6-(cyclohexylamino)-1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydrofuro[2,3-d]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 英文名称: 6-(cyclohexylamino)-1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydrofuro[2,3-d]pyrimidine-2,4-dione
• 英文别名: 6-(cyclohexylamino)-1,3-dimethyl-5-phenylfuro[2,3-d]pyrimidine-2,4(1H,3H)-dione；6-(Cyclohexylamino)-1,3-dimethyl-5-phenylfuro[2,3-d]pyrimidine-2,4-dione
• 化学式: C₂₀H₂₃N₃O₃
• 分子量: 353.421
• InChiKey: XOMBMGAPVMZEDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异氰环已烷 、 5-benzylidene-1,3-dimethyl-pyrimidine-2,4,6-trione 以 N,N-二甲基甲酰胺 为溶剂， 以92%的产率得到6-(cyclohexylamino)-1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydrofuro[2,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  10.3184/174751911x556765

  摘要：

  DOI：

  10.3184/174751911x556765

文献信息

• Tandem oxidative isocyanide-based cycloaddition reactions in the presence of MIL-101(Cr) as a reusable solid catalyst
  作者：Ahmad Shaabani、Heshmatollah Sepahvand、Mostafa M. Amini、Alireza Hashemzadeh、Mahmoud Borjian Boroujeni、Elham Badali

  DOI：10.1016/j.tet.2018.02.046

  日期：2018.4

  The tandem oxidative three-component synthesis of two types of the heterocycles such as furans and imidazopyridines, via isocyanides [1+4] cycloaddition reactions in the presence of MIL-101(Cr) under aerobic conditions are reported. When the 4-toluenesulfonylmethyl isocyanide was used, an unexpected [3+2] cycloaddition reaction of isocyanides with aldehydes accomplished and dihydrophenyloxazoles and

  报道了在有氧条件下，在MIL-101（Cr）存在下，通过异氰酸酯[1 + 4]环加成反应，串联合成了两种类型的杂环（例如呋喃和咪唑并吡啶）的氧化三组分串联反应。当使用4-甲苯磺酰基甲基异氰酸酯时，异氰酸酯与醛的意外的[3 + 2]环加成反应完成，并生成了二氢苯基恶唑和苯基恶唑。这些合成成功地使用了广泛的底物进行。
• Ionic Liquid Promoted One-Pot Synthesis of Furo[2,3-d]pyrimidine-2,4(1H,3H)-diones
  作者：Ahmad Shaabani、Ebrahim Soleimani、Maria Darvishi

  DOI：10.1007/s00706-006-0558-1

  日期：2007.1

  The three-component condensation of aldehyde, N,N'-dimethylbarbituric acid and alkyl or aryl isocyanide afforded the corresponding furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in 1-butyl-3-methylimidazolium bromide as an ionic liquid in high yields at room temperature within several minutes.
• Microwave‐Assisted Three‐Component Condensation on Montmorillonite K10: Solvent‐Free Synthesis of Furopyrimidines, Furocoumarins, and Furopyranones
  作者：Ahmad Shaabani、Mohammad Bagher Teimouri、Sima Samadi、Kamal Soleimani

  DOI：10.1081/scc-200049779

  日期：2005.3

  Rapid and efficient one-pot three-component condensation synthesis of furopyrimidines, furocoumarins, and furopyranones are described which occur in the presence of montmorillonite K10 using microwave irradiation under solvent-free conditions.
• 10.3184/174751911x556765
  作者：Shaabani, Ahamd、Teimouri, Mohammad Bagher、Afgheh, Mohammad、Eskandari, Mehrdad

  DOI：10.3184/174751911x556765

  日期：——