三(2,4-二氯苯基)磷酸酯 | 3820-68-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 三(2,4-二氯苯基)磷酸酯
• 英文名称: tris(2,4-dichlorophenyl) phosphate
• 英文别名: phosphoric acid tris-(2,4-dichloro-phenyl ester)；Phosphorsaeure-tris-(2,4-dichlor-phenylester)；tri(2,4-dichlorophenyl) phosphate；2,4-dichlorophenyl phosphate
• CAS: 3820-68-6
• 化学式: C₁₈H₉Cl₆O₄P
• 分子量: 532.959
• InChiKey: FSDYDBAXNANUQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2919900090

反应信息

• 作为反应物：
  描述：

  三(2,4-二氯苯基)磷酸酯 在 硝酸 、 lanthanum(lll) triflate 作用下， 以 氯仿 为溶剂， 反应 7.0h， 以92.8%的产率得到phosphoric acid tris(2,4-dichloro-5-nitrophenyl) ester
  参考文献：
  名称：

  三(2,4-二氯-5-硝基)-磷酸酯的制备方法

  摘要：

  本发明公开了一种三（2,4‑二氯‑5‑硝基）‑磷酸酯的制备方法。在反应器中依次加入三（2,4‑二氯）‑磷酸酯、稀土三氟甲基磺酸盐催化剂和氯代烷烃溶剂，搅拌，滴加65%稀硝酸，控制温度在5～10℃；滴加结束后升温至10～20℃反应2h，然后逐渐升温到30～60℃，反应3h以上，反应结束后，降温到室温，分层，有机相通过蒸馏脱除溶剂后得到三（2,4‑二氯‑5‑硝基）‑磷酸酯。本发明在反应中采用以氯代烷烃为溶剂，三（2,4‑二氯）‑磷酸酯在稀土三氟甲基磺酸盐催化作用下，与稀硝酸反应，从根本上避免了传统硝化方法反应后产生的废混酸对环境的污染，同时硝化反应的选择性更为有效，使硝化产物三（2,4‑二氯‑5‑硝基）‑磷酸酯的收率从85%提高到90%以上，降低了生产成本，减轻了对环境的污染，对噁草酮的产业化发展起到了积极的作用。

  公开号：

  CN105693765B
• 作为产物：
  描述：

  2,4-二氯酚 在 magnesium chloride 、 三氯氧磷 作用下， 生成 三(2,4-二氯苯基)磷酸酯
  参考文献：
  名称：

  Kamai; Bogdanow, Metodiceskij sbornik, 1953, # 18, p. 22

  摘要：

  DOI：

文献信息

• Design of Experiments on the Transesterification of tris(p-nitrophenyl) Phosphate with Sodium Methoxide
  作者：Rafael C. Seiceira、Hatumi T. Nakayama、Claudio Costa Neto、João F. Cajaiba da Silva、Marcelo S. Pedrosa

  DOI：10.1080/104265090509171

  日期：2005.2

  reaction yielding bis(p-nitrophenyl) methyl phosphate. It was demonstrated that the temperature has a small effect on the reaction yield between 5 and 30ˆC. An important effect was observed with regard to the addition time of reagents and yield: when the tris(p-nitrophenyl)phosphate is added to the methoxide solution (58% on average) while no effect was observed when the methoxide solution was added to the

  摘要 通过实验设计研究磷酸三(对硝基苯基)酯与甲醇钠的酯交换反应。进行析因设计以检查有利于半间歇过程中双（对硝基苯基）甲基磷酸酯产率的实验条件。使用 Mettler RC1 量热仪进行实验。在两个不同的水平上分析反应温度、试剂的添加顺序和在这些添加中花费的时间。结果表明，试剂的添加顺序是保证双(对硝基苯基)甲基磷酸酯反应改善的最重要因素。结果表明，温度在 5~30℃范围内对反应产率的影响很小。在试剂的添加时间和收率方面观察到重要影响：当将三（对硝基苯基）磷酸酯加入甲醇溶液时（平均 58%），而当将甲醇溶液加入磷酸盐（平均 87%）时没有观察到影响。这些结果表明，在后一种条件下，可以在短于五分钟的时间内完成添加。
• Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
  申请人：——

  公开号：US20030170680A1

  公开（公告）日：2003-09-11

  Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.

  本发明揭示了一种新型寡聚物，与仅含传统碱基的寡聚物相比，具有增强的形成双链或三链的能力。该寡聚物包含5-（1-丙炔基）尿嘧啶，5-（1-丙炔基）胞嘧啶或相关类似物的碱基。本发明的寡聚物能够（i）通过在生理pH值下与靶DNA双链的主沟结合，形成与各种靶序列（如病毒或癌基因序列）的三链，或（ii）通过结合单链DNA或靶基因编码的RNA而形成双链。本发明的寡聚物可以被纳入药学可接受的载体中，并且可以构建任何所需的序列，只要序列通常包括一个或多个被本发明类似物替换的碱基。本发明的组合物可以用作制药剂治疗各种由病毒引起的疾病，并可用于诊断目的，以检测病毒或疾病情况。
• Pyrimidine derivatives for labeled binding partners
  申请人：——

  公开号：US20030176677A1

  公开（公告）日：2003-09-18

  Compounds having structure (1) 1 wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.

  具有结构（1）的化合物，其中R1是- H，保护基，连接剂或结合伙伴；而R2和R3是在规范中定义的。该发明还提供了制备结构（1）化合物的中间体和方法，以及将化合物用作诊断测定中的标记和增强与互补碱基的结合的方法。
• ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES
  申请人：——

  公开号：US20040265802A9

  公开（公告）日：2004-12-30

  Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.

  本发明披露了一种新型寡聚物，与仅含传统碱基的寡聚物相比，其具有增强的双链或三链形成能力。该寡聚物包含碱基5-(1-丙炔基)尿嘧啶，5-(1-丙炔基)胞嘧啶或相关类似物。本发明的寡聚物能够(i)在生理pH下通过耦合到目标DNA双链的主沟槽形成三链，如病毒或癌基因序列，或(ii)通过结合到单链DNA或由目标基因编码的RNA形成双链。本发明的寡聚物可以被纳入到药学可接受的载体中，并且可以构建任何所需的序列，只要该序列通常包括一个或多个被本发明的类似物替换的碱基。本发明的组合物可以用作制药剂治疗各种疾病，如由病毒引起的疾病，并且可以用于诊断目的，以检测病毒或疾病情况。
• Process for 2-(aminoalkylthio)carbapenems
  申请人：MERCK & CO. INC.

  公开号：EP0429726A1

  公开（公告）日：1991-06-05

  This invention relates to a process for preparing 2-(aminoalkylthio)carbapenems. In particular, this invention relates to a process in which a bis(substituted phenyl) phosphorohalidate is used to form an enol phosphate intermediate that can be converted to 2-(aminoalkylthio)carbapenems by reaction with suitable thioalkylamines.

  本发明涉及一种制备 2-(氨基烷硫基)碳青霉烯类化合物的工艺。特别是，本发明涉及一种工艺，在该工艺中，使用双（取代苯基）膦卤酸盐形成烯醇磷酸酯中间体，该中间体可通过与合适的硫代烷基胺反应转化为 2-(氨基烷硫基)碳青霉烯类。