Diazanium;tetrachloropalladium;dichloride

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 英文名称: Diazanium;tetrachloropalladium;dichloride
• 化学式: Cl6H8N2Pd
• 分子量: 355.2
• InChiKey: LOLIPEAFAJNGJM-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  2
• 氢给体数：
  2
• 氢受体数：
  1

ADMET

代谢

钯可能通过口服、皮肤接触和吸入暴露而被吸收。一旦进入体内，它会分布到肾脏、肝脏、脾脏、淋巴结、肾上腺、肺和骨骼中。钯能够形成络合物，这使得它能够与氨基酸、蛋白质、DNA和其他大分子结合。钯及其代谢物通过尿液和粪便排出体外。(A21)

Palladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium's ability to form complexes allows it the bind to amino acids, proteins, DNA, and other macromolecules. Palladium and its metabolites are excreted in the urine and faeces. (A21)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

由于钯离子能够与无机和有机配体形成稳定的络合物，它们可以干扰细胞平衡，取代其他必需离子，并与大分子如蛋白质或DNA的功能团发生相互作用。与DNA和RNA结合的钯络合物会导致链断裂。钯离子能够抑制大多数主要的细胞功能，包括DNA和RNA的合成。钯化合物已被证明能够结合并抑制多种酶，包括肌酸激酶和脯氨酰羟化酶。

Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. (L798)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

与钯接触可能会导致钯敏感和过敏。动物研究显示钯可能会对肝脏和肾脏造成损害。

Contact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (L798)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

皮肤接触钯可能会导致接触性皮炎、红斑和水肿。

Skin contact with palladium may cause contact dermatitis, erythema, and oedema. (L798)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露处理

眼睛：用清水冲洗睁开的眼睛几分钟。摄入：不要催吐。用水漱口（永远不要给无意识的人口服任何东西）。寻求立即的医疗建议。皮肤：应立即用流动的冷水冲洗受影响的部位至少15分钟，然后用肥皂和水彻底清洗。如有必要，该人员应淋浴并更换受污染的衣服和鞋子，然后必须寻求医疗注意。吸入：提供新鲜空气。如有必要，提供人工呼吸。

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  Diazanium;tetrachloropalladium;dichloride 、 disodium;carbonate 生成 Disodium;dichloropalladium;dichloride
  参考文献：
  名称：

  RYUMIN A. I.; SMIRNOV I. I.; BIZYUKINA N. V.; KRAPIVKO A. A., IZV. VUZOV. TSV. METALLURGIYA,(1986) N 4, 62-65

  摘要：

  DOI：

文献信息

• Tobacco composition
  申请人：Liggett Group Inc.

  公开号：US04248251A1

  公开（公告）日：1981-02-03

  The concentration of polycyclic aromatic hydrocarbons in tobacco smoke is reduced by incorporating palladium, either in metallic form or as a salt, and an inorganic nitric oxide generating compound into tobacco.

  将钯（以金属形式或盐形式）和无机制造一氧化氮化合物加入烟草中，可以降低烟草烟雾中多环芳烃的浓度。
• RYUMIN A. I.; SMIRNOV I. I.; BIZYUKINA N. V.; KRAPIVKO A. A., IZV. VUZOV. TSV. METALLURGIYA,(1986) N 4, 62-65
  作者：RYUMIN A. I.、 SMIRNOV I. I.、 BIZYUKINA N. V.、 KRAPIVKO A. A.

  DOI：——

  日期：——