3-(hexadecyloxy)propyl phosphorodichloridate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 3-(hexadecyloxy)propyl phosphorodichloridate
• 英文别名: 3-(Hexadecyloxy)propyl phosphorodichloridate；1-(3-dichlorophosphoryloxypropoxy)hexadecane
• 化学式: C₁₉H₃₉Cl₂O₃P
• 分子量: 417.397
• InChiKey: BANDHHJFTXBGNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(hexadecyloxy)propyl phosphorodichloridate 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 生成 lithium salt of phosphoric acid [17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2-hexadecyloxy-ethylester
  参考文献：
  名称：

  Synthesis of Competitive Inhibitors of Phospholipase A 2 (PLA 2 )

  摘要：

  The synthetic routes for preparation of several phospholipid analogues such as lithium alkyl-3-alkoxy allylvinyl-sn-glycerol 5 and 6 and lithium trans-2-amidomethyl phosphate 7 and lithium cholesterol ester phosphate 8 containing ether, amide, and phosphate ester moieties are described.

  DOI：

  10.1080/10426500214877
• 作为产物：
  描述：

  十六烷基,1-3 丙二醇醚 在 TEA 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 生成 3-(hexadecyloxy)propyl phosphorodichloridate
  参考文献：
  名称：

  Synthesis of Competitive Inhibitors of Phospholipase A 2 (PLA 2 )

  摘要：

  The synthetic routes for preparation of several phospholipid analogues such as lithium alkyl-3-alkoxy allylvinyl-sn-glycerol 5 and 6 and lithium trans-2-amidomethyl phosphate 7 and lithium cholesterol ester phosphate 8 containing ether, amide, and phosphate ester moieties are described.

  DOI：

  10.1080/10426500214877

文献信息

• CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20210147456A1

  公开（公告）日：2021-05-20

  An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R 1 represents a halogen atom, an amino group which may be substituted, a C 1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R 2 represents a hydrogen atom or an amino protecting group; R 3 represents a C 1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R 4 represents a C 1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

  本发明的一个目的是提供一种作为抗腺病毒药剂的化合物，以及一种抗腺病毒药剂。本发明提供一种由通式[1]表示的化合物 （在该式中，R 1 代表卤原子，可能被取代的氨基，可能被取代的C 1-6 烷氧基，可能被保护的羟基等；R 2 代表氢原子或氨基保护基；R 3 代表可能被取代的C 1-20 烷氧基，可能被取代的芳氧基，可能被取代的氨基等；R 4 代表可能被取代的C 1-20 烷氧基，可能被取代的芳氧基，可能被取代的氨基等）；或其盐。
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION<br/>[FR] COMPOSÉS, COMPOSITIONS, ET PROCÉDÉS POUR LE TRAITEMENT D'UNE INFECTION VIRALE
  申请人：CHIMERIX INC

  公开号：WO2010135520A1

  公开（公告）日：2010-11-25

  The present invention describes compounds of formulae I and II and methods for treating viral infection, such as Flaviviridae virus infection, including Hepatitis C infection (HCV).

  本发明描述了式I和式II的化合物以及治疗病毒感染的方法，例如黄病毒科病毒感染，包括丙型肝炎病毒感染（HCV）。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION
  申请人：Almond Merrick

  公开号：US20100297079A1

  公开（公告）日：2010-11-25

  The present invention describes compounds of formulae I and II and methods for treating viral infection, such as Flaviviridae virus infection, including Hepatitis C infection (HCV).

  本发明描述了I和II式化合物以及治疗病毒感染的方法，例如Flaviviridae病毒感染，包括丙型肝炎（HCV）感染。
• Synthesis of Competitive Inhibitors of Phospholipase A 2 (PLA 2 )
  作者：Nosrat O. Mahmoodi

  DOI：10.1080/10426500214877

  日期：2002.12.1

  The synthetic routes for preparation of several phospholipid analogues such as lithium alkyl-3-alkoxy allylvinyl-sn-glycerol 5 and 6 and lithium trans-2-amidomethyl phosphate 7 and lithium cholesterol ester phosphate 8 containing ether, amide, and phosphate ester moieties are described.