摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

三乙氧基-2-呋喃硅烷 | 75905-12-3

中文名称
三乙氧基-2-呋喃硅烷
中文别名
3-(三乙氧基甲硅烷基)呋喃
英文名称
3-(triethoxysilyl)furan
英文别名
triethoxy-3-furylsilane;3-(Triethoxysilyl)-furan;Triethoxy(furan-3-yl)silane
三乙氧基-2-呋喃硅烷化学式
CAS
75905-12-3
化学式
C10H18O4Si
mdl
MFCD05664290
分子量
230.336
InChiKey
FCIABWJRBPKYJO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    50 °C0.2 mm Hg(lit.)
  • 密度:
    1.004 g/mL at 25 °C(lit.)
  • 闪点:
    195 °F

计算性质

  • 辛醇/水分配系数(LogP):
    2.43
  • 重原子数:
    15
  • 可旋转键数:
    7
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.6
  • 拓扑面积:
    40.8
  • 氢给体数:
    0
  • 氢受体数:
    4

安全信息

  • WGK Germany:
    3
  • 海关编码:
    2932190090

SDS

SDS:5e2ab97d3fabc6049eed9ccea50b8cf6
查看

Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product name : 3-(Triethoxysilyl)furan

Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Not a dangerous substance according to GHS.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
This substance is not classified as dangerous according to Directive 67/548/EEC.
Other hazards - none

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Formula : C10H18O4Si
Molecular Weight : 230,33 g/mol
CAS-No. EC-No. Index-No. Classification Concentration
3-(Triethoxysilyl)furan
75905-12-3 - - - -

Section 4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water.
Consult a physician.

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires,
apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray;
solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Avoid breathing vapors, mist or gas. Remove all sources of ignition. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place
in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers
for disposal.

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic
charge.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
resealed and kept upright to prevent leakage. Store in cool place.
Moisture sensitive. Handle and store under inert gas.

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with
multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to
engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves
after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Eye protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
impervious clothing, The type of protective equipment must be selected according to the concentration
and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form liquid
Colour colourless
Safety data
pH no data available
Melting point no data available
Boiling point 50 °C at 0,3 hPa - lit.
Flash point 91 °C - closed cup
Ignition temperature no data available
Lower explosion limit no data available
Upper explosion limit no data available
Density 1,004 g/cm3 at 25 °C
Water solubility no data available

Section 10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
Avoid moisture.
Heat, flames and sparks.
Materials to avoid
Strong oxidizing agentsStrong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, silicon oxides

Section 11. TOXICOLOGICAL INFORMATION
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion
May be harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: Not available

Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available

Section 13. DISPOSAL CONSIDERATIONS
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and
scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

Section 14. TRANSPORT INFORMATION
ADR/RID
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods

Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.


SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

硅类亲核试剂适用于钯催化交叉偶联反应。

反应信息

  • 作为反应物:
    描述:
    三乙氧基-2-呋喃硅烷9-氯蒽 在 3-(dicyclohexylphosphino)-2-(2-methoxyphenyl)-1-methyl-1-H-indole 、 四丁基氟化铵 、 palladium diacetate 作用下, 以 甲苯 为溶剂, 反应 3.0h, 以75%的产率得到3-(anthracen-9-yl)furan
    参考文献:
    名称:
    普通钯催化的芳基和杂芳基氯化物的Hiyama交叉偶联反应
    摘要:
    提出了通过Pd(OAc)2 / L2催化体系对芳基和杂芳基氯化物与芳基和杂芳基三烷氧基硅烷进行钯催化的Hiyama交叉偶联反应。新开发的加水方案可以显着提高产品产量。Pd / L2的共轭该系统和加水方案可以在三小时内以优异的收率高效催化多种电子富集,中性,不足和空间受阻的芳基氯和杂芳基氯化物,而催化剂的负载量可低至0.05 mol%Pd第一次。还首次报道了杂芳基氯化物与杂芳基硅烷的Hiyama偶联。无需任何脱气和反应物纯化,即可轻松将反应放大至200倍(100 mmol)。这促进了常规合成中的实际应用。
    DOI:
    10.1002/chem.201600420
  • 作为产物:
    描述:
    3-furyllithium四氯化硅 以25%的产率得到
    参考文献:
    名称:
    LUKEVITS EH.; PUDOVA O. A.; ERCHAK N. P., ZH. OBSHCH. XIMII, 1980, 50 HO 6 1348-1353
    摘要:
    DOI:
点击查看最新优质反应信息

文献信息

  • 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
    申请人:PEYRONEL Jean-Francois
    公开号:US20100317675A1
    公开(公告)日:2010-12-16
    Compounds of formula (I): in which: X, R 1 , R 2 , R 3 and R 4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.
    式(I)的化合物:其中:X、R1、R2、R3和R4如本公开中所定义,或其酸盐;以及其治疗用途。
  • Catalytic Organocopper Chemistry from Organosiloxane Reagents
    作者:Jessica R. Herron、Vincenzo Russo、Edward J. Valente、Zachary T. Ball
    DOI:10.1002/chem.200901438
    日期:2009.9.7
    Organosilanes serve as precursors to organocopper intermediates in a copper‐catalyzed addition to vinylepoxides (see scheme). Ligand structure has a significant effect on the reactivity of the organocopper intermediate, and the catalysis proceeds without the need for a stoichiometric silane activator such as fluoride.
    有机硅烷在铜催化的乙烯基环氧化合物中作为有机铜中间体的前体(请参见方案)。配体结构对有机铜中间体的反应性具有显着影响,并且无需进行化学计量的硅烷活化剂(例如氟化物)即可进行催化。
  • 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof
    申请人:Sanofi
    公开号:US08314109B2
    公开(公告)日:2012-11-20
    Compounds of formula (I): in which: X, R1, R2, R3 and R4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.
    公式(I)的化合物: 其中,X,R1,R2,R3和R4如本文所定义,或其酸加成盐;以及它们的治疗用途。
  • 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
    申请人:PEYRONEL Jean-Francois
    公开号:US20130041152A1
    公开(公告)日:2013-02-14
    Compounds of formula (I): in which: X, R 1 , R 2 , R 3 and R 4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.
    化学式(I)的复合物:其中X、R1、R2、R3和R4如披露中所定义,或其酸加成盐;以及其治疗用途。
  • 6-heterocyclic imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof
    申请人:Peyronel Jean-Francois
    公开号:US08691990B2
    公开(公告)日:2014-04-08
    Compounds of formula (I): in which: X, R1, R2, R3 and R4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.
    式(I)的化合物:其中X、R1、R2、R3和R4如所述定义,或其酸加成盐;以及其治疗用途。
查看更多

同类化合物

(2-溴乙氧基)-特丁基二甲基硅烷 骨化醇杂质DCP 马来酸双(三甲硅烷)酯 顺式-二氯二(二甲基硒醚)铂(II) 顺-N-(1-(2-乙氧基乙基)-3-甲基-4-哌啶基)-N-苯基苯酰胺 降钙素杂质13 降冰片烯基乙基三甲氧基硅烷 降冰片烯基乙基-POSS 间-氨基苯基三甲氧基硅烷 镁,氯[[二甲基(1-甲基乙氧基)甲硅烷基]甲基]- 锑,二溴三丁基- 铷,[三(三甲基甲硅烷基)甲基]- 铂(0)-1,3-二乙烯-1,1,3,3-四甲基二硅氧烷 钾(4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-1-丁炔-1-基)(三氟)硼酸酯(1-) 金刚烷基乙基三氯硅烷 辛醛,8-[[(1,1-二甲基乙基)二甲基甲硅烷基]氧代]- 辛甲基-1,4-二氧杂-2,3,5,6-四硅杂环己烷 辛基铵甲烷砷酸盐 辛基衍生化硅胶(C8)ZORBAX?LP100/40C8 辛基硅三醇 辛基甲基二乙氧基硅烷 辛基三甲氧基硅烷 辛基三氯硅烷 辛基(三苯基)硅烷 辛乙基三硅氧烷 路易氏剂-3 路易氏剂-2 路易士剂 试剂3-[Tris(trimethylsiloxy)silyl]propylvinylcarbamate 试剂2-(Trimethylsilyl)cyclopent-2-en-1-one 试剂11-Azidoundecyltriethoxysilane 西甲硅油杂质14 衣康酸二(三甲基硅基)酯 苯胺,4-[2-(三乙氧基甲硅烷基)乙基]- 苯磺酸,羟基-,盐,单钠聚合甲醛,1,3,5-三嗪-2,4,6-三胺和脲 苯甲醇,a-[(三苯代甲硅烷基)甲基]- 苯基二甲基氯硅烷 苯基二甲基乙氧基硅 苯基乙酰氧基三甲基硅烷 苯基三辛基硅烷 苯基三甲氧基硅烷 苯基三乙氧基硅烷 苯基三丁酮肟基硅烷 苯基三(异丙烯氧基)硅烷 苯基三(2,2,2-三氟乙氧基)硅烷 苯基(3-氯丙基)二氯硅烷 苯基(1-哌啶基)甲硫酮 苯乙基三苯基硅烷 苯丙基乙基聚甲基硅氧烷 苯-1,3,5-三基三(三甲基硅烷)