{G1}-(SiMe2Cl)8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: {G1}-(SiMe2Cl)8
• 英文别名: Tetrakis[3-[bis[3-[chloro(dimethyl)silyl]propyl]-methylsilyl]propyl]silane；tetrakis[3-[bis[3-[chloro(dimethyl)silyl]propyl]-methylsilyl]propyl]silane
• 化学式: C₅₆H₁₃₂Cl₈Si₁₃
• 分子量: 1454.4
• InChiKey: SBZOSISMCDMONC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  27.98
• 重原子数：
  77
• 可旋转键数：
  48
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  {G1}-(SiMe2Cl)8 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 Tetrakis[3-[bis(3-dimethylsilylpropyl)-methylsilyl]propyl]silane
  参考文献：
  名称：

  Structural Defects in Polyallylcarbosilane Dendrimers and Their Polyol Derivatives Characterized by NMR and MALDI-TOF Mass Spectrometry

  摘要：

  A series of polyallylcarbosilane dendrimers and carbosilane-based dendritic polyols up to third generation was analyzed by means of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry and multinuclear NMR spectroscopy to determine the character, origin, and number of structural defects. Besides occasionally reported alpha-hydrosilylation, several side reactions accompanying hydrosilylation, such as isomerization of terminal double bonds, were detected during the synthesis of carbosilane skeleton. Despite increased steric hindrance, internal double bonds react in subsequent addition reactions. Depending on the synthetic sequence applied, the retained reactivity of the internal double bonds can lead either to suppression of the defect in the next generation or to creation of more significant defects such as dendrimer dimers. Hydroboration of allyl groups using dicyclohexylborane proceeded with near quantitative conversion: a small amount of hydrolysis accompanying the following oxidation step producing nonreactive alkyl groups at the periphery was detected.

  DOI：

  10.1021/ma100315w
• 作为产物：
  描述：

  二甲基一氯硅烷 、 3-[Allyl-methyl-(3-{tris-[3-(diallyl-methyl-silanyl)-propyl]-silanyl}-propyl)-silanyl]-propene 在 铂(0)-1,3-二乙烯-1,1,3,3-四甲基二硅氧烷 作用下， 生成 {G1}-(SiMe2Cl)8
  参考文献：
  名称：

  Structural Defects in Polyallylcarbosilane Dendrimers and Their Polyol Derivatives Characterized by NMR and MALDI-TOF Mass Spectrometry

  摘要：

  A series of polyallylcarbosilane dendrimers and carbosilane-based dendritic polyols up to third generation was analyzed by means of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry and multinuclear NMR spectroscopy to determine the character, origin, and number of structural defects. Besides occasionally reported alpha-hydrosilylation, several side reactions accompanying hydrosilylation, such as isomerization of terminal double bonds, were detected during the synthesis of carbosilane skeleton. Despite increased steric hindrance, internal double bonds react in subsequent addition reactions. Depending on the synthetic sequence applied, the retained reactivity of the internal double bonds can lead either to suppression of the defect in the next generation or to creation of more significant defects such as dendrimer dimers. Hydroboration of allyl groups using dicyclohexylborane proceeded with near quantitative conversion: a small amount of hydrolysis accompanying the following oxidation step producing nonreactive alkyl groups at the periphery was detected.

  DOI：

  10.1021/ma100315w

文献信息

• Water-Soluble Carbosilane Dendrimers: Synthesis Biocompatibility and Complexation with Oligonucleotides; Evaluation for Medical Applications
  作者：Jesus F. Bermejo、Paula Ortega、Louis Chonco、Ramon Eritja、Rafael Samaniego、Matthias Müllner、Ernesto de Jesus、F. Javier de la Mata、Juan Carlos Flores、Rafael Gomez、Angeles Muñoz-Fernandez

  DOI：10.1002/chem.200600594

  日期：2007.1.2

  Si--H bonds of the dendritic systems and subsequent quaternization with HCl. Quaternized carbosilane dendrimers are soluble in water, although degradation is apparent due to hydrolysis of Si--O bonds. However, dendrimers containing Si--C bonds are water-stable. The biocompatibility of the second-generation dendrimers in primary cell cultures of peripheral blood mononuclear cells (PBMCs) and erythrocytes

  nG- [Si O （C6H3）-3,5-（O NMe2）2}] x，nG- [Si O（CH2）2N（Me）（ ）2NMe2类型的新型胺或铵封端的碳硅烷树状大分子}] x和nG- [Si （ ）3NH2}] x或nG- [Si O （ ）-3,5-（O NMe3 + I-）2}] x，nG- [Si O CH（ ）2N（Me）（ ）2NMe3 + I-}] x和nG- [Si （ ）3NH3 + Cl-}] x已合成并表征到第三代，通过两种策略进行：1）醇解Si-Cl与氨基醇键合，随后与MeI季铵化，以及2）烯丙基胺与树状体系的Si-H键的硅氢加成氢化反应，随后与HCl季铵化。季铵化碳硅烷树状聚合物可溶于水，尽管由于Si-O键的水解而导致降解明显。然而，含有Si-C键的树枝状聚合物是水稳定的。已经分析了第二代树状聚合物
• “Catalysis in a Tea Bag”: Synthesis, Catalytic Performance and Recycling of Dendrimer-Immobilised Bis- and Trisoxazoline Copper Catalysts
  作者：Manuela Gaab、Stéphane Bellemin-Laponnaz、Lutz H. Gade

  DOI：10.1002/chem.200900504

  日期：2009.5.25

  Trapped in a “tea bag”: Membrane bags, fabricated from a dialysis membrane, have been employed as semipermeable containers for dendrimer‐immobilised oxazoline–copper(II) Lewis acid catalysts. Dipping them into reactant solutions leads to the catalytic conversion of the substrates, which penetrate the membrane as does the product in the reverse direction (see scheme).

  装在“茶袋”中：用透析膜制成的膜袋已被用作固定树枝状聚合物的恶唑啉-铜（II）Lewis酸催化剂的半渗透性容器。将它们浸入反应物溶液中会导致底物的催化转化，而底物的催化转化方式与产品的反方向一样（参见方案）。
• Novel Water‐Soluble Carbosilane Dendrimers: Synthesis and Biocompatibility
  作者：Paula Ortega、Jesus F. Bermejo、Louis Chonco、Ernesto de Jesus、F. Javier de la Mata、Gerónimo Fernández、Juan Carlos Flores、Rafael Gómez、M. Jesús Serramía、M. Angeles Muñoz‐Fernandez

  DOI：10.1002/ejic.200500782

  日期：2006.4

  ammonium-terminated carbosilane dendrimers of type nG-[Si(OCH2CH2NMe2)y]x or nG-[Si(OCH2CH2NMe3+I–)y]x, respectively. It consists of the alcoholysis of well-known chlorosilane-terminated dendrimers with N,N-dimethylethanolamine and the subsequent quaternization with MeI. All these systems are susceptible to hydrolysis, although the decomposition depends on concentration and dendrimer generation. Evaluation

  已经开发了一种合成策略，用于制备分别为 nG-[Si(OCH2CH2NMe2)y]x 或 nG-[Si(OCH2CH2NMe3+I-)y]x 型的新型外围胺或铵封端碳硅烷树枝状聚合物。它由众所周知的氯硅烷封端的树枝状聚合物与 N,N-二甲基乙醇胺的醇解和随后与 MeI 的季铵化组成。尽管分解取决于浓度和树枝状聚合物的生成，但所有这些系统都易于水解。通过相差光学显微镜和 MTT 测定评估树枝状聚合物的毒性，并通过凝胶电泳进行树枝状聚合物/寡核苷酸复合物形成的证据。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• Generation effects on the microstructure and product distribution in ethylene polymerization promoted by dendritic nickel catalysts
  作者：José M. Benito、Ernesto de Jesús、F. Javier de la Mata、Juan C. Flores、Rafael Gómez

  DOI：10.1039/b511379m

  日期：——

  Carbosilane dendrimers Gn-[(ONNMe2)NiBr2]m, containing up to sixteen terminal pyridylimine nickel complexes, have been studied as catalysts for polymerization of ethylene; the microstructure and the oligomer/polymer distribution are significantly affected by the generation of the dendritic precursor.

  碳硅烷树枝状聚合物Gn-[（ONNMe2）NiBr2] m含有多达十六个吡啶基嘧啶镍配合物，已被研究用作乙烯聚合的催化剂。树枝状前体的产生显着影响了微观结构和低聚物/聚合物的分布。
• Arylimido niobium(V) complexes: mononuclear and dendritic derivatives
  作者：José M Benito、Ernesto de Jesús、F Javier de la Mata、Juan C Flores、Rafael Gómez、Pilar Gómez-Sal

  DOI：10.1016/s0022-328x(02)02019-3

  日期：2002.12

  SiMe3)2)2)2)4 (8). The N,N-bis(trimethylsilyl)aniline groups of 3 reacted with niobium pentachloride in acetonitrile or [NbCp′Cl4] (Cp′=η5-C5H4SiMe3) in dichloromethane to give imido mononuclear complexes [Nb(NC6H4SiMe3-4)Cl3(CH3CN)2] (4) and [NbCp′(NC6H4SiMe3-4)Cl2] (5), respectively. Reaction of dendrimers 6–8 and [NbCp′Cl4] in CH2Cl2 afforded metallodendrimers [Si(CH2CH2CH2SiMe2C6H4NNbCp′Cl2)4]

  化合物4-LiC 6 H 4 N（SiMe 3）2在四氢呋喃中与SiMe 3 Cl或与第一代，第二代和第三代碳硅烷树状大分子外围的氯化硅基反应，得到4-SiMe 3 C 6 H 4 N（SiMe 3）2（3）和官能化的树枝状聚合物Si（CH 2 CH 2 CH 2 SiMe 2 C 6 H 4 N（SiMe 3）2）4（6），Si（CH2 CH 2 CH 2 SiMe（CH 2 CH 2 CH 2 SiMe 2 C 6 H 4 N（SiMe 3）2）2）4（7）和Si（CH 2 CH 2 CH 2 SiMe（CH 2 CH 2 CH 2 SiMe（CH 2 CH 2 CH 2 SiMe 2 C 6 H 4 N（SiMe 3）2）2）2）4（8）。的Ñ，ñ -双的（三甲基甲硅烷）苯胺基3与五氯化铌在乙腈或[NbCP'Cl反应4 ]（CP'=η 5 -C 5 H ^ 4森达3）在二氯甲烷，得到酰亚胺单核配合物[铌（