7-(4-fluorophenyl)-2-(pyridin-3-yl)-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine | 1070863-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 7-(4-fluorophenyl)-2-(pyridin-3-yl)-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine
• 英文别名: 7-(4-Fluorophenyl)-2-pyridin-3-yl-4,7-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine；7-(4-fluorophenyl)-2-pyridin-3-yl-4,7-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine
• CAS: 1070863-91-0
• 化学式: C₁₅H₁₂FN₇
• 分子量: 309.306
• InChiKey: PZUOIAAFQXDDHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  91.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl]guanidine 、 对氟苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 以91%的产率得到7-(4-fluorophenyl)-2-(pyridin-3-yl)-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine
  参考文献：
  名称：

  Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines

  摘要：

  In our lead finding program, 12 new fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines were prepared via a practical three-step procedure starting from (iso)nicotinic hydrazides. The fluorine substituted aryl fragment was introduced in the last step through cyclocondensation of N-(3-pyridyl-1,2,4-triazol-5-yl)guanidines and fluoro/trifluoromethyl substituted benzaldehydes. The structures of the compounds were confirmed by H-1 and C-13 NMR spectral data. The tautomeric preferences for the compounds were established using 2D NOESY experiments. The antiproliferative activity of the synthesized 1,2,4-triazolo[1,5-a][1,3,5]triazines was evaluated against breast, colon and lung cancer cell lines. The highest anti proliferative activity in the series was found for 2-(pyridine-3-yl)-7-(4-trifluoromethylphenyl)-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine. The lack of inhibitory activity against bovine dihydrofolate reductase (DHFR) indicated that the antiproliferative activity was realized via other mechanisms. (c) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2008.02.007

文献信息

• Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines
  作者：Anton V. Dolzhenko、Bee Jen Tan、Anna V. Dolzhenko、Gigi Ngar Chee Chiu、Wai Keung Chui

  DOI：10.1016/j.jfluchem.2008.02.007

  日期：2008.5

  In our lead finding program, 12 new fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines were prepared via a practical three-step procedure starting from (iso)nicotinic hydrazides. The fluorine substituted aryl fragment was introduced in the last step through cyclocondensation of N-(3-pyridyl-1,2,4-triazol-5-yl)guanidines and fluoro/trifluoromethyl substituted benzaldehydes. The structures of the compounds were confirmed by H-1 and C-13 NMR spectral data. The tautomeric preferences for the compounds were established using 2D NOESY experiments. The antiproliferative activity of the synthesized 1,2,4-triazolo[1,5-a][1,3,5]triazines was evaluated against breast, colon and lung cancer cell lines. The highest anti proliferative activity in the series was found for 2-(pyridine-3-yl)-7-(4-trifluoromethylphenyl)-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine. The lack of inhibitory activity against bovine dihydrofolate reductase (DHFR) indicated that the antiproliferative activity was realized via other mechanisms. (c) 2008 Elsevier B.V. All rights reserved.