N-(1,2-benzisoxazol-3-ylmethyl)-N'-benzylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: N-(1,2-benzisoxazol-3-ylmethyl)-N'-benzylurea
• 英文别名: 1-(1,2-benzoxazol-3-ylmethyl)-3-benzylurea
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.31
• InChiKey: VINRJCDGFNXQQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS AND MATERIALS FOR INCREASING OR MAINTAINING NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE-2 (NMNAT2) POLYPEPTIDE LEVELS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20220169632A1

  公开（公告）日：2022-06-02

  This document provides methods and materials for increasing or maintaining NMNAT2 polypeptide levels within cells. For example, compounds (e.g., organic compounds) having the ability to increase or maintain NMNAT2 polypeptide levels within cells, formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for increasing or maintain NMNAT2 polypeptide levels within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in NMNAT2 polypeptide levels are provided (or for preventing said condition).