乙烯基乙基甲基氯硅烷 | 18293-66-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 乙烯基乙基甲基氯硅烷
• 英文名称: Chlor-methyl-ethyl-vinyl-silan
• 英文别名: Ethyl-chlor-methyl-vinyl-silan；chloroethenylethylmethyl-silane；Chloro-ethenyl-ethyl-methylsilane
• CAS: 18293-66-8
• 化学式: C₅H₁₁ClSi
• 分子量: 134.681
• InChiKey: YCMWEGOONYILCI-UHFFFAOYSA-N

物化性质

• 沸点：
  117 °C(Press: 750 Torr)
• 密度：
  0.8923 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  乙烯基乙基甲基氯硅烷 在 dihydrogen hexachloroplatinate 作用下， 以 异丙醇 为溶剂， 生成 1--2--aethan
  参考文献：
  名称：

  Kuznetsova,V.P. et al., Journal of general chemistry of the USSR, 1964, vol. 34, p. 1875 - 1878

  摘要：

  DOI：

文献信息

• Nickel-catalyzed cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes
  作者：Jin-He Na、Hong-Jian Du、Jia-Wen Jing、Xue-Qiang Chu、Xiao-Chun Hang、Zhi-Liang Shen、Xiaocong Zhou、Haiqing Luo

  DOI：10.1016/j.jcat.2024.115636

  日期：2024.9

  fluorosulfates with vinyl chlorosilanes by using nickel as transition metal catalyst and manganese as reductant has been achieved. The reactions proceeded smoothly at room temperature via C-O bond activation to give a series of structurally varied aryl silanes in moderate to good yields, displaying broad substrate generality and good functional group compatibility. In addition, the reaction could be subjected

  以镍为过渡金属催化剂、锰为还原剂，实现了氟代硫酸芳基酯与乙烯基氯硅烷的高效交叉亲电偶联。反应在室温下通过C-O键活化顺利进行，以中等至良好的收率得到一系列结构多样的芳基硅烷，显示出广泛的底物通用性和良好的官能团相容性。此外，该反应可以进行放大合成并应用于生物活性分子的后期功能化。
• Steroidal silicon side-chain analogs as potential antifertility agents
  作者：Richard H. Peters、David F. Crowe、Masato Tanabe、Mitchell A. Avery、Wesley K. M. Chong

  DOI：10.1021/jm00387a011

  日期：1987.4

  A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized. Particularly noteworthy are a group of [(trialkylsilyl)ethynyl]estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity. The best compounds synthesized are 17 alpha-[(triethylsilyl)ethynyl]estradiol (5) and 17 alpha-[(tert-butyldimethylsilyl)ethynyl]estradiol (33), which show a separation of antifertility from estrogenic activity in the rat. The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Fe: Org.Verb.A5, 5.1.8.3, page 113 - 131
  作者：

  DOI：——

  日期：——
• Litkovits,A.K.; Yurzhenko,T.I., Doklady Chemistry, 1962, vol. 142, p. 140 - 142
  作者：Litkovits,A.K.、Yurzhenko,T.I.

  DOI：——

  日期：——
• Sokolova, E. B.; Massarskaya, S. M.; Dyatlova, V. G., Zhurnal Obshchei Khimii, 1973, vol. 43, p. 2684 - 2686
  作者：Sokolova, E. B.、Massarskaya, S. M.、Dyatlova, V. G.、Prokopova, L. K.

  DOI：——

  日期：——