tert-butyl (2S)-2-(aminomethyl)azepane-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: tert-butyl (2S)-2-(aminomethyl)azepane-1-carboxylate
• 化学式: C₁₂H₂₄N₂O₂
• 分子量: 228.33
• InChiKey: JSPIOSPOMRTJBE-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：EP3548495A1

  公开（公告）日：2019-10-09
• [EN] PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLOPYRIMIDINE EN TANT QU'INHIBITEURS DE KINASE CAM
  申请人：GILEAD SCIENCES INC

  公开号：WO2018102384A1

  公开（公告）日：2018-06-07

  The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R9 and R10 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.