adenosine(adenine arabinofuranoside) 5',5'''-P¹,P⁴-tetraphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: adenosine(adenine arabinofuranoside) 5',5'''-P¹,P⁴-tetraphosphate
• 英文别名: Ap4(arabino-A)；[[(2R,3S,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
• 化学式: C₂₀H₂₈N₁₀O₁₉P₄
• 分子量: 836.393
• InChiKey: YOAHKNVSNCMZGQ-LEPIKIPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.3
• 重原子数：
  53
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  434
• 氢给体数：
  10
• 氢受体数：
  27

反应信息

• 作为产物：
  描述：

  5’-三磷酸腺苷 在 TRIS buffer pH 8 、 potassium chloride 、 magnesium chloride 、 zinc(II) chloride 作用下， 反应 2.5h， 生成 adenosine(adenine arabinofuranoside) 5',5'''-P¹,P⁴-tetraphosphate
  参考文献：
  名称：

  Characterisation of stress protein LysU. Enzymic synthesis of diadenosine 5′,5‴-P¹,P⁴-tetraphosphate (Ap₄A) analogues by LysU

  摘要：

  The stress protein LysU (lysyl tRNA synthetase) has been purified from a recombinant strain of Escherichia coli expressing the plasmid pXLys5, and kinetically characterised. Preparative syntheses of analogues of the biologically important molecule diadenosine 5',5'''-P-1,P-4-tetraphosphate (Ap(4)A) are then achieved in good yield by enzyme catalysis, using purified LysU.

  DOI：

  10.1039/p19960002009

文献信息

• Enzymatic synthesis of diadenosine 5′, 5‴-P¹, P⁴-tetraphosphate (Ap₄A) analogues by stress protein LysU
  作者：Maria-Elena Theoclitou、Talal S. H. El-Thaher、Andrew D. Miller

  DOI：10.1039/c39940000659

  日期：——

  Preparative synthesis of analogues of the biologically important molecule diadenosine 5′, 5‴-P1, P4-tetraphosphate (Ap4A) is achieved in good yield by enzyme catalysis using the stress protein LysU.

  通过使用应激蛋白 LysU 进行酶催化，制备合成了具有重要生物学意义的分子二腺苷 5â²，5â´-P1，P4-tetraphosphate（Ap4A）的类似物，而且产量很高。
• Characterisation of stress protein LysU. Enzymic synthesis of diadenosine 5′,5‴-P¹,P⁴-tetraphosphate (Ap₄A) analogues by LysU
  作者：Maria-Elena Theoclitou、E. Pernilla L. Wittung、Alison D. Hindley、Talal S. H. El-Thaher、Andrew D. Miller

  DOI：10.1039/p19960002009

  日期：——

  The stress protein LysU (lysyl tRNA synthetase) has been purified from a recombinant strain of Escherichia coli expressing the plasmid pXLys5, and kinetically characterised. Preparative syntheses of analogues of the biologically important molecule diadenosine 5',5'''-P-1,P-4-tetraphosphate (Ap(4)A) are then achieved in good yield by enzyme catalysis, using purified LysU.