2-fluoromethyl-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one | 1419183-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 2-fluoromethyl-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 2-(fluoromethyl)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one
• CAS: 1419183-48-4
• 化学式: C₁₃H₉FN₂OS
• 分子量: 260.292
• InChiKey: LOQNULLVTLUNTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯甲基-5-苯基-3H-噻吩并[2,3-d]嘧啶-4-酮 在 苄基三乙基氯化铵 、 sodium fluoride 作用下， 以 二甲基亚砜 为溶剂， 以75%的产率得到2-fluoromethyl-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  Synthesis and antihyperlipidemic activity of novel condensed 2-fluoromethylpyrimidines

  摘要：

  A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague-Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals.A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue-Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.

  DOI：

  10.1007/s00044-012-0263-z

文献信息

• Synthesis and antihyperlipidemic activity of novel condensed 2-fluoromethylpyrimidines
  作者：Muthu K. Kathiravan、Kapil D. More、Vikas K. Raskar、Kishor S. Jain、Mukta Maheshwar、Sandeep Gadhwe、Dilpesh P. Jain、Madhuri A. Nagras、Manisha S. Phoujdar

  DOI：10.1007/s00044-012-0263-z

  日期：2013.9

  A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague-Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals.A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue-Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.