Calcium;ZINC;hydroxide;phosphate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: Calcium;ZINC;hydroxide;phosphate
• 化学式: 8Ca*2HO*6O₄P*2Zn
• 分子量: 1055.25
• InChiKey: ZLMLAIUJWLRXKJ-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  -3.38
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  calcium hydrogen phosphate 、 zinc(II) dihydrogenphosphate dihydrate 、 calcium oxide 以 neat (no solvent) 为溶剂， 反应 0.5h， 生成 Calcium;ZINC;hydroxide;phosphate
  参考文献：
  名称：

  铜锌离子掺杂的羟基磷灰石固相机械化学合成特征

  摘要：

  这项工作表明，在行星式球磨机中处理反应混合物30分钟后，可以使用固相机械化学合成方法来获得掺杂有锌或铜离子的单相羟基磷灰石。为了理解在磷灰石结构中掺入掺杂元素的机理，已经研究了两个取代反应，即用铜或锌离子代替钙和氢氧根离子。研究表明，在合成材料中，掺杂离子主要占据钙离子的位置。每摩尔羟基磷灰石的取代度可以高达2摩尔取代基。获得的样品可用于生产具有抗菌特性的医用生物可吸收物品和涂层。

  DOI：

  10.1016/j.jssc.2021.121973

文献信息

• Adsorption and structural properties of hydroxy- and new lacunar apatites
  作者：Said Louihi、Hassan Noukrati、Youssef Tamraoui、Hamid Ait Said、Hicham Ben youcef、Bouchaib Manoun、Allal Barroug

  DOI：10.1016/j.molstruc.2019.127225

  日期：2020.2

  Abstract Design of novel phosphorus apatites, K2Pb6Zn2(PO4)6 and K2Pb4Ca4(PO4)6, zinc hydroxyapatite Ca8Zn2(PO4)6(OH)2, as well as hydroxyapatite Ca10(PO4)6(OH)2, and its corresponding calcined powder were conducted by means of two different synthesis protocols, i.e. solid state and wet chemical methods. The prepared materials adopt P63/m (No 176) as a space group. Structural refinements for K2Pb6Zn2(PO4)6

  摘要 新型磷磷灰石 K2Pb6Zn2(PO4)6 和 K2Pb4Ca4(PO4)6、锌羟基磷灰石 Ca8Zn2(PO4)6(OH)2 以及羟基磷灰石 Ca10(PO4)6(OH)2 及其相应煅烧粉末的设计通过两种不同的合成方案进行，即固态和湿化学方法。制备的材料采用P63/m（No 176）作为空间群。使用 Rietveld 方法对 K2Pb6Zn2(PO4)6 和 K2Pb4Ca4(PO4)6 腔隙磷灰石以及煅烧羟基磷灰石进行结构改进。对于 K2Pb6Zn2(PO4)6，精修结果表明大部分 Pb2+ 阳离子占据 (6h) 位点。本研究考察了合成条件对所制备材料的理化性质和表面反应性的影响。样品相对于蛋白质模型（牛血清白蛋白）的相互作用分析，在相同的实验条件下进行评估，揭示了沉淀样品的快速动力学过程，与通过固体化学反应获得的晶体相比。因此，前者在不到 20 分钟的时间内达到平衡条件，而后者则需要
• Development of Zinc-Doped Hydroxyapatite by Sol-Gel Method for Medical Applications
  作者：Catalin Negrila、Mihai Predoi、Simona Iconaru、Daniela Predoi

  DOI：10.3390/molecules23112986

  日期：——

  Zinc- (Zn) doped hydroxyapatite (HAp) were prepared by sol-gel method. Zinc-doped hydroxyapatite (ZnHAp) and HAp were analyzed by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The Rietveld analysis revealed that the HAp and 7ZnHAp powders obtained by sol-gel method have a monophasic hydroxyapatite structure belonging to the P63/m spatial group. The results obtained from the ultrasound characterization of HAp and ZnHAp are also presented in this study. The effect of zinc concentration on properties that were deduced from ultrasonic measurements are studied in the case of a significant zinc concentration (xZn = 0.07). From the values of the ultrasonic waves velocities were determined by the pairs of elastic coefficients of the suspensions (Young modulus E, Poisson coefficient ν), which have proven to be similar to those determined by other authors.

  采用溶胶-凝胶法制备了掺锌（Zn）羟基磷灰石（HAp）。通过 X 射线衍射 (XRD) 和 X 射线光电子能谱 (XPS) 对掺锌羟基磷灰石 (ZnHAp) 和 HAp 进行了分析。里特维尔德分析显示，溶胶凝胶法获得的 HAp 和 7ZnHAp 粉末具有单相羟基磷灰石结构，属于 P63/m 空间群。本研究还介绍了 HAp 和 ZnHAp 的超声表征结果。在锌浓度相当高（xZn = 0.07）的情况下，研究了锌浓度对超声波测量所推导出的特性的影响。根据超声波速度值确定了悬浮液的弹性系数对（杨氏模量 E 和泊松系数 ν），这些系数与其他作者确定的系数相似。
• Novel synthesis and crystallographic results of zinc substituted hydroxyapatite with high thermal stability
  作者：José R. Guerra-López、Ana E. Bianchi、Marcelo A. Ramos、Verónica Ferraresi-Curotto、Jorge A. Güida、Gustavo A. Echeverría

  DOI：10.1016/j.physb.2024.415676

  日期：2024.3

  data as well as those from thermal treated samples indicate that Zn(II) ions would exhibit some preference to occupy the Ca1 site, together with an appreciable amount of water incorporated in the structure, with the consequent reduction of crystallinity. The information obtained in the present work suggests that (Ca,Zn)Hap doped with zinc below 6.2 wt % has a thermal stability over 800 °C which results

  通过补充技术、X 射线粉末衍射 (XRPD)、热重分析(TGA) 和红外光谱 (FTIR)对掺杂不同量 Zn(II) 的羟基磷灰石 (CaHap) 进行了研究，后者包括对在不同温度下处理的样品进行检查。温度。所研究的样品是通过Ca(OH) 2、H 3 PO 4和ZnCl 2溶液的反应在98℃下通过沉淀法合成的。Rietveld 方法对 FTIR 和 XRPD 数据的分析表明，在低 Zn(II) 浓度下，Zn(II) 离子表现出一定程度的优先占据磷灰石结构的 Ca2 位点。然而，当 Zn(II) 浓度增加至 6.2 wt% 时，XRPD 和 FTIR 数据以及热处理样品的数据表明，Zn(II) 离子会表现出一定程度的占据 Ca1 位点的倾向，并且会出现相当大的量水掺入结构中，结晶度随之降低。 本工作中获得的信息表明，锌掺杂量低于 6.2 wt% 的 (Ca,Zn)Hap 具有超过 800 °C
• Structure Formation of Zinc-Substituted Hydroxyapatite during Mechanochemical Synthesis
  作者：M. V. Chaikina、N. V. Bulina、I. Yu. Prosanov、O. B. Vinokurova、A. V. Ishchenko

  DOI：10.1134/s0020168520040044

  日期：2020.4

  Zinc-substituted hydroxyapatite samples with a preset degree of substitution (Ca10-xZnx(PO4)(6)(OH)(2), x = 0.1-2.0) have been synthesized by a mechanochemical method. The composition of starting components ((Zn(H2PO4)(2) . 2H(2)O and ZnO) and water of crystallization have been shown to influence the apatite structure formation process and the degree of zinc substitution for calcium in the mechanochemical synthesis and annealing processes. When ZnO was used as a dopant, beta-tricalcium phosphate was observed to form as a reaction intermediate directly in the mill after 5-10 min of the reaction mixture milling and disappear after 20 min of milling. The final synthesis product-zinc-substituted hydroxyapatite-remains single-phase for x <= 0.8 in the case of Zn(H2PO4)(2) . 2H(2)O and x <= 0.25 in the case of ZnO. After annealing, the zinc-substituted hydroxyapatite is single-phase only in the case of zinc phosphate using at x <= 0.1.