Monocalcium phosphate phosphoric acid

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: Monocalcium phosphate phosphoric acid
• 英文别名: calcium;hydrogen phosphate;phosphoric acid
• 化学式: CaH4O8P2
• 分子量: 234.05
• InChiKey: YYRMJZQKEFZXMX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

ADMET

代谢

磷酸盐代谢缺陷发生在多种疾病中。... 骨质疏松症 ... 佝偻病 ... 骨软化症 ... 纤维性骨炎囊肿病 ... 第二性甲状旁腺功能亢进 ... 甲状旁腺功能减退 ... . /磷酸盐/

A defect in phosphate metabolism occurs in a variety of diseases. ... Osteoporosis ... Rickets ... Osteomalacia ... Osteitis Fibrosa Cystica ... Secondary Hyperparathyroidism ... Hypoparathyroidism ... . /Phosphates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

眼部刺激和由接触肥料导致的角膜烧伤可归因于游离磷酸或从过磷酸钙中释放出的磷酸... 钙过磷酸盐颗粒特征性地引起局部蓝白色角膜混浊，最终会自行清除。

... OCULAR IRRITATION & CORNEAL BURNS CAUSED BY CONTACT WITH FERTILIZERS WERE ATTRIBUTABLE ...TO FREE PHOSPHORIC ACID OR PHOSPHORIC ACID LIBERATED FROM SUPERPHOSPHATE ... PARTICLES OF CALCIUM SUPERPHOSPHATE CHARACTERISTICALLY APPEARED TO CAUSE LOCALIZED BLUISH-WHITE CORNEAL OPACITIES WHICH EVENTUALLY CLEARED.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

...摄入超过2克/公斤的剂量才可能引起刺激和毒性反应。皮肤致敏不常见。吸入或吞咽可能会引起化学性肺炎。植入会导致异物反应。/磷酸钙/

... NOT IRRITATING & TOXIC DOSES BY INGESTION WOULD HAVE TO BE IN EXCESS OF 2 G/KG. ... SKIN SENSITIZATION IS UNUSUAL. ASPIRATION OR INHALATION ... COULD CAUSE CHEM PNEUMONITIS. IMPLANTATION ... WILL CAUSE FOREIGN BODY REACTION. /CALCIUM PHOSPHATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在羊摄入18%的过磷酸钙和牛摄入30%的超磷酸钙后，血清中多种成分的定量变化以及尿液中磷酸盐和氟离子的排泄增加。羊还出现了临时的腹泻和体重减轻。

QUANTATIVE CHANGES IN SEVERAL SERUM COMPONENTS & INCR URINARY EXCRETION OF PHOSPHATES & FLUORIDE IONS OCCURRED AFTER INGESTION OF 18% CALCIUM SUPERPHOSPHATE IN SHEEP & 30% CALCIUM HYPERPHOSPHATE IN CALF. TEMPORARY DIARRHEA & WT LOSS ALSO OCCURRED IN SHEEP.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在大鼠中，钙2+吸收的抑制作用是磷酸盐剂量的函数，直到达到一个值，超过这个值就不再观察到额外的抑制效果。

IN RATS INHIBITION OF CALCIUM 2+ ABSORPTION WAS FUNCTION OF PHOSPHATE DOSE UNTIL A VALUE WAS REACHED ABOVE WHICH NO ADDITIONAL INHIBITORY EFFECT WAS OBSERVED.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

磷酸盐的有效/膳食/水平通常为0.5%或更少。当这一水平……被许多动物在饮食中摄入时，已被证实为非毒性。/磷酸盐/

THE EFFECTIVE /DIETARY/ LEVELS OF PHOSPHATES ARE USUALLY 0.5% OR LESS. WHEN THIS LEVEL ... WAS CONSUMED IN DIETS OF MANY ANIMALS, IT WAS SHOWN TO BE NONTOXIC. /PHOSPHATES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

/Ortho/ 磷酸盐从胃肠道中被吸收，并且在一定程度上被分泌到胃肠道中。从肠道腔内运输磷酸盐是一个积极的、依赖能量的过程，并且有一些因素似乎会改变其肠吸收的程度。... 维生素D刺激磷酸盐的吸收，据报道，这种效果先于维生素对钙离子运输的作用。一般来说，在成年人中，大约三分之二的摄入磷酸盐从肠道中被吸收，而吸收自肠道的几乎全部通过尿液排出。在成长中的儿童中，磷酸盐的平衡是正的。儿童血浆中的磷酸盐浓度高于成年人。这种“高磷血症”降低了血红蛋白对氧气的亲和力，并且假设这可以解释儿童生理上的“贫血”。/磷酸盐/

/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. The transport of phosphate from the lumen of the gut is an active, energy-dependent process, and there are factors that appear to modify the degree of its intestinal absorption. ... Vitamin D stimulates phosphate absorption, and this effect has been reported to precede the action of the vitamin on transport of calcium ion. In general, in adults, about two thirds of the ingested phosphate is absorbed from the bowel, and that which is absorbed from the gut is almost entirely excreted into the urine. In growing children, there is a positive balance of phosphate. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  Monocalcium phosphate phosphoric acid 生成 calcium hydrogen phosphate
  参考文献：
  名称：

  REDEPENNING, JODY;MCISAAC, JOSEPH P., CHEM. MATER., 2,(1990) N, C. 625-627

  摘要：

  DOI：
• 作为产物：
  描述：

  磷酸钙粉末 生成 Monocalcium phosphate phosphoric acid
  参考文献：
  名称：

  NISHINO, TADASHI, SEHKKO TO SEHKKAJ,(1989) N19, S. 88-95

  摘要：

  DOI：
• 作为试剂：
  描述：

  磷酸 、 氢氧化钙 在 calcium hydrogen phosphate 、 Monocalcium phosphate phosphoric acid 作用下， 生成 Monocalcium phosphate phosphoric acid
  参考文献：
  名称：

  Mineral Additive for a Dietary Composition for Animals and Method for the Production Thereof

  摘要：

  本发明涉及一种用于动物饲料配方的添加矿物质，包括至少一种磷酸盐和一种能与之形成盐的化合物，以生物可消化的形式存在。该添加剂以水溶液的形式存在，其中盐处于溶解状态，并以磷酸盐离子和该化合物离子的形式提供。本发明还涉及一种生产该添加剂的方法和一种用于执行该方法的装置。

  公开号：

  US20090053356A1

文献信息

• Mineral additive for a dietary composition for animals and method for the production thereof
  申请人：Takhim Mohamed

  公开号：US08951587B2

  公开（公告）日：2015-02-10

  The invention relates to an additive mineral for a dietary composition for animals comprising, in a biodigestible form, at least one phosphoric acid salt and a compound capable of forming a salt therewith. The additive is in the form of an aqueous solution in which the salt is in a dissolved state and is provided in the form of phosphate ions and of ions of said compound. The invention also relates to a method for producing the additive and to a device for carrying out this method.

  该发明涉及一种用于动物饲料组成的添加矿物质，包括至少一种磷酸盐和一种能够与其形成盐的化合物，以生物可消化的形式存在。该添加剂以水溶液形式存在，其中盐以溶解状态提供，以磷酸盐离子和该化合物的离子形式存在。该发明还涉及一种生产该添加剂的方法以及一种用于执行该方法的装置。
• METHOD FOR PRODUCING POROUS CALCIUM PHOSPHATE BODY, AND POROUS CALCIUM PHOSPHATE BODY PRODUCED THEREBY
  申请人：JNC CORPORATION

  公开号：US20150152573A1

  公开（公告）日：2015-06-04

  To provide a method for producing a porous calcium phosphate body having open micropores. A porous calcium phosphate body having open and uniform micropores can be produced by the method for producing the porous calcium phosphate body, in which calcium phosphate is subjected to electrospinning.

  提供一种制备具有开放微孔的多孔磷酸钙体的方法。通过对磷酸钙进行电纺处理，可以制备出具有开放且均匀微孔的多孔磷酸钙体。
• EDWARDS, RONALD E.;MOORE, OSCAR E.;HODGE, CHARLES A., IND. AND ENG. CHEM. RES., 28,(1989) N, C. 329-334
  作者：EDWARDS, RONALD E.、MOORE, OSCAR E.、HODGE, CHARLES A.

  DOI：——

  日期：——
• ALOSMANOV, M. S.;KOPYLEV, B. A.;IBRAGIMOVA, S. M.;DZHAFAROV, A. P.;KULIEV+, ISSLED. V OBL. PR-BA UDOBR., L.,(1989) S. 42-48
  作者：ALOSMANOV, M. S.、KOPYLEV, B. A.、IBRAGIMOVA, S. M.、DZHAFAROV, A. P.、KULIEV+

  DOI：——

  日期：——
• BRODSKIJ, A. A.;VARFOLOMEEV, V. A.;DOBRYDNEV, E. P.;EPIFANOVA, O. M.;YANI+
  作者：BRODSKIJ, A. A.、VARFOLOMEEV, V. A.、DOBRYDNEV, E. P.、EPIFANOVA, O. M.、YANI+

  DOI：——

  日期：——