ZINC chlorate | 10361-95-2

• 物质功能分类: 无机化工 - 无机盐 - 金属卤化物及卤酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 英文名称: ZINC chlorate
• 英文别名: zinc;dichlorate
• CAS: 10361-95-2
• 化学式: Zn(ClO3)2
• 分子量: 232.3
• InChiKey: GTQFPPIXGLYKCZ-UHFFFAOYSA-L

物化性质

• 熔点：
  decomposes at 60℃ [HAW93]
• 密度：
  2.150
• 物理描述：
  Zinc chlorate appears as a white crystalline solid. May explode under prolonged exposure to heat or fire.
• 颜色/状态：
  Yellow crystals
• 溶解度：
  Very soluble in water
• 分解：
  The tetrahydrated salt /of zinc chlorate/ decomp explosively at 60 °C.

计算性质

• 辛醇/水分配系数(LogP)：
  -7.14
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

锌可以通过肺部、皮肤和胃肠进入人体。肠道对锌的吸收由锌载体蛋白CRIP控制。锌还与金属硫蛋白结合，帮助防止过量锌的吸收。锌广泛分布并在所有组织和组织液中找到，特别是在肝脏、胃肠道、肾脏、皮肤、肺、大脑、心脏和胰腺中含量较高。在血液中，锌存在于红细胞中的碳酸酐酶结合中，以及血浆中的白蛋白、α2-巨球蛋白和氨基酸结合中。白蛋白和氨基酸结合的锌可以扩散穿过组织膜。锌通过尿液和粪便排出体外。

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

缺铁性贫血是由于锌的过量吸收抑制了铜和铁的吸收，这很可能是通过肠道粘膜细胞的竞争性结合实现的。铜和锌与铜锌超氧化物歧化酶的不平衡水平已被与肌萎缩侧索硬化症（ALS）联系在一起。胃酸能溶解金属锌，生成腐蚀性的氯化锌，这可能会对胃壁造成损害。金属烟雾热被认为是对吸入锌的免疫反应。（L48, L49, A49）

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

长期接触锌会导致贫血、共济失调、乏力，并降低体内良好胆固醇的水平。还认为它会导致胰腺和生殖损伤。

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入（L49）；口服（L49）；皮肤给药（L49）

Inhalation (L49) ; oral (L49) ; dermal (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

大量摄入锌会导致胃痉挛、恶心和呕吐。急性吸入大量锌会导致金属烟雾热，其特点是寒战、发热、头痛、乏力、鼻和喉咙干燥、胸痛和咳嗽。锌与皮肤的接触会导致皮肤刺激。

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

来源:Toxin and Toxin Target Database (T3DB)

吸收、分配和排泄

氯酸盐可以通过摄入或吸入粉尘被吸收。

... CHLORATES ARE ... ABSORBED BY INGESTION OR BY INHALATION OF DUST. /CHLORATES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

静脉注射锌后，锌会分布到红细胞、血浆和白细胞中；血液中大约80%的锌存在于红细胞中，12-20%在血浆中，大约3%在白细胞中。血浆和红细胞之间存在锌的动态交换。吸入锌盐的尘埃会在被吸收进入血液之前在肺部暂时积聚。锌或其盐类通过皮肤的吸收很少。大约80%的锌通过静脉给药后通过粪便排出，这表明锌有一个肠肝循环。在人类中，大约10%的吸收的锌通过尿液排出，在热带气候中，每天大约有2-3毫克的锌可能通过汗液丢失。/可溶性锌化合物/

Upon intravenous injection zinc is distributed to erythrocytes, plasma, and leukocytes; about 80% of the zinc present in the blood is found in the erythrocytes, 12-20% in the plasma, and about 3% in the leukocytes. ... There is a dynamic exchange of zinc between plasma and erythrocytes. Inhalation of dusts of zinc salts results in a transient accumulation in the lung before its absorption into the blood. There is little absorption of zinc or its salts through the skin. ... About 80% of parenterally administered zinc is excreted in the feces, suggesting an enterohepatic circulation for zinc. In humans, about 10% of the absorbed zinc is excreted in the urine, and in tropical climates about 2-3 mg zinc/day may be lost in sweat. /Soluble zinc compounds/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  5.1
• 危险品运输编号：
  1513
• WGK Germany：
  2
• 包装等级：
  II
• 危险类别：
  5.1
• 安全说明：
  S24/25

制备方法与用途

水中溶解度(g/100ml)在不同温度(℃)时每100毫升水中的溶解克数如下：

• 0℃：145g
• 10℃：152g
• 20℃：209g
• 30℃：223g

生产方法为： 将等摩尔的硫酸锌溶液和氯酸钡溶液混合，然后过滤并进行离心分离，得到不含硫酸钡悬浮物的澄清溶液。将此溶液浓缩以析出结晶，并由于晶体易吸湿，需使用五氧化二磷在真空条件下干燥两天。