2-N-[[2-[bis(cyclopropylmethyl)amino]-8-methylquinolin-3-yl]methyl]-2-N-[[3-(fluoromethyl)-5-(trifluoromethyl)phenyl]methyl]-4-N,4-N-dimethyl-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-N-[[2-[bis(cyclopropylmethyl)amino]-8-methylquinolin-3-yl]methyl]-2-N-[[3-(fluoromethyl)-5-(trifluoromethyl)phenyl]methyl]-4-N,4-N-dimethyl-1,3,5-triazine-2,4-diamine
• 化学式: C₃₃H₃₇F₄N₇
• 分子量: 607.7
• InChiKey: ONMYLBUTTNEXJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• [EN] PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES D'INHIBITEURS CETP
  申请人：REDDYS LAB LTD DR

  公开号：WO2014128564A2

  公开（公告）日：2014-08-28

  The present application discloses a pharmaceutical composition comprising a class of cholesteryl ester transfer protein (CETP) inhibitors with improved oral bioavailability. The application further discloses compositions comprising a class of CETP inhibitor and at least one surfactant in the form of a solution, suspension, emulsion or a pre-concentrate.