lycoflexine N-oxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: lycoflexine N-oxide
• 化学式: C₁₇H₂₅NO₃
• 分子量: 291.39
• InChiKey: XXCSNGDVQSIJRK-UKKHPFIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  21.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.2
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  lycoflexine N-oxide 在 sodium azide 作用下， 以 水 为溶剂， 反应 0.08h， 生成 p-叠氮甲苯
  参考文献：
  名称：

  One-pot, efficient, and regioselective syntheses of 1,4-disubstituted 1,2,3-triazoles using aryldiazonium silica sulfates in water

  摘要：

  A one-pot, efficient, and straightforward procedure for the copper-catalyzed synthesis of 1,4-disubstituted 1,2,3-triazoles is studied by in situ generation of aryl azides via the reaction of aryldiazonium silica sulfates and sodium azide, followed by coupling with a terminal alkyne. These reactions are carried out in water at room temperature without using any additional ligands. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.081
• 作为产物：
  描述：

  lycoflexine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以69%的产率得到lycoflexine N-oxide
  参考文献：
  名称：

  从三个品种的十大新fawcettimine相关生物碱石松

  摘要：

  十新fawcettimine相关生物碱，即lycopoclavamines，lycoposquarrosamine-A，和其它羟基化的fawcettimine衍生物，从三个物种的分离石松（伸筋草，蛇足石松，和石松蓬）。通过光谱方法和化学相关性阐明了新生物碱的结构。

  DOI：

  10.1016/j.tet.2011.05.107

文献信息

• Aryldiazonium silica sulfates as efficient reagents for Heck-type arylation reactions under mild conditions
  作者：Amin Zarei、Leila Khazdooz、Azadeh Pirisedigh、Abdol R. Hajipour、Hojjat Seyedjamali、Hamidreza Aghaei

  DOI：10.1016/j.tetlet.2011.06.095

  日期：2011.8

  An efficient and straightforward procedure for Heck-type arylation reactions was studied using aryldiazonium silica sulfates and olefins in the presence of a catalytic amount of Pd(OAc)(2). These reactions were carried out in water at room temperature without using a base or additional ligands. The use of a non-toxic solvent, a simple and clean work-up, short reaction times, and good yields are advantages of this method. (C) 2011 Elsevier Ltd. All rights reserved.
• One-pot, efficient, and regioselective syntheses of 1,4-disubstituted 1,2,3-triazoles using aryldiazonium silica sulfates in water
  作者：Amin Zarei

  DOI：10.1016/j.tetlet.2012.07.081

  日期：2012.9

  A one-pot, efficient, and straightforward procedure for the copper-catalyzed synthesis of 1,4-disubstituted 1,2,3-triazoles is studied by in situ generation of aryl azides via the reaction of aryldiazonium silica sulfates and sodium azide, followed by coupling with a terminal alkyne. These reactions are carried out in water at room temperature without using any additional ligands. (C) 2012 Elsevier Ltd. All rights reserved.
• Ten new fawcettimine-related alkaloids from three species of Lycopodium
  作者：Kazuaki Katakawa、Hiroko Mito、Noriyuki Kogure、Mariko Kitajima、Sumphan Wongseripipatana、Munehisa Arisawa、Hiromitsu Takayama

  DOI：10.1016/j.tet.2011.05.107

  日期：2011.9

  fawcettimine-related alkaloids, i.e., lycopoclavamines, lycoposquarrosamine-A, and other hydroxylated fawcettimine derivatives, were isolated from three species of Lycopodium (Lycopodium clavatum, Lycopodium serratum, and Lycopodium squarrosum). The structures of the new alkaloids were elucidated by spectroscopic methods and chemical correlation.

  十新fawcettimine相关生物碱，即lycopoclavamines，lycoposquarrosamine-A，和其它羟基化的fawcettimine衍生物，从三个物种的分离石松（伸筋草，蛇足石松，和石松蓬）。通过光谱方法和化学相关性阐明了新生物碱的结构。