4,4'-dipivaloyloxyazobenzene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 4,4'-dipivaloyloxyazobenzene
• 英文别名: 2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-propionyloxy)-phenylazo]-phenyl ester；[4-[[4-(2,2-dimethylpropanoyloxy)phenyl]diazenyl]phenyl] 2,2-dimethylpropanoate
• 化学式: C₂₂H₂₆N₂O₄
• 分子量: 382.459
• InChiKey: RKGKVNHGLLXEBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,2-二甲基丙酰溴 、 4,4’-二羟基偶氮苯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以63%的产率得到4,4'-dipivaloyloxyazobenzene
  参考文献：
  名称：

  Mechano-isomerization of azobenzene

  摘要：

  我们展示了超声波诱导的机械力能在不切断偶氮键的情况下将位于聚甲基丙烯酸酯聚合物中心的偶氮苯异构体从顺式转变为反式构型。异构化速率不受溶剂极性的影响，表明异构化过程是通过非极性的反转过渡态发生的。

  DOI：

  10.1039/c3cc43797c

文献信息

• Phenolic ester derivatives as elastase inhibitors
  申请人：G. D. Searle & Co.

  公开号：US04683241A1

  公开（公告）日：1987-07-28

  Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.

  通式I的酚酸酯化合物##STR1##可用于预防、治疗或缓解弹性蛋白酶介导的疾病或症状。
• (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase
  作者：Masateru Miyano、James R. Deason、Akira Nakao、Michael A. Stealey、Clara I. Villamil、Daniel D. Sohn、Richard A. Mueller

  DOI：10.1021/jm00400a030

  日期：1988.5

  A series of 4-(acyloxy)- and 4,4'-bis(acyloxy)benzophenones were synthesized. Some of them, pivalates (trimethylacetates) and isobutyrates in particular, were found to be potent and selective inhibitors of human neutrophil (leukocyte) elastase. A series of 2-[(acyloxy)methyl]-5-(acyloxy)-4-pyrones were synthesized regioselectively from kojic acid. The 4-pyrones bearing a long chain acyl group at the 2-position and either pivaloyloxy or isobutyryloxy at the 5-position were potent and selective inhibitors of the human elastase. A number of analogues and derivatives in both series were synthesized in order to study the structure-activity relationship as summarized in Tables I-VI and in Tables IX and X. The inhibition was selective to human neutrophil elastase. No inhibition of porcine pancreatic elastase or bovine pancreatic chymotrypsin (Tables VII and XI) was observed. The most likely mechanism of inhibition is discussed. The implication of these findings for the treatment of rheumatoid arthritis and emphysema is outlined.
• Mechano-isomerization of azobenzene
  作者：Sravan K. Surampudi、Harik R. Patel、G. Nagarjuna、D. Venkataraman

  DOI：10.1039/c3cc43797c

  日期：——

  We show that ultrasound-induced mechanical force isomerizes an azobenzene centered within a poly(methyl acrylate) polymer from cis to trans configuration without cleaving the azo bond. The isomerization rate was not altered by the polarity of the solvent indicating that the isomerization occurs through a non-polar, inversion transition state.

  我们展示了超声波诱导的机械力能在不切断偶氮键的情况下将位于聚甲基丙烯酸酯聚合物中心的偶氮苯异构体从顺式转变为反式构型。异构化速率不受溶剂极性的影响，表明异构化过程是通过非极性的反转过渡态发生的。