5'-O-tritylpseudouridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-tritylpseudouridine
• 英文别名: 5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
• 化学式: C₂₈H₂₆N₂O₆
• 分子量: 486.524
• InChiKey: MAYWCGAUMHNLFX-VPBXCIAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三苯基氯甲烷 、 假尿苷 在 吡啶 作用下， 反应 24.0h， 以66%的产率得到5'-O-tritylpseudouridine
  参考文献：
  名称：

  EP1897878

  摘要：

  公开号：

文献信息

• STABLE CRYSTAL OF PROTECTED PSEUDOURIDINE
  申请人：YAMASA CORPORATION

  公开号：EP1897878A1

  公开（公告）日：2008-03-12

  The invention provides a stable and high-purity protected pseudouridine in crystal form represented by the following structural formula: (wherein M represents a trityl group or a derivative thereof), which is a useful material for producing an RNA oligomer or a similar substance. The invention also provides a method for producing the crystalline protected pseudouridine, which method includes crystallizing a protected pseudouridine from a solution containing the protected pseudouridine, by use of an ester solvent and/or an alcoholic solvent. The method, which does not need a silica gel column treatment, can be performed in a simple manner, does not impose a load on the environment, and realizes low-cost production of a target crystalline protected pseudouridine.

  本发明提供了一种稳定的高纯度晶体状受保护假尿苷，其结构式如下： (其中 M 代表三苯甲基或其衍生物），它是生产 RNA 低聚物或类似物质的有用材料。 本发明还提供了一种生产结晶的受保护的假尿苷的方法，该方法包括通过使用酯溶剂和/或醇溶剂，从含有受保护的假尿苷的溶液中结晶出受保护的假尿苷。该方法无需硅胶柱处理，操作简单，不会对环境造成负担，可实现低成本生产受保护的目标结晶假尿嘧啶。
• STABLE CYSTAL OF PROTECTED PSEUDOURIDINE
  申请人：Kitano Kenji

  公开号：US20100216985A1

  公开（公告）日：2010-08-26

  A stable and high-purity protected pseudouridine in crystal form is provided represented by the following structural formula: wherein M represents a trityl group or a derivative thereof, which is a useful material for producing an RNA oligomer or a similar substance. A method for producing the crystalline protected pseudouridine is also provided, which method includes crystallizing a protected pseudouridine from a solution containing the protected pseudouridine, by use of an ester solvent and/or an alcoholic solvent. The method, which does not need a silica gel column treatment, can be performed in a simple manner, does not impose a load on the environment, and realizes low-cost production of a target crystalline protected pseudouridine.
• US7968521B2
  申请人：——

  公开号：US7968521B2

  公开（公告）日：2011-06-28
• EP1897878
  申请人：——

  公开号：——

  公开（公告）日：——