3-(tert-butyl)-4-hydroxyphenyl 4-methylbenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 3-(tert-butyl)-4-hydroxyphenyl 4-methylbenzoate
• 英文别名: (3-Tert-butyl-4-hydroxyphenyl) 4-methylbenzoate
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: KEQGACGPJXTTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲基苯甲酸 、 特丁基对苯二酚 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以94%的产率得到3-(tert-butyl)-4-hydroxyphenyl 4-methylbenzoate
  参考文献：
  名称：

  Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists

  摘要：

  3-(tert-Butyl)-4-hydroxyphenyl 2,4-dichlorobenzoate (1) was discovered in our in-house high throughput screening as a moderate FXR antagonist. To improve the potency and the stability of the hit 1, forty derivatives were synthesized and SAR was systematically explored. The results turn out that replacing the 2,4-dichlorophenyl with 2,6-dichloro-4-amidophenyl shows great improvement in potency, replacing the benzoate with benzamide shows improvement in stability and slight declining of potency and 3-(tert-butyl)-4-hydroxyphenyl unit is essential in obtaining the FXR antagonistic activity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.08.021

文献信息

• Palladium-catalyzed carbonylative synthesis of aryl esters from <i>p</i>-benzoquinones and aryl triflates
  作者：Siqi Wang、Jian-Shu Wang、Zhengjie Le、Jun Ying、Xiao-Feng Wu

  DOI：10.1039/d1ob01400e

  日期：——

  A palladium-catalyzed dicarbonylation of p-benzoquinones with aryl triflates has been developed. Using Cr(CO)6 as the CO source, the reaction proceeds smoothly and efficiently to give a series of aryl esters in moderate to good yields (up to 90%).

  已经开发了对苯醌与芳基三氟甲磺酸酯的钯催化二羰基化反应。使用 Cr(CO) 6作为 CO 源，该反应顺利且高效地进行，以中等至良好的收率（高达 90%）得到一系列芳基酯。