cis-[Pt(dach)I2]

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: cis-[Pt(dach)I2]
• 英文别名: [(1S,2S)-2-azanidylcyclohexyl]azanide;diiodoplatinum(2+)
• 化学式: C₆H₁₂I₂N₂Pt
• 分子量: 561.064
• InChiKey: KEZVWGKGXZSYRH-VDBFCSKJSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-[Pt(dach)I2] 、 silver oxalate 以 水 为溶剂， 反应 3.0h， 生成 oxaliplatin
  参考文献：
  名称：

  DNA binding studies of a series of cis-[Pt(Am)2X2] complexes (Am=inert amine, X=labile carboxylato ligand)

  摘要：

  A series of platinum(II) complexes of formulae cis-[Pt(Am)(2)X-2] (where Am represents an inert amine and X a labile (carboxylato) ligand) have been prepared and characterized by elemental analysis, ESI-MS, IR and H-1 NMR spectroscopy. The single-crystal molecular structures were determined for cis-[Pt(opea)(cbdca-2H)], cis-[Pt(hmpy)(cbdca-2H)], cis-[Pt(NH3)(2)(bzmal-2H)] and cis-[Pt(hmpy)(mu-dcch-2H)(2)] (where opea is picolylamine, hmpy represents 4-hydroxymethylpyridine, cbdca-2H, is 1,1-cyclobutanedicarboxylate anion, bzmal-2H stands for benzylmalonate anion and dcch-2H is trans-1,2-cyclohexanedicarboxylate anion). The interaction of all compounds with DNA was investigated with different techniques: viscosity measurements and emission fluorescence spectroscopy were used to investigate the changes induced by the binding of the platinum compounds to calf-thymus DNA, while atomic force microscopy and electrophoretic mobility allowed evaluating the potential alterations of pBR322 plasmid DNA. The cytotoxic behavior of the platinum compounds on human leukemia HL-60 tumor cell lines was also examined. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.07.018
• 作为产物：
  描述：

  、 (1R,2R)-1,2-diaminocyclohexane 以 水 为溶剂， 反应 1.0h， 生成 cis-[Pt(dach)I2]
  参考文献：
  名称：

  DNA binding studies of a series of cis-[Pt(Am)2X2] complexes (Am=inert amine, X=labile carboxylato ligand)

  摘要：

  A series of platinum(II) complexes of formulae cis-[Pt(Am)(2)X-2] (where Am represents an inert amine and X a labile (carboxylato) ligand) have been prepared and characterized by elemental analysis, ESI-MS, IR and H-1 NMR spectroscopy. The single-crystal molecular structures were determined for cis-[Pt(opea)(cbdca-2H)], cis-[Pt(hmpy)(cbdca-2H)], cis-[Pt(NH3)(2)(bzmal-2H)] and cis-[Pt(hmpy)(mu-dcch-2H)(2)] (where opea is picolylamine, hmpy represents 4-hydroxymethylpyridine, cbdca-2H, is 1,1-cyclobutanedicarboxylate anion, bzmal-2H stands for benzylmalonate anion and dcch-2H is trans-1,2-cyclohexanedicarboxylate anion). The interaction of all compounds with DNA was investigated with different techniques: viscosity measurements and emission fluorescence spectroscopy were used to investigate the changes induced by the binding of the platinum compounds to calf-thymus DNA, while atomic force microscopy and electrophoretic mobility allowed evaluating the potential alterations of pBR322 plasmid DNA. The cytotoxic behavior of the platinum compounds on human leukemia HL-60 tumor cell lines was also examined. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.07.018

文献信息

• DNA binding studies of a series of cis-[Pt(Am)2X2] complexes (Am=inert amine, X=labile carboxylato ligand)
  作者：Esther Escribano、Mercè Font-Bardia、Teresa Calvet、Julia Lorenzo、Patrick Gamez、Virtudes Moreno

  DOI：10.1016/j.ica.2012.07.018

  日期：2013.1

  A series of platinum(II) complexes of formulae cis-[Pt(Am)(2)X-2] (where Am represents an inert amine and X a labile (carboxylato) ligand) have been prepared and characterized by elemental analysis, ESI-MS, IR and H-1 NMR spectroscopy. The single-crystal molecular structures were determined for cis-[Pt(opea)(cbdca-2H)], cis-[Pt(hmpy)(cbdca-2H)], cis-[Pt(NH3)(2)(bzmal-2H)] and cis-[Pt(hmpy)(mu-dcch-2H)(2)] (where opea is picolylamine, hmpy represents 4-hydroxymethylpyridine, cbdca-2H, is 1,1-cyclobutanedicarboxylate anion, bzmal-2H stands for benzylmalonate anion and dcch-2H is trans-1,2-cyclohexanedicarboxylate anion). The interaction of all compounds with DNA was investigated with different techniques: viscosity measurements and emission fluorescence spectroscopy were used to investigate the changes induced by the binding of the platinum compounds to calf-thymus DNA, while atomic force microscopy and electrophoretic mobility allowed evaluating the potential alterations of pBR322 plasmid DNA. The cytotoxic behavior of the platinum compounds on human leukemia HL-60 tumor cell lines was also examined. (C) 2012 Elsevier B. V. All rights reserved.