{2-[4-(4-chloro-benzyl)-2-phenyl-piperazin-1-yl]-ethyl}-diethyl-amine | 26841-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: {2-[4-(4-chloro-benzyl)-2-phenyl-piperazin-1-yl]-ethyl}-diethyl-amine
• 英文别名: 1-(4-chloro benzyl)-3-phenyl-4-(diethylamino ethyl) piperazine；1-(4'-Chloro benzyl)-3-phenyl-4-diethylamino ethyl piperazine；2-[4-[(4-chlorophenyl)methyl]-2-phenylpiperazin-1-yl]-N,N-diethylethanamine
• CAS: 26841-03-2
• 化学式: C₂₃H₃₂ClN₃
• 分子量: 385.98
• InChiKey: ZIUSQWKUOOKTMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-chloro-benzyl)-4-(2-diethylamino-ethyl)-3-phenyl-piperazin-2-one 生成 {2-[4-(4-chloro-benzyl)-2-phenyl-piperazin-1-yl]-ethyl}-diethyl-amine
  参考文献：
  名称：

  2-OR 3 KETO-3-OR-2-PHENYL-1,4-DISUBSTITUTED PIPERAZINES

  摘要：

  1,4-取代苯基哌嗪化合物对血液凝固具有显著影响，并且在治疗血栓性疾病，尤其是动脉系统的治疗中非常有用。它们特别用于抑制冠状动脉或脑动脉的血栓形成。这类化合物的示例包括1-苯基（较低）烷基-2-苯基-3-酮基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-酮基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-苯基-4-双烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪及其药学上可接受的酸盐。1-位置的苯环可能被卤素、三氟（较低）烷基、较低烷氧基或苯基较低烷氧基取代；4-位置的双（较低）烷氨基（较低）烷基基团可能被哌啶（较低）烷基、吗啉（较低）烷基、吡咯啉（较低）烷基、哌嗪（较低）烷基等单核氮杂环取代（较低）烷基所替代。

  公开号：

  US03935214A1

文献信息

• 2- OR 3-Phenyl 1,4-disubstituted phenyl piperazines
  申请人：Donau-Pharmazie Gesellschaft m.b.H.

  公开号：US04012389A1

  公开（公告）日：1977-03-15

  Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary or cerebral arteries. Examples of such compounds are 1-phenyl (lower) alkyl-2-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-3-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines and their pharmaceutically acceptable acid addition salts. The phenyl ring in 1-position may be substituted by halogen, trifluoro (lower)alkyl, lower alkoxy, or phenyl lower alkoxy; the di-(lower)alkylamino (lower)alkyl group in 4-position may be replaced by piperidino (lower)akyl, morpholino (lower)alkyl, pyrrolidino (lower)alkyl, piperazino (lower)alkyl, or the like mononuclear nitrogen-containing heterocyclically substituted (lower)alkyl.

  新型1,4-取代苯基哌嗪化合物对血液凝固有显著影响，可用于治疗血栓性疾病，特别是动脉系统的血栓。它们特别用于抑制冠状动脉或脑动脉的血栓形成。这类化合物的例子包括1-苯基（较低）烷基-2-苯基-4-二（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-3-苯基-4-二（较低）烷基氨基（较低）烷基哌嗪及其药学上可接受的酸加合物盐。1-位置的苯环可能被卤素，三氟（较低）烷基，较低烷氧基或苯基较低烷氧基取代；4-位置的二（较低）烷基氨基（较低）烷基基团可能被哌啶基（较低）烷基，吗啉基（较低）烷基，吡咯烷基（较低）烷基，哌嗪基（较低）烷基或类似的单核氮杂环取代（较低）烷基所取代。
• US3935214A
  申请人：——

  公开号：US3935214A

  公开（公告）日：1976-01-27
• US4012389A
  申请人：——

  公开号：US4012389A

  公开（公告）日：1977-03-15
• 2-OR 3 KETO-3-OR-2-PHENYL-1,4-DISUBSTITUTED PIPERAZINES
  申请人：Donau-Pharmazie Gesellschaft m.b.H.

  公开号：US03935214A1

  公开（公告）日：1976-01-27

  Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary or cerebral arteries. Examples of such compounds are 1-phenyl (lower) alkyl-2-phenyl-3-keto-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-2-keto-3-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower) alkyl-2-phenyl-4-di-alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-3-phenyl-4-di-(lower)-alkylamino (lower)alkyl piperazines and their pharmaceutically acceptable acid addition salts. The phenyl ring in 1-position may be substituted by halogen, trifluoro (lower)alkyl, lower alkoxy, or phenyl lower alkoxy; the di-(lower)alkylamino (lower)alkyl group in 4-position may be replaced by piperidino (lower)alkyl, morpholino (lower)alkyl, pyrrolidino (lower alkyl, piperazino (lower)alkyl, or the like mononuclear nitrogen-containing heterocyclically substituted (lower)alkyl.

  1,4-取代苯基哌嗪化合物对血液凝固具有显著影响，并且在治疗血栓性疾病，尤其是动脉系统的治疗中非常有用。它们特别用于抑制冠状动脉或脑动脉的血栓形成。这类化合物的示例包括1-苯基（较低）烷基-2-苯基-3-酮基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-酮基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-苯基-4-双烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪及其药学上可接受的酸盐。1-位置的苯环可能被卤素、三氟（较低）烷基、较低烷氧基或苯基较低烷氧基取代；4-位置的双（较低）烷氨基（较低）烷基基团可能被哌啶（较低）烷基、吗啉（较低）烷基、吡咯啉（较低）烷基、哌嗪（较低）烷基等单核氮杂环取代（较低）烷基所替代。