匹考群 | 64063-57-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: 匹考群
• 英文名称: 5-trityl-pyridine-2-carboxylic acid
• 英文别名: 5(Triphenylmethyl)-Picolinic Acid；Picotrin；5-tritylpyridine-2-carboxylic acid
• CAS: 64063-57-6
• 化学式: C₂₅H₁₉NO₂
• 分子量: 365.431
• InChiKey: GDHQAOKGZLRWCG-UHFFFAOYSA-N

物化性质

• 沸点：
  531.7±38.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  匹考群 、 二乙醇胺 在 乙醇 作用下， 以 乙醇 为溶剂， 以to give the title compound, m.p. 206-209°的产率得到Picotrin diolamine
  参考文献：
  名称：

  2-Cyano-5-(substituted triphenylmethyl) pyridines

  摘要：

  本文披露了新型的5-三苯甲基吡啶羧酸、酰胺、酯及其药学上可接受的盐。还披露了使用所述新型化合物作为抗痤疮剂的方法。

  公开号：

  US04123433A1

文献信息

• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• Trityl picolinic acid derivatives and their use as anti-acne agents
  申请人：Schering Corporation

  公开号：US04044140A1

  公开（公告）日：1977-08-23

  Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.

  本文披露了新型的5-三苯甲基吡啶甲酸、酰胺、酯及其药学上可接受的盐。同时，还披露了将这些新型化合物用作抗痤疮剂的方法。
• 2-Cyano-5-(substituted triphenylmethyl) pyridines
  申请人：Schering Corporation

  公开号：US04123433A1

  公开（公告）日：1978-10-31

  Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.

  本文披露了新型的5-三苯甲基吡啶羧酸、酰胺、酯及其药学上可接受的盐。还披露了使用所述新型化合物作为抗痤疮剂的方法。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• DHA-PHARMACEUTICAL AGENT CONJUGATES
  申请人：Neuromedica, Inc.

  公开号：EP0909183A2

  公开（公告）日：1999-04-21