Arsinyl | 2163-80-6

• 物质功能分类: 化学农药原药 - 除草剂 - 其他除草剂
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Arsinyl
• 英文别名: sodium;methylarsonic acid
• CAS: 2163-80-6；144-21-8
• 化学式: CH5AsNaO3+
• 分子量: 162.96
• InChiKey: JITOKQVGRJSHHA-UHFFFAOYSA-N

物化性质

• 熔点：
  >355 °C
• 沸点：
  165°C
• 密度：
  1.1500
• 溶解度：
  轻微溶于水
• 颜色/状态：
  White solid
• 气味：
  None
• 蒸汽压力：
  1X10-5 Pa @ 25 °C (7.8X10-8 mm Hg)
• 稳定性/保质期：
  STABLE TO HYDROLYSIS
• 分解：
  When heated to decomposition it emits toxic fumes of /arsenic and sodium oxide/.
• 腐蚀性：
  NON-CORROSIVE TO IRON, RUBBER, & MOST PLASTICS
• 解离常数：
  pKa1= 4.1; pKa2 = 9.02

计算性质

• 辛醇/水分配系数(LogP)：
  -4.03
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

ADMET

代谢

单钠甲酸砷在豆类中的降解...提取中回收的砷有3-5%仍然结合在不可溶残留物中。...剩余残留物...大约60%与一种ninhydrin-POS物质（RF=0.69）相关联，而40%是不络合的MSMA（RF=0.35）。...单钠甲酸砷对棉花的处理。在72小时的植物暴露期间几乎没有或没有代谢...棉花显然在处理后的至少72小时内不形成络合物。/组氨酸络合物在其他植物中已被提出，但尚未被证实。

... DEGRADATION OF MONOSODIUM METHANEARSONATE IN BEANS ... 3-5% OF ARSENIC RECOVERED IN EXTRACT REMAINED BOUND TO INSOL RESIDUE. ... OF REMAINING RESIDUE ... ABOUT 60% WAS ASSOCIATED WITH A NINHYDRIN-POS SUBSTANCE (RF= 0.69) WHILE 40% WAS UNCOMPLEXED MSMA (RF= 0.35). ... MONOSODIUM METHANEARSONATE ON COTTON. LITTLE OR NO METAB...DURING 72 HR PLANT EXPOSURE. ... COTTON APPARENTLY FORMS NO COMPLEX, @ LEAST WITHIN 72 HR AFTER TREATMENT. /HISTIDINE COMPLEX PROPOSED, BUT NOT PROVEN, IN OTHER PLANTS/

来源:Hazardous Substances Data Bank (HSDB)

代谢

松树抗药性的持续时间对于亚砷酸甲钠来说比cacodylic acid( cacodylic acid)要长得多，这可能是由于添加了将亚砷酸甲钠转化为cacodylic acid的代谢步骤。。没有甲基化证据。

RESISTANCE TO ENTRY OF PINUS PONDEROSA WAS SUBSTANTIALLY MORE PROLONGED FOR MONOSODIUM METHANEARSONATE THAN FOR CACODYLIC ACID WHICH MAY BE RESULT OF ADDED METABOLIC STEP NECESSARY TO CONVERT MONOSODIUM METHANEARSONATE TO CACODYLIC ACID. ... NO PROOF OF METHYLATION ... OFFERED.

来源:Hazardous Substances Data Bank (HSDB)

代谢

志愿者摄入了一剂500毫克的砒霜，以亚砷酸钠的形式。四天后，摄入的砒霜中有78%通过尿液排出。亚砷酸被甲基化成13%的二甲胂酸盐。/亚砷酸，二钠盐/

VOLUNTEERS INGESTED A SINGLE ORAL DOSE OF 500 MG ARSENIC AS DISODIUM METHANEARSONATE. AFTER 4 DAYS, 78% OF INGESTED ARSENIC WAS EXCRETED IN URINE. METHANEARSONATE IS 13% METHYLATED INTO DIMETHYLARSINATE. /METHANEARSONIC ACID, DISODIUM SALT/

来源:Hazardous Substances Data Bank (HSDB)

代谢

...DSMA...在...植物中的反应...单个放射性化合物...在紫花莎草（莎草科圆莎草属）的热80%乙醇提取物中发现。化学分析显示C-As键保持完整。/甲基肿酸，二钠盐/

REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT. /METHANEARSONIC ACID, DISODIUM SALT/

来源:Hazardous Substances Data Bank (HSDB)

代谢

... 检查了DSMA的化学反应产物 ... 在紫色香附子（莎草科莎草属植物）。... 从（14）C DSMA处理的植物中呼吸的二氧化碳中检测到放射性，表明C-As键降解。/甲基亚砷酸，二钠盐/

... EXAMINED REACTION PRODUCTS OF DSMA ... IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS L). ... RADIOACTIVITY WAS ... DETECTED IN RESPIRATORY CARBON DIOXIDE FROM (14)C DSMA-TREATED PLANTS, INDICATING C-AS BOND DEGRADATION. /METHANEARSONIC ACID, DISODIUM SALT/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：不太可能对人类致癌

Cancer Classification: Not Likely to be Carcinogenic to Humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

包含的化合物为甲酸和其钠盐；34例中有9例出现全身症状，其余有眼睛和皮肤刺激。

COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS; 9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

有机砷化合物包括甲基胂酸钠...和氨基甲基砷酸钠。这些化合物对人类的有毒性远低于...无机砷化合物；然而，如果吸入、吞咽或接触到眼睛或皮肤，它们仍然是有害的。/甲基胂酸钠/

ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE.TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALS; HOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN. /DISODIUM METHYLARSONATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

... 通过肾小管给牛每天每千克体重10毫克的甲基砷酸钠。在5只治疗中的牛中有4只，在治疗8-10天后死亡。死亡原因是明显的肾衰竭。在肾脏和肝脏中发现了高水平的砷。... 100和1000 PPM按重量比的... 甲基砷酸钠/在60%蔗糖浆中/对新生工蜂极其有毒 ... 纯净和商业配方的除草剂之间的毒性没有观察到差异。

... GAVE MONOSODIUM METHANEARSONATE TO CATTLE THROUGH RENAL TUBULES @ DOSE OF 10 MG/KG DAILY. FOUR OF 5 ... TREATED DIED AFTER 8-10 DAYS OF TREATMENT. CAUSE OF DEATH WAS APPARENT KIDNEY FAILURE. HIGH LEVELS OF ARSENIC WERE FOUND IN KIDNEY & LIVER. ... 100 & 1000 PPM BY WT OF ... MONOSODIUM METHANEARSONATE /IN 60% SUCROSE SYRUP/ WERE EXTREMELY TOXIC TO NEWLY EMERGED WORKER BEES ... NO DIFFERENCES IN TOXICITY WERE OBSERVED BETWEEN PURIFIED & COMMERCIALLY FORMULATED HERBICIDES.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

单钠砷酸甲酯和 cacodylic 酸对处理过的松树昆虫死亡率的影响进行了研究。观察到化合物之间的昆虫存活率差异。

... EXAMINED EFFECTS OF MONOSODIUM METHANEARSONATE & CACODYLIC ACID ON INSECT MORTALITY IN TREATED PONDEROSA PINES ... DIFFERENCES OF INSECT SURVIVAL BETWEEN CMPD WERE NOTED.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

MSMA比cacodylic acid（ cacodylic 酸）更快地转移到根系，并且可能转移到芽尖，但它并没有更大的植物毒性。当黑情人节豆类用(14)C MSMA处理时，在营养液上方、下方和营养液中发现了放射性MSMA。... 营养根茎积累砷，较小的根茎含有最高的浓度。

MSMA ... TRANSLOCATED MORE RAPIDLY THAN CACODYLIC ACID TO ROOT SYSTEM & PROBABLY ... SHOOT TIP, YET IT WAS NOT MORE PHYTOTOXIC. RADIOACTIVE MSMA WAS FOUND ABOVE, BELOW & IN NUTRIENT SOLN WHEN BLACK VALENTINE BEANS WERE TREATED WITH (14)C MSMA. ... NUTSEDGE TUBERS ACCUM ARSENIC & SMALLER TUBERS CONTAINED HIGHEST CONCN.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在棉花中...（14）C MSMA从子叶中转移的速度在20°C处理时比29°C处理时更快。最大吸收...发生在29°C。

/IN COTTON/ ... (14)C MSMA TRANSLOCATED OUT OF COTYLEDONS FASTER WHEN TREATED @ 20 °C THAN @ 29 °C. MAX ABSORPTION ... OCCURRED @ 29 °C.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 10毫克/千克/天 ... 在10天内对牛类证实致命；肾脏和肝脏中的砷含量在27-64 ppm范围内。

... 10 MG/KG/DAY ... PROVED FATAL TO CATTLE IN 10 DAYS; ARSENIC CONTENT OF KIDNEY & LIVER BEING IN RANGE 27-64 PPM.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当棉株高度达到7.6厘米并在初花期前施用甲烷亚砷酸及其钠盐和二钠盐时，棉籽中未发现显著的砷残留。

No significant arsenic residues are found in cottonseed when the sodium & disodium salts of methanearsonic acid are applied after the cotton has reached a height of 7.6 cm and before early bloom.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  Xn
• 安全说明：
  S20/21,S28,S45,S60,S61
• 危险类别码：
  R22
• 危险品运输编号：
  UN 1557
• 包装等级：
  III
• 危险类别：
  6.1(b)

制备方法与用途

用途：是制造田安的原材料，同时也是杀雄剂。

类别：农药

毒性分级：中毒

急性毒性：

• 大鼠口服 LD50: 821 毫克/公斤
• 小鼠口服 LD50: 1150 毫克/公斤

可燃性危险特性：受热分解产生有毒砷化物气体。

储运特性：

• 库房应通风、低温干燥
• 必须与食品原料分开储存和运输

灭火剂：砂土、干粉、泡沫

职业标准：时间加权平均容许浓度（TWA）0.5 毫克/立方米（砷）。