2-(tritylthio)ethan-1-ammonium trifluoroacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-(tritylthio)ethan-1-ammonium trifluoroacetate
• 英文别名: 2,2,2-Trifluoroacetic acid;2-tritylsulfanylethanamine；2,2,2-trifluoroacetic acid;2-tritylsulfanylethanamine
• 化学式: C₂HF₃O₂*C₂₁H₂₁NS
• 分子量: 433.494
• InChiKey: HVVLOVWTYCNMRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(tritylthio)ethan-1-ammonium trifluoroacetate 在 碳酸氢钠 作用下， 以 水 、 乙酸乙酯 为溶剂， 生成 2-三苯甲硫基-乙胺盐酸盐
  参考文献：
  名称：

  Tc-labeled arylpiperazine derivatives for imaging serotonin receptor

  摘要：

  本发明涉及用于成像5-羟色胺受体的Tc标记的芳基哌嗪衍生物，更具体地说，涉及与MAMA-二硫化物、N2S2或二甲基-N2S2螯合配体偶联的芳基哌嗪衍生物，其化学式如下（1）。根据本发明的新芳基哌嗪衍生物在代谢中没有酰胺水解问题，对5-羟色胺受体具有高亲和力，并且可以与锝的最佳放射性核素标记，因此可以用于监测哺乳动物的神经退行性疾病或神经系统疾病，具有实用价值。

  公开号：

  US20070036715A1
• 作为产物：
  描述：

  三苯基甲醇 、 S-三苯甲基半胱胺盐酸盐 在 三氟乙酸 作用下， 以59 %的产率得到2-(tritylthio)ethan-1-ammonium trifluoroacetate
  参考文献：
  名称：

  通过 Au(III) 聚合物试剂进行高效端基官能化和二嵌段共聚物合成

  摘要：

  在此，我们描述了实验室稳定的有机金属 Au( III ) 封端聚合物试剂的合成。这些试剂介导含硫醇小分子和聚合物的化学选择性S-芳基化，分别产生官能化的单遥爪聚合物和二嵌段共聚物。这些转化在几分钟内快速进行，并在定量转化中产生缀合物，使该策略成为聚合物功能化工具箱的有力补充。

  DOI：

  10.1039/d3cc05350d

文献信息

• [EN] THIOL-NOTA DERIVATIVES FOR KIT 68GA RADIOLABELING<br/>[FR] DÉRIVÉS DE THIOL-NOTA POUR RADIOMARQUAGE PAR KIT 68GA
  申请人：UNIV MCGILL

  公开号：WO2010066051A1

  公开（公告）日：2010-06-17

  A thiol-NOTA derivative of Formula (I): wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 is described herein. The thiol-NOTA derivatives are suitable for kit 68Ga radiolabeling of proteins and peptides.

  本文描述了一种公式（I）的巯基-NOTA衍生物：其中n为1、2、3、4、5、6、7、8、9或10；m为1、2、3、4、5、6、7、8、9或10。这些巯基-NOTA衍生物适用于用于蛋白质和肽的68Ga标记的试剂盒。
• Stabilization of Inorganic Nanocrystals by Organic Dendrons
  作者：Y. Andrew Wang、J. Jack Li、Haiyan Chen、Xiaogang Peng

  DOI：10.1021/ja016711u

  日期：2002.3.1

  A series of hydrophilic organic dendron ligands was designed and synthesized for stabilizing high-quality semiconductor and noble metal nanocrystals. The focal point of the dendron ligands is chosen to be a thiol group which is a universal coordinating site for compound semiconductor and noble metal nanocrystals. The methods for binding these dendron ligands onto the surface of the nanocrystals are simple and straightforward. The thin, about 1-2 nm, but closely packed and tangled ligand she[[ provides sufficient stability for the "dendron-protected nanocrystals" to withstand the rigors of the coupling chemistry and the standard separation/purification techniques. The chemistry presented can be immediately applied for the development of a new generation of biomedical labeling reagents based on high-quality semiconductor nanocrystals. It also provides an alternative path to apply noble metal nanocrystals for developing sensitive detection schemes for chemical and biochemical purposes. The concept may further provide an optimal solution for many other problems encountered in nanocrystal-related research and development, for which the stability of the nanocrystals is a critical issue. Furthermore, the experimental results confirmed that the photochemical stability of colloidal semiconductor and noble metal nanocrystals is the key for developing reliable and reproducible processing chemistry for these nanocrystals.
• Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds
  作者：C. Wängler、B. Wängler、M. Eisenhut、U. Haberkorn、W. Mier

  DOI：10.1016/j.bmc.2007.11.044

  日期：2008.3

  DOTA (1,4,7,10-tetraazacyclodocecane-N,N',N",N'''-tetraacetic acid), which forms extremely stable complexes with a large number of metal ions, is one of the most important and most commonly used chelators for in vivo applications such as cancer diagnosis and therapy. However, many of the published synthesis protocols for DOTA derivatives are complicated and give the products in low yields. Here we report improved synthesis routes for tris-tBu-DOTA, tris-benzyl-DOTA, and thiol-DOTA, and also describe the synthesis of the novel compound tris-4-nitro-benzyl-DOTA. In addition, we determined the applicability of the DOTA derivatives tris-tBu-DOTA, thiol-DOTA, tris-benzyl-DOTA, tris-4-nitrobenzyl-DOTA, tris-allyl-DOTA, DOTA-PFP-ester, and DOTA-PNP-ester for multimerization reactions using amino functionalized PAMAM dendrimers of different sizes. Thiol-DOTA was found to be the best compound for efficient reactions with dendritic scaffolds generating highly homogeneous DOTA-multimers. This DOTA derivative could be quantitatively conjugated to a 128-mer dendrimer. (C) 2007 Elsevier Ltd. All rights reserved.
• Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of αVβ3 integrin
  作者：Marie Aufort、Marta Gonera、Nicolas Chaignon、Loïc Le Clainche、Christophe Dugave

  DOI：10.1016/j.ejmech.2009.02.022

  日期：2009.9

  We report the design of a new ligand of integrins that might be used for the molecular imaging of tumor neoangiogenesis. For this purpose, we designed a modified RGD tripeptide bearing a N-terminal N-bis(thioethyl)glycinate (NS2) motif and a thioethyl moiety at the C-terminus. Simultaneous coordination of an oxorhenium core by the NS2 and thioethyl moieties led to peptide cyclization and gave the corresponding monomers 13a and b (major isomer) resulting from the syn/anti-isomerism, along with dimers' species 16a and b. Cyclometallated peptide 13b showed the most promising activity with an IC50 of 86 nM for integrin alpha(V)beta(3) whereas it binds integrin a(IIb)beta(3) with an affinity lower by an order of magnitude. Labeling with [(99)mTc]oxotechnetium gluconate led exclusively to complex 17, the equivalent of compound 13b, which displayed satisfactory stabilities in mice plasma and towards glutathione. (C) 2009 Elsevier Masson SAS. All rights reserved.
• [EN] CROSSLINKED DISULPHIDE CONTAINING POLYMERS FOR DRUG DELIVERY<br/>[FR] POLYMERES RETICULES CONTENANT DU DISULFURE POUR L'ADMINISTRATION DE MEDICAMENTS
  申请人：KING S COLLEGE LONDON

  公开号：WO2002053624A1

  公开（公告）日：2002-07-11

  A polymer crosslinked by means of disulphide bonds and which degrades at low redox potential sites in the body (e.g. colon, the ischaemic heart, post-stroke brain, rheumatoid joints, tumours etc.) is used to form a delivery device for selective delivery of an active agent to the site. Monomers useful for producing disulphide crosslinked polymers are trithiiols of formula (I), where A = straight or branched alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; B = NH, NHCO or CONH; K = straight or branched alkyl; D = a bond, CONH-alkylidene or NHCO-alkylidene; R1 = H or NR12; R2 = H or COR11; R1 = H, alkyl, or an amino acid or peptide residue; R11 = OH, or an amino or peptide residue and alkyl is C¿1?-C6 alkyl.