1,3,3,5-Tetramethyl-6-azabicyclo[3.2.1]octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 1,3,3,5-Tetramethyl-6-azabicyclo[3.2.1]octane
• 化学式: C₁₁H₂₁N
• 分子量: 167.29
• InChiKey: KJNPYCPXGWCVRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• AZABICYCLIC, AZATRICYCLIC AND AZASPIROCYCLIC DERIVATIVES OF AMINOCYCLOHEXANE AS NMDA, 5HT3, AND NEURONAL NICOTINIC RECEPTOR ANTAGONISTS
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP1485086A1

  公开（公告）日：2004-12-15
• [EN] AZABICYCLIC, AZATRICYCLIC AND AZASPIROCYCLIC DERIVATIVES OF AMINOCYCLOHEXANE NMDA, 5HT3, AND NEURONAL NICOTINIC RECEPTOR ANTAGONI STS<br/>[FR] DERIVES AZABICYCLIQUES, AZATRICYCLIQUES ET AZASPIROCYCLIQUES D'AMINOCYCLOHEXANES COMME ANTAGONISTES DES RECEPTEURS DE NMDA, DES RECEPTEURS DE 5HT3 ET DES RECEPTEURS NICOTINIQUES NEURONAUX
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2003080046A1

  公开（公告）日：2003-10-02

  Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes of formula I (N, Y, Z,, R, R1-R5 as defined in the claims) which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.