三甲基氧鎓六氯锑酸 | 54075-76-2

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 三甲基氧鎓六氯锑酸
• 中文别名: 三甲基氧鎓六氯锑酸盐；六氯锑酸三甲基氧鎓
• 英文名称: Trimethyloxonium-hexachloroantimonat
• 英文别名: Antimony(5+);trimethyloxidanium;hexachloride
• CAS: 54075-76-2
• 化学式: C₃H₉O*Cl*Cl₅Sb
• 分子量: 395.572
• InChiKey: YAHNDGAYGJSBJE-UHFFFAOYSA-H

物化性质

• 物理描述：
  Trimethyloxonium hexachlorantimonate is a light brown powder. (NTP, 1992) It is a powerful alkylating agent.
• 溶解度：
  Unstable (NTP, 1992)
• 稳定性/保质期：

  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

锑在体内广泛分布。头发和皮肤含有最高的锑水平。肾上腺、肺、大肠、气管、小脑和肾脏也含有相对较高的锑。血液是将吸收的锑运输到体内各个组织隔室的主要载体。锑是一种金属，因此不会发生分解代谢。锑可以与巯基和磷酸共价相互作用，以及与内源性配体（例如，蛋白质）发生许多可逆的绑定相互作用。目前尚不清楚这些相互作用在毒理学上是否具有重要意义。锑通过尿液和粪便排出体外。部分粪便中的锑可能代表未被吸收的锑，这些锑通过粘液纤毛活动从肺部清除，进入食道再到胃肠道。

Antimony is widely distributed throughout the body. The hair and skin contain the highest levels of antimony. The adrenal glands, lung, large intestine, trachea, cerebellum, and kidneys also contain relatively high levels of antimony. Blood is the main vehicle for the transport of absorbed antimony to various tissue compartments of the body. Antimony is a metal and, therefore, does not undergo catabolism. Antimony can covalently interact with sulfhydryl groups and phosphate, as well as numerous reversible binding interactions with endogenous ligands (e.g., proteins). It is not known if these interactions are toxicologically significant. Antimony is excreted via the urine and feces. Some of the fecal antimony may represent unabsorbed antimony that is cleared from the lung via mucociliary action into the esophagus to the gastrointestinal tract. (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

吸入数据表明心肌是锑中毒的目标。锑可能通过干扰糖原分解和糖异生途径的酶来影响循环中的葡萄糖。锑的作用机制尚不清楚。然而，一些研究表明，锑与巯基团结合，包括一些对组织呼吸重要的酶中的巯基团。BAL的解毒作用取决于其阻止或打断锑与关键酶结合的能力。此外，死亡原因被认为是与急性砷中毒基本相同。(T18, L741, A238)

The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. (T18, L741, A238)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

无致癌性迹象（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity (not listed by IARC). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

皮肤接触锑可以导致锑斑（围绕汗腺和皮脂腺的丘疹和脓疱）。锑中毒还可能导致肺尘埃沉着病。吸入锑可能导致肺部功能改变和其他影响，包括慢性支气管炎、慢性肺气肿、活动性肺结核、胸膜粘连和刺激。锑中毒还可能导致血压升高。心肌抑制、血管扩张和体液流失可能导致低血压、电解质紊乱和急性肾衰竭的休克。脑水肿、昏迷、抽搐和死亡也是可能的。（L741）

Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入（L741）；口服（L741）；皮肤给药（L741）

Inhalation (L741) ; oral (L741) ; dermal (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

腹部疼痛、呕吐、腹泻可能是由吸入锑引起的。呼吸困难、头痛、呕吐、咳嗽、结膜炎和鼻出血脓性分泌物可能是由吸入暴露引起的。皮肤或眼睛接触可能会导致暴露表面疼痛和发红。（T64, L741）

Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (T64, L741)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  8
• 危险品标志：
  Xn,N
• 安全说明：
  S61
• 危险类别码：
  R20/22,R51/53
• 海关编码：
  2934999090
• 包装等级：
  III
• 危险品运输编号：
  UN 3261 8/PG 2

制备方法与用途

用途

酶甲基化试剂

反应信息

• 作为反应物：
  描述：

  N,N′-二叔丁基碳二亚胺 、 三甲基氧鎓六氯锑酸 以 二氯甲烷 为溶剂， 反应 24.0h， 以66%的产率得到1,3-Di-tert-butyl-1-methylcyanamidium-hexachloroantimonat
  参考文献：
  名称：

  Lambrecht, Johanna; Zsolnai, Laszlo; Huttner, Gottfried, Chemische Berichte, 1981, vol. 114, # 11, p. 3655 - 3666

  摘要：

  DOI：
• 作为产物：
  描述：

  环氧氯丙烷 生成 三甲基氧鎓六氯锑酸
  参考文献：
  名称：

  RIMMELIN, P.;TAGHAVI, HAMID;SOMMER, J., J. CHEM. SOC. CHEM. COMMUN., 1984, N 18, 1210-1211

  摘要：

  DOI：

文献信息

• 2-Alkyl-3-haloisothiazolium salts and their derivatives
  申请人：Givaudan Corporation

  公开号：US04508908A1

  公开（公告）日：1985-04-02

  This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.

  本公开涉及一种新型的2-烷基-3-卤异噻唑盐类。已发现这些盐类在控制细菌和真菌生长方面非常有用。它们还被发现是制备新型和已知抗菌和抗真菌化合物的有用中间体。
• 2-alkyl-3-haloisothiazol-3-thione
  申请人：Givaudan Corporation

  公开号：US04841063A1

  公开（公告）日：1989-06-20

  This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.

  本公开涉及一种新型的2-烷基-3-卤代异噻唑盐类。发现这些盐类对细菌和真菌的生长具有控制作用。同时，它们还被发现是制备新型和已知抗菌和抗真菌化合物的有用中间体。
• 3-Dicyanomethylene-4-isothiazolines
  申请人：Givaudan Corporation

  公开号：US04328347A1

  公开（公告）日：1982-05-04

  This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.

  本公开涉及一种新型的2-烷基-3-卤代异噻唑盐类。发现这些盐类对于控制细菌和真菌的生长非常有用。同时，它们也被发现是制备新型和已知的抗菌和抗真菌化合物的有用中间体。
• HARTKE K.; AKGUEN E., LIEBIGS ANN. CHEM., 1981, NO 1, 47-51
  作者：HARTKE K.、 AKGUEN E.

  DOI：——

  日期：——
• AKIBA, KIN-YA;TAKEE, KOHICHI;OHKATA, KATSUO;IWASAKI, FUJIKO, J. AMER. CHEM. SOC., 1983, 105, N 23, 6965-6966
  作者：AKIBA, KIN-YA、TAKEE, KOHICHI、OHKATA, KATSUO、IWASAKI, FUJIKO

  DOI：——

  日期：——

表征谱图