2-(pyridin-2-yl)phenyl benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 2-(pyridin-2-yl)phenyl benzoate
• 英文别名: (2-Pyridin-2-ylphenyl) benzoate；(2-pyridin-2-ylphenyl) benzoate
• 化学式: C₁₈H₁₃NO₂
• 分子量: 275.307
• InChiKey: YBWYAIOHWCZIKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  碘苯二乙酸 在 palladium diacetate 作用下， 以 甲醇 、 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 8.5h， 生成 2-(pyridin-2-yl)phenyl benzoate
  参考文献：
  名称：

  Palladium catalyzed ortho-C–H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates

  摘要：

  A palladium-catalyzed ortho-C-H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates has been developed. The reaction employed the stable and easily accessible hypervalent iodine reagents as both benzoxylate source and oxidant which made the protocol simple and facile. It showed high regioselectivity and good functional group tolerance, and gave the mono-benzoxylation products in moderate to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.09.097

文献信息

• Ceric Ammonium Nitrate (CAN) Promoted Pd^II-Catalyzed Substrate-Directed<i>o</i>-Benzoxylation and Decarboxylative<i>o</i>-Aroylation
  作者：Sourav Kumar Santra、Arghya Banerjee、Nilufa Khatun、Bhisma K. Patel

  DOI：10.1002/ejoc.201403367

  日期：2015.1

  Inexpensive ceric ammonium nitrate (CAN) is an efficient oxidant for the Pd-catalyzed substrate-directed o-benzoxylation and decarboxylative o-aroylation processes. In the presence of CAN, the reaction of directing arenes with carboxylic acids resulted in o-benzoxylated products, whereas a decarboxylative o-aroylation occurred by using α-keto acids, which led to the formation of o-aroylation products

  廉价的硝酸铈铵 (CAN) 是 Pd 催化的底物导向邻苯甲氧基化和脱羧邻芳酰化过程的有效氧化剂。在 CAN 存在下，定向芳烃与羧酸反应生成邻苯甲酰化产物，而使用 α-酮酸发生脱羧邻芳酰化，从而形成邻芳酰化产物。
• Copper-catalyzed C–H acyloxylation of 2-phenylpyridine using oxygen as the oxidant
  作者：Feifan Wang、Zhiyang Lin、Weisheng Yu、Qingdong Hu、Chao Shu、Wu Zhang

  DOI：10.1039/c8ra01974f

  日期：——

  o-acyloxylation of 2-phenylpyridine with carboxylic acids using oxygen as the oxidant has been developed. Various acids including aromatic acids, cinnamic acids and aliphatic acids are effective acyloxylation reagents and provide the desired products in moderate to excellent yields. The reaction proceeds well under an oxygen atmosphere, making this method potentially practical.

  已经开发了一种使用氧作为氧化剂的有效的铜催化的 2-苯基吡啶与羧酸的直接邻酰氧基化反应。包括芳香酸、肉桂酸和脂肪酸在内的各种酸是有效的酰氧基化试剂，并以中等至极好的收率提供所需的产品。该反应在氧气气氛下进行得很好，使该方法具有潜在的实用性。
• Copper catalyzed oxidative ortho-C–H benzoxylation of 2-phenylpyridines with benzyl alcohols and benzyl amines as benzoxylation sources
  作者：Ashok B. Khemnar、Bhalchandra M. Bhanage

  DOI：10.1039/c4ob01912a

  日期：——

  An efficient methodology for the ortho benzoxylation of 2-phenylpyridine via C–H bond activation using benzyl alcohols and benzyl amines as arylcarboxy sources has been developed.

  一种高效的方法论已经开发出来，用于通过苄醇和苄胺作为芳基羧源进行C-H键活化的2-苯基吡啶的正苄基化。
• Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides
  作者：Wing-Nga Sit、Chun-Wo Chan、Wing-Yiu Yu

  DOI：10.3390/molecules18044403

  日期：——

  A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield.

  开发了一种钯(II)催化的2-芳基吡啶与芳基过氧化酮的邻位苯氧基化反应。以吡啶基作为指导基团，该苯氧基化反应表现出显著的区域选择性和优异的功能团耐受性，产物的收率高达87%。
• Bimetallic Reductive Elimination from Dinuclear Pd(III) Complexes
  作者：David C. Powers、Diego Benitez、Ekaterina Tkatchouk、William A. Goddard、Tobias Ritter

  DOI：10.1021/ja1036644

  日期：2010.10.13

  C-halogen reductive elimination reactions from dinuclear Pd(III) complexes and implicated dinuclear intermediates in Pd(OAc)(2)-catalyzed C-H oxidation chemistry. Herein, we report results of a thorough experimental and theoretical investigation of the mechanism of reductive elimination from such dinuclear Pd(III) complexes, which establish the role of each metal during reductive elimination. Our results

  2009 年，我们报道了双核 Pd(III) 配合物和 Pd(OAc)(2) 催化 CH 氧化化学中涉及的双核中间体的 C-卤素还原消除反应。在此，我们报告了对这种双核 Pd(III) 配合物的还原消除机制的彻底实验和理论研究的结果，这确定了每种金属在还原消除过程中的作用。我们的结果暗示了双核完整的复合物的还原消除，并表明两种金属之间的氧化还原协同作用是观察到的简单还原消除反应的原因。