trisodium silver (I) thiosulfate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 英文名称: trisodium silver (I) thiosulfate
• 英文别名: silver thiosulfate ion complex
• 化学式: AgNaO3S2
• 分子量: 242.99
• InChiKey: KALHNGQSDVPNRB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.0
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trisodium silver (I) thiosulfate 、 silver nitrate 以 氨 为溶剂， 生成 sodium silver thiosulfate * water
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ag: MVol.B3, 11.6.6.2.4, page 118 - 119

  摘要：

  DOI：
• 作为产物：
  描述：

  Sodium thiosulfate pentahydrate 、 silver thiocyanate 以 氨 为溶剂， 生成 trisodium silver (I) thiosulfate
  参考文献：
  名称：

  Garkusha, G. A., 1953, vol. 2, p. 1666 - 1673

  摘要：

  DOI：

文献信息

• Stabilized silver-ion sulfite complex compositions and methods
  申请人：BioInterface Technologies, Inc.

  公开号：US20040214809A1

  公开（公告）日：2004-10-28

  The present invention relates to novel stabilized silver ion complexes having improved stability in aqueous solutions. The described stabilized silver-ion complex compositions comprise a silver-thiosulfate ion complex, a sulfite stabilizing agent either with or without a sulfite preservation agent. These carrier-free aqueous sulfite stabilized silver thiosulfate ion complex compositions have improved stability when exposed to an aqueous environment for extended periods. Consequently, these compositions have improved antibacterial, anti-viral and/or antifungal activity. These stabilized compositions can be used to coat a wound dressing, an ostomy appliance, an incontinence device, or other medical devices and impart long-term antimicrobial activity.

  本发明涉及一种新型的在水溶液中具有改善稳定性的稳定化银离子络合物。所述的稳定化银离子络合物组合物包括一种银硫代硫酸盐离子络合物，一种亚硫酸盐稳定剂，可以是带有或不带有亚硫酸盐防腐剂。这些无载体的水溶性亚硫酸盐稳定化银硫代硫酸盐离子络合物组合物在暴露于水环境中较长时间后具有改善的稳定性。因此，这些组合物具有改善的抗菌、抗病毒和/或抗真菌活性。这些稳定化组合物可用于包覆伤口敷料、造口器具、失禁器具或其他医疗器械，并赋予长期的抗菌活性。
• The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death
  作者：Akira Ota、Masataka Tajima、Kazunori Mori、Erika Sugiyama、Vilasinee Hirunpanich Sato、Hitoshi Sato

  DOI：10.1007/s43440-021-00260-0

  日期：2021.6

  Silver is a transition metal that is known to be less toxic than platinum. However, only few studies have reported the anticancer effects of some silver complexes and their possibility as an alternative to platinum complex. This study investigated the anticancer effects of the silver thiosulfate complex (STS), [Ag(S₂O₃)₂]³⁻, consisting of silver and sodium thiosulfate.

  In vitro cytotoxic activity of STS was investigated comparatively in human cancer cell lines (K562 and MCF-7) and normal human cells (mesenchymal stem cells and mammary epithelial cells). For its anticancer effects, cell cycle, mode of cell death, morphological changes, and accumulation of intracellular ROS and GSH were evaluated in MCF-7 to provide mechanistic insights.

  STS showed a concentration-dependent cytotoxicity in MCF-7 cell, which was abolished by pretreatment with N-acetylcysteine, suggesting ROS accumulation by STS. Moreover, STS caused cell cycle arrest at the G1 phase, decrease in the GSH levels, and morphological changes in MCF-7. Direct measurement of ROS demonstrated the elevation of intracellular ROS accumulation in cancer cells treated with STS; however, neither cytotoxicity nor ROS accumulation was observed in normal human cells.

  The results obtained here are the first evidence to show that STS exhibited an anticancer activity through ROS-induced mechanisms, and that its cytotoxicity is highly selective to cancer cells. The results of the present study warrant further investigation on the detailed mechanism of STS actions, as well as its in vivo effectiveness and safety for clinical application.

  摘要 背景 银是一种过渡金属，据称比铂更少毒性。然而，只有少数研究报告了一些银配合物的抗癌效果以及它们作为铂配合物替代品的可能性。本研究调查了硫代硫酸银配合物（STS）的抗癌效果，[Ag(S₂O₃)₂]³⁻，由银和硫代硫酸钠组成。 方法 对STS在人类癌细胞系（K562和MCF-7）和正常人细胞（间充质干细胞和乳腺上皮细胞）中的体外细胞毒活性进行了比较研究。为了了解其抗癌效果，评估了MCF-7中的细胞周期、细胞死亡方式、形态学变化以及细胞内ROS和GSH的积累，以提供机制洞察。 结果 STS在MCF-7细胞中显示出浓度依赖性的细胞毒性，经N-乙酰半胱氨酸预处理后被消除，表明STS引起ROS积累。此外，STS导致MCF-7中G1期细胞周期停滞，GSH水平下降，形态学变化。ROS的直接测量表明，用STS处理的癌细胞中细胞内ROS积累增加；然而，在正常人细胞中既未观察到细胞毒性也未观察到ROS积累。 结论 本研究结果首次证明了STS通过ROS诱导机制表现出抗癌活性，并且其细胞毒性对癌细胞高度选择性。本研究的结果需要进一步研究STS作用的详细机制，以及其在体内的有效性和临床应用的安全性。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: S: MVol.B2, 7.6.1, page 936 - 952
  作者：

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: S: MVol.B2, 7.3.2, page 874 - 876
  作者：

  DOI：——

  日期：——
• Gascon, J., Revista de la Facultad de Ciencias Quimicas, Universidad Nacional de La Plata, 1928, vol. 5, p. 41 - 72
  作者：Gascon, J.

  DOI：——

  日期：——