THE URINE 494.512 MG OF THALLIUM OVER A 15 WK COURSE OF TREATMENT. MICROSCOPIC EXAMINATION OF THE PATIENT'S HAIR DURING THE COURSE OF THE FIRST WK OF POISONING DEMONSTRATED DEPOSITION OF MELANIN PIGMENT IN THE ROOTS, WHICH DECREASED DURING THE COURSE OF TREATMENT. THIS SIMPLE, ORIENTATIONAL STUDY CAN SERVE TO SUPPLEMENT THE DIAGNOSIS OF THALLIUM POISONING.
IN /RATS GIVEN THALLIUM NITRATE/ ... EXCRETION OF (204)THALLIUM MAINTAINED SIMILAR PATTERN REGARDLESS OF ROUTE OF ADMIN. ABOUT 6% ... HAD BEEN EXCRETED IN URINE AFTER 1 DAY, EXCRETION FALLING TO ABOUT 0.5% BY 10TH DAY. ... FECAL EXCEEDED URINARY EXCRETION DURING THE 21 DAYS ... FECAL TO URINARY RATIO RISING FROM 2 TO 5.
A CASE IS DESCRIBED OF SEVERE POISONING WITH THALLIUM NITRATE IN AN ATTEMPT AT SUICIDE. THE PATIENT EXCRETED IN THE URINE 494.512 MG OF THALLIUM OVER A 15 WK COURSE OF TREATMENT.
THE DISTRIBUTION OF THALLIUM WAS DETERMINED IN 57 AUTOPSIED TISSUES, INCL BLOOD, OF A PATIENT WHO HAD BEEN ORALLY ADMIN 500 mCi THALLOUS NITRATE (TlNO3) FOLLOWED BY ... 45 MG DOSES ... THALLIUM(I) SULFATE (Tl2SO4) ... UNTIL 225 MG HAD BEEN GIVEN. THE BLOOD SHOWED A RAPID RISE WITHIN 2 HR TO A LEVEL OF 3% OF THE ADMIN RADIOISOTOPE ... TO 1.6%. SOME SPECIFIC LOCALIZATION OF THALLIUM ... WAS FOUND IN THE SCALP HAIR, KIDNEYS, HEART MUSCLE, PRIMARY BONE TUMOR, AND SPLEEN, IN THAT DECREASING ORDER. ... CLOSELY FOLLOWED BY ADRENAL MEDULLA, BONE TUMOR FROM LUNG, PANCREAS, SCALP SKIN, AND LIVER, RIB MARROW, THYROID, ADRENAL CORTEX, AND PITUITARY. ... A DIFFERENT DISTRIBUTION PICTURE WAS FOUND IN THE RAT ... INJECTED WITH 23 UG TlNO3. ... 2 DAYS AFTER DOSING, THE KIDNEYS CONTAINED THE HIGHEST CONCN FOLLOWED BY THE GUT, GONADS, AND PANCREAS. ... THESE DIFFERENCES IN LOCALIZATION OF THALLIUM SUGGEST CAUTION IN TRANSLATING RESULTS OBTAINED IN ANIMALS TO MAN.
... GAVE RADIOACTIVE THALLOUS NITRATE & THALLOUS SULFATE ORALLY TO 1 PT WITH METASTATIC OSTEOGENIC SARCOMA & FOUND RATE OF EXCRETION IN URINE TO BE 3.2% PER DAY OF AMOUNT REMAINING IN BODY. THALLIUM EXCRETION IN BOTH URINE & FECES MAY PERSIST FOR MANY WEEKS IN SPITE OF LOW PLASMA LEVELS IN POISONED PATIENTS.
Structure Lattice-Dimensionality and Spectroscopic Property Correlations in Novel Binary and Ternary Materials of Group 13 Elements with α-Hydroxycarboxylic Benzilic Acid and Phenanthroline
作者：E. Halevas、A. Hatzidimitriou、M. Bertmer、A. A. Vangelis、A. Antzara、C. Mateescu、A. Salifoglou
DOI：10.1021/cg500638z
日期：2014.8.6
To probe and understand the structural and coordinative flexibility of Group 13 ions with α-hydroxycarboxylic acids, leading to crystalline inorganic–organic hybrid materials with distinct lattice architecture, dimensionality, and spectroscopic properties, the systematic synthesis and physicochemical properties of binary and ternary B(III), Al(III), Ga(III), In(III), and Tl(I)-benzilic acid-(phenanthroline)
为了探查和理解第13族离子与α-羟基羧酸的结构和配位灵活性，从而导致具有独特的晶格结构，尺寸和光谱性质的结晶无机-有机杂化材料，对二元和三元B（系统地合成和理化性质）进行了研究。 III），Al（III），Ga（III），In（III）和Tl（I）-苯甲酸-（菲咯啉）体系在水-醇混合物中进行了研究。第13组离子与苯甲酸和菲咯啉（phen）的化学计量反应提供了新材料[B（C 14 H 10 O 3）2 ]（C 3 H 5 N 2）·H 2 O（1），[Al（C 14 H 11 O 3）3 ]·0.5C 2 H 5 OH·4.5H 2 O（2），[Ga（C 14 H 11 O 3）3 ]·CH 3 OH·3H 2 O （3），[In（C 14 H 11 O 3）4 ]·C 3 H 5 N 2 ·C 2 H 5 OH·H 2 O（4），[Tl（C 14 H 11O 3）] n（5），[Tl 2（C
Cooperative metal–ligand influence on the formation of coordination polymers, and conducting and photophysical properties of Tl(<scp>i</scp>) β-oxodithioester complexes
作者：Chote Lal Yadav、Gunjan Rajput、Krishna K. Manar、Kavita Kumari、Michael G. B. Drew、Nanhai Singh
DOI：10.1039/c8dt03694b
日期：——
considering the metal-assisted bonding interactions, various coordination numbers of 5–8 and 10 are established around the metal centre. Except for 5 and 7a which have Tl⋯Tl separations at 3.724(1) and 3.767(1), 3.891(1) Å respectively, the remaining complexes have no Tl⋯Tl distances <4.0 Å. This indicates that the majority of structures contain only weak inter- and intramolecular thallophilic interactions
八个新颖的Tl（I）β-氧二硫代酯络合物[TlL] n（1–8），带有配体，L = 3-羟基-3-（2-呋喃基）-2-丙二硫代乙酸甲酯（L1），甲基3 -羟基-3-（2-噻吩基）-2-丙二硫代酸酯（L2），甲基3-羟基-3-（3-吡啶基）-2-丙二硫代酸酯（L3），-3-羟基-3-（4-甲基）吡啶基）-2-丙二硫代酸酯（L4），-3-羟基-3-（9-蒽基）-2-丙二硫代甲酸甲酯（L5），-3-羟基-3-（4-氟苯基）-2-丙二硫代甲酸甲酯（L6 ）合成了3-羟基-3-（4-氯苯基）-2-丙二硫代酸甲酯（L7）和3-羟基-3-（4-溴苯基）-2-丙二硫代酸甲酯（L8），并进行了彻底表征元素分析，IR，UV-Vis，1 H和13 C 11 H NMR光谱及其结构通过X射线晶体学确定。络合物1和2中结晶P 2 1和P 2个1 2 1 2 1分别手性的空间群，以及使用圆二色性（CD）光谱进行了
Substituted sulfonamides, process of preparation and medicines
申请人：Lipha Lyonnaise Industrielle Pharmaceutique
公开号：US05387709A1
公开（公告）日：1995-02-07
The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts possibly in the form of complexes, esters and amides thereof, represented by the formula: ##STR1##
Abstract Using an isoperibol twin-dewar solution calorimeter, the enthalpies of reaction of thallous styphnate and the half-acid salt of thallous styphnate were determined as +64.56 and +26.80 kJ mol −1 , respectively, which with various ancillary data give the standard enthalpies of formation of −527.56 and −492.05 kJ mol −1 , respectively.
Li[t-BuB(pz(t-Bu))2(mu-OH)]}2 (4). The crystalstructure of 4 shows two Li cations encapsulated by the heteroscorpionate [t-BuB(OH)(3-t-Bupz)2]- ligands. A salt elimination reaction between FeCl2(THF)1.5 and 2 equiv of Li[t-BuTp(R)] (R = H, Me) followed by an in situ one-electron oxidation produced good yields of the homoleptic, paramagnetic low-spin iron(III) complexes [Fe(t-BuTp)2]PF6 (5) and [Fe(t-BuTp(Me))2]PF6
