4-氯-6-甲基-呋喃并[2,3-d]嘧啶 | 24889-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 中文名称: 4-氯-6-甲基-呋喃并[2,3-d]嘧啶
• 中文别名: 4-氯-6-甲基呋喃[2,3-D]嘧啶
• 英文名称: 4-chloro-6-methylfuro[2,3-d]pyrimidine
• 英文别名: 4-Chlor-6-methylfuro<2,3-d>pyrimidin；6-methyl-4-chlorofuro[2,3-d]pyrimidine
• CAS: 24889-21-2
• 化学式: C₇H₅ClN₂O
• mdl: MFCD11215556
• 分子量: 168.583
• InChiKey: SGADWDZEFVJPHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4-氯-6-甲基-呋喃并[2,3-d]嘧啶 在 ammonium hydroxide 作用下， 生成 6-甲基呋喃并[2,3-d]嘧啶-4-胺
  参考文献：
  名称：

  Marquet; Andre-Louisfert; Bisagni, Bulletin de la Societe Chimique de France, 1969, vol. 12, p. 4344 - 4348

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基呋喃并[2,3-d]嘧啶-4(3H)-酮 在 三氯氧磷 作用下， 生成 4-氯-6-甲基-呋喃并[2,3-d]嘧啶
  参考文献：
  名称：

  Marquet; Andre-Louisfert; Bisagni, Bulletin de la Societe Chimique de France, 1969, vol. 12, p. 4344 - 4348

  摘要：

  DOI：

文献信息

• [EN] CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY<br/>[FR] PYRIDINES CONDENSEES ET PYRIMIDINES A ACTIVITE TIE2 (TEK)
  申请人：ASTRAZENECA AB

  公开号：WO2004013141A1

  公开（公告）日：2004-02-12

  A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I); G is selected from O, S and NR5; Z is selected from N and CR6; Q1 is selected from optionally substituted aryl and heteroaryl, and the substituents R1 to R6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

  化合物的公式（I），其中A与其连接的碳原子一起形成一个融合的5-成员杂环芳烃环，其中所述的杂环芳烃环包含1个或2个从O、N和S中选择的杂原子，并且包含G的5-成员环与在公式（I）中标记为桥头碳#的A形成的环在间位连接；G从O、S和NR5中选择；Z从N和CR6中选择；Q1从可选择的取代芳基和杂环芳基中选择，取代基R1到R6如文本中所定义，用于在温血动物（如人）中产生抗血管生成作用。
• Condensed pyridines and pyrimidines with tie2 (tek) activity
  申请人：Luke Arthur Richard William

  公开号：US20050256140A1

  公开（公告）日：2005-11-17

  A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR 5 ; Z is selected from N and CR 6 ; Q 1 is selected from optionally substituted aryl and heteroaryl, and the substituents R 1 to R 6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

  化合物的式子（I），其中A与其连接的碳原子一起形成一个融合的5元杂环芳基环，其中该杂环芳基环含有1或2个从O，N和S中选择的杂原子，并且含有G的5元环与在式子（I）中被标记为#的桥头碳上的A形成的环在间位连接：G从O，S和NR5中选择；Z从N和CR6中选择；Q1从可选取代的芳基和杂环基中选择，取代基R1到R6如文本中所定义，用于在温血动物如人中产生抗血管生成效应的制备。
• Furopyrimidine derivatives
  申请人：DowElanco

  公开号：US05486516A1

  公开（公告）日：1996-01-23

  Pesticidal compounds of the formula (1) ##STR1## R.sup.1 is H, C.sub.1 -C.sub.4 alkyl, or phenyl optionally substituted with halo, (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy, halo (C.sub.1 -C.sub.4) alkyl, or halo (C.sub.1 -C.sub.4) alkoxy; R.sup.2 is H, (C.sub.1 -C.sub.4) alkyl, nitro, halo; or R.sup.1 and R.sup.2 combine to form --(CH.sub.2).sub.4 --; R.sup.3 is H, (C.sub.1 -C.sub.4) alkyl, halo (C.sub.1 -C.sub.4) alkyl, phenyl, or substituted phenyl; X is O, S, NR.sup.4, or CR.sup.5 R.sup.6 ; and Y is a bond or an alkylene chain one to six carbon atoms long; and Z is (a) (C.sub.3 -C.sub.8) cycloalkyl or cycloalkenyl, optionally substituted with (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy, halo (C.sub.1 -C.sub.4) alkyl, halo (C.sub.1 -C.sub.4) alkoxy, halo, hydroxy or (C.sub.1 -C.sub.4) alkanoyl; (b) a phenyl group of the formula (2) ##STR2## (c) a furyl group of formula (3) ##STR3## (d) a thienyl group of the formula (4) ##STR4## (e) a group of formula (5) or (6) ##STR5## (f) a group selected from optionally substituted naphthyl, dihydronaphthyl, tetrahydronaphthyl, and decahydronaphthyl; optionally substituted pyridyl; optionally substituted indolyl; 1,3-benzodioxolyl; 2,6-dimethyl-4-morpholinyl; and 1-adamantyl; and acid addition salts compounds of formula (1); and pesticidal compositions and pesiticide methods utilizing compounds of formula (1).

  式（1）的杀虫化合物##STR1## 其中R.sup.1为H，C.sub.1-C.sub.4烷基或苯基，可选用卤素，（C.sub.1-C.sub.4）烷基，（C.sub.1-C.sub.4）烷氧基，卤代（C.sub.1-C.sub.4）烷基或卤代（C.sub.1-C.sub.4）烷氧基进行取代；R.sup.2为H，（C.sub.1-C.sub.4）烷基，硝基或卤素；或R.sup.1和R.sup.2结合形成--（CH.sub.2）.sub.4--；R.sup.3为H，（C.sub.1-C.sub.4）烷基，卤代（C.sub.1-C.sub.4）烷基，苯基或取代苯基；X为O，S，NR.sup.4或CR.sup.5R.sup.6；Y为键或长度为1至6个碳原子的烷基链；Z为（a）（C.sub.3-C.sub.8）环烷基或环烯基，可选用（C.sub.1-C.sub.4）烷基，（C.sub.1-C.sub.4）烷氧基，卤代（C.sub.1-C.sub.4）烷基，卤代（C.sub.1-C.sub.4）烷氧基，卤素，羟基或（C.sub.1-C.sub.4）烷酰基进行取代；（b）公式（2）的苯基##STR2## （c）公式（3）的呋喃基##STR3## （d）公式（4）的噻吩基##STR4## （e）公式（5）或（6）的基团##STR5## （f）从可选用取代的萘基，二氢萘基，四氢萘基和十氢萘基；可选用取代的吡啶基；可选用取代的吲哚基；1,3-苯并二氧杂环基；2,6-二甲基-4-吗啉基；和1-金刚烷基中选择的基团；以及公式（1）化合物的酸加成盐和利用公式（1）化合物的杀虫剂组合物和杀虫剂方法。
• Condensed pyridines and pyrimidines with tie2 (TEK) activity
  申请人：AstraZeneca AB

  公开号：US07427616B2

  公开（公告）日：2008-09-23

  A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR5; Z is selected from N and CR6; Q1 is selected from optionally substituted aryl and heteroaryl, and the substituents R1 to R6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

  化合物的公式（I），其中A与其连接的碳原子共同形成一个融合的五元杂环芳基环，其中所述杂环芳基环包含从O、N和S中选择的1或2个杂原子，且含有G的五元环与在公式（I）中由A形成的环在桥头碳标记#的间位相连：G从O、S和NR5中选择；Z从N和CR6中选择；Q1从可选取代的芳基和杂芳基中选择，取代基R1至R6在文本中定义，用于在温血动物如人体中产生抗血管生成效应。
• [EN] BAX INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE BAX ET LEURS UTILISATIONS
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2021002986A3

  公开（公告）日：2021-05-27