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三(3,5-二甲苯基)磷酸酯 | 25653-16-1

中文名称
三(3,5-二甲苯基)磷酸酯
中文别名
磷酸三(3,5-二甲苯)酯(3:1)
英文名称
tris(3,5-dimethylphenyl) phosphate
英文别名
TDMPP;3,5-dimethyl-phenol, phosphate (3:1);phosphoric acid 3,5-xylyl ester;tris(3,5-xylyl) phosphate;Tris-<3,5-dimethyl-phenyl>-phosphat;Tris(3,5-xylenyl)phosphate
三(3,5-二甲苯基)磷酸酯化学式
CAS
25653-16-1
化学式
C24H27O4P
mdl
——
分子量
410.45
InChiKey
LLPMAOBOEQFPRE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    46 °C
  • 沸点:
    290 °C(Press: 10 Torr)
  • 密度:
    1.154±0.06 g/cm3(Predicted)
  • 溶解度:
    可溶于氯仿(少许)、甲醇(少许)
  • 颜色/状态:
    Wax

计算性质

  • 辛醇/水分配系数(LogP):
    7.2
  • 重原子数:
    29
  • 可旋转键数:
    6
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    44.8
  • 氢给体数:
    0
  • 氢受体数:
    4

ADMET

毒理性
  • 解毒与急救
基本治疗:建立专利气道。如有必要,进行吸痰。观察呼吸不足的迹象,如有需要,协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿,如有必要进行治疗……。监测休克,如有必要进行治疗……。预见并处理癫痫发作……。对于眼睛污染,立即用水冲洗眼睛。在运输过程中,用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入,如果患者能吞咽、有强烈的干呕反射且不流口水,则用水冲洗口腔,并给予5毫升/千克,最多200毫升的水进行稀释……。在去污后,用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 解毒与急救
高级治疗:对于无意识、严重肺水肿或呼吸停止的患者,考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。 ... 开始静脉输液,使用D5W/SRP:“保持开放”,最低流量/。如果出现低血容量的迹象,使用乳酸钠林格氏液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压,谨慎给予液体。注意液体过载的迹象。用地西泮(安定)治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/毒药A和B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 非人类毒性摘录
在给予口服三-(3,5-辛基)磷酸的公鸡中没有发现神经麻痹作用。当以1克/千克/天的剂量口服给药40天时,三-(3,5-辛基)磷酸显示出低毒性。
NO NEUROPARALYTIC EFFECTS WERE FOUND IN ROOSTERS GIVEN TRI-3,5-XYLENYL PHOSPHATE ORALLY. WHEN ADMIN AT 1 G/KG/DAY FOR 40 DAYS ORALLY TRI-3,5-XYLENYL PHOSPHATE SHOWED LOW TOXICITY.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 非人类毒性摘录
OMTI,一种基于三-3,5-联苯基磷酸的防火涡轮机气溶胶润滑剂,通过让小鼠、大鼠和豚鼠每天4小时吸入1-10毫克/立方米的剂量,持续16周,显示出对肺部、皮肤和周围神经的相对低毒性。
OMTI, A FIREPROOF AEROSOL LUBRICANT FOR TURBINES BASED ON TRI-3,5-XYLENYL PHOSPHATE, INHALED BY MICE, RATS, AND GUINEA PIGS AT 1-10 MG/CU M 4 HR DAILY FOR 16 WK SHOWED RELATIVELY LOW TOXICITY TO THE LUNG, SKIN, & PERIPHERAL NERVES.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • TSCA 测试提交
急性经口毒性在大鼠(数量、性别比例和品系未报告)中进行了评估,通过口服给予三(3,5-二甲苯基)磷酸(剂量水平、死亡率、临床观察和大体尸检未报告)。报告的急性经口LD50值大于4640毫克/千克。
Acute oral toxicity was evaluated in rats (number, sex ratio and strain not reported) administered tri-3,5-xylenyl phosphate orally (dose levels, mortalities, clinical observations and gross necropsy not reported). The acute oral LD50 was reported to be >4640 mg/kg.
来源:Hazardous Substances Data Bank (HSDB)

安全信息

  • 海关编码:
    2919900090

SDS

SDS:9cf6c316ff47dbc58d5904422a61b623
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上下游信息

反应信息

  • 作为反应物:
    描述:
    吲哚三(3,5-二甲苯基)磷酸酯 在 bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)] 、 N-[2-二(1-金刚烷)磷苯基]吗啉potassium carbonate 作用下, 以 neat (no solvent) 为溶剂, 反应 13.0h, 以92%的产率得到2,3-dihydro-1-(3,5-dimethylphenyl)-1H-indole
    参考文献:
    名称:
    钯催化的磷酸三芳基酯与C(sp 2)–N键的交叉偶联
    摘要:
    描述了芳基磷酸酯的第一常规钯催化的胺化。MorDalPhos与[Pd(π-肉桂基)Cl] 2的结合可实现富电子,电子中性和贫电子的芳基磷酸酯与一系列芳族,脂族和杂环胺的胺化反应。在此反应条件下,常见的官能团(如醚,酮,酯和腈)显示出极好的相容性。无溶剂胺化反应在两种固体偶联剂中也都成功。通过这种催化系统可以实现克级交叉偶联。
    DOI:
    10.1021/acs.joc.9b00703
  • 作为产物:
    描述:
    三(3,5-二甲基苯基)亚磷酸酯双氧水 作用下, 以 二甲基亚砜甲苯 为溶剂, 反应 0.5h, 以93%的产率得到三(3,5-二甲苯基)磷酸酯
    参考文献:
    名称:
    二苯二硒化物催化白磷合成亚磷酸三芳基酯和磷酸三芳基酯
    摘要:
    工业上重要的亚磷酸三芳基酯,传统上由 PCl 3制备,已通过涉及白磷和苯酚的二苯基二硒化物催化一步法合成,这为这些化合物提供了一种不含卤素和过渡金属的方法。随后亚磷酸三芳基酯氧化产生磷酸三芳基酯和硫代磷酸三芳基酯。三硫代磷酸酯也可以由芳香族硫醇和脂肪族硫醇有效地制备。
    DOI:
    10.1021/acs.orglett.1c01695
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文献信息

  • Polymer blends containing ionomeric rubbers and other ionomeric constituents
    申请人:GENERAL ELECTRIC COMPANY
    公开号:EP0136221A1
    公开(公告)日:1985-04-03
    @ Polymer blends having improved impact resistance and structural integrity comprise at least one aromatic polymer such as polyphenylene oxide, optionally in combination with a styrene homopolymer; at least one elastomer containing highly polar ionic (e.g. sulfonate or carboxylate) substituents, such as a sulfonated EPDM rubber; and at least one substituted aromatic polymer in which the substituents are highly polar ionic substituents, such as a sulfonated polyphenylene oxide or styrene-sodium acrylate copolymer. The compositions preferably also contain at least one plasticizer.
    具有更好抗冲击性和结构完整性的聚合物混合物包括至少一种芳香族聚合物,如聚苯醚,可选择与苯乙烯均聚物结合使用;至少一种含有高极性离子(如磺酸盐或羧酸盐)取代基的弹性体,如磺化三元乙丙橡胶;以及至少一种取代基为高极性离子取代基的取代芳香族聚合物,如磺化聚苯醚或苯乙烯-丙烯酸钠共聚物。 组合物最好还含有至少一种增塑剂。
  • Polyphenylene oxide blends containing ionomeric rubbers
    申请人:GENERAL ELECTRIC COMPANY
    公开号:EP0168652A2
    公开(公告)日:1986-01-22
    Polymer blends having improved impact resistance and structural integrity comprise at least one polyphenylene oxide, at least one elastomer containing highly polar ionic (e.g., sulfonate) substituents, such as a sulfonated EPDM rubber; and at least one plasticizer.
    具有更好抗冲击性和结构完整性的聚合物混合物包括至少一种聚苯醚、至少一种含有高极性离子(如磺酸盐)取代基(如磺化三元乙丙橡胶)的弹性体和至少一种增塑剂。
  • Lubricating oil additive, lubricating oil and working fluid for refrigerators
    申请人:JAPAN ENERGY CORPORATION
    公开号:EP0736591A2
    公开(公告)日:1996-10-09
    A lubricating oil additive composed of a partially etherified polyhydric alcohol which has at least two hydroxyl groups and bears at least one hydrocarbon group having at least one double bond in a state bonded through an ether linkage as an active component. The lubricating additive is added to a lube base oil to form a lubricating oil which can impart excellent wear resistance, which little corrodes metallic substances, which little swells rubbers or resins and which little forms sludge due to thermal oxidation. Therefore, the lubricating oil is mixed with a refrigerant to give a working fluid suitably usable for refrigerant compressors of domestic refrigerators, automotive air conditioners, refrigerators for industrial use and air conditioners.
    一种润滑油添加剂,由部分醚化的多元醇组成,这种多元醇具有至少两个羟基,并带有至少一个烃基,该烃基在通过醚键结合的状态下具有至少一个双键。将润滑添加剂添加到润滑油基础油中可形成一种润滑油,这种润滑油具有优异的耐磨性,对金属物质的腐蚀性小,对橡胶或树脂的膨胀性小,由于热氧化形成的油泥也小。因此,将润滑油与制冷剂混合,可得到一种工作液,适用于家用冰箱、汽车空调、工业用冰箱和空调的制冷剂压缩机。
  • Terephthalate stabilizers for fluoroolefins
    申请人:E. I. du Pont de Nemours and Company
    公开号:EP2420546A2
    公开(公告)日:2012-02-22
    The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one terephthalate or a mixture thereof with at least one of ascorbic acid and nitromethane. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.
    本公开涉及由至少一种氟烯烃和有效量的稳定剂组成的组合物,稳定剂由至少一种对苯二甲酸盐或其混合物与抗坏血酸和硝基甲烷中的至少一种组成。这种稳定组合物可用于制冷、空调、冷风机和热泵等冷却设备,也可用作发泡剂、溶剂、气溶胶推进剂、灭火剂和消毒剂。
  • Phosphorus-containing stabilizers for fluoroolefins
    申请人:E.I. Du Pont De Nemours And Company
    公开号:EP2410032A2
    公开(公告)日:2012-01-25
    The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one phosphorus-containing compound selected from the group consisting of thiophosphates, butylated triphenylphosphorothionates, and organophosphates. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.
    本公开涉及的组合物包含至少一种氟烯烃和有效量的稳定剂,稳定剂包含至少一种含磷化合物,该化合物选自由硫代磷酸盐、丁基化三苯基硫代磷酸盐和有机磷酸盐组成的组。这种稳定组合物可用于制冷、空调、冷却器和热泵等冷却设备,也可用作发泡剂、溶剂、气溶胶推进剂、灭火剂和消毒剂。
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