4,6-dichloro-1,3,5-triazine-2-carboxylic Acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4,6-dichloro-1,3,5-triazine-2-carboxylic Acid
• 化学式: C₄HCl₂N₃O₂
• 分子量: 193.97
• InChiKey: DYORXYGCTYIKOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS<br/>[FR] PYRIMIDINE DIOL AMIDES COMME BLOQUEURS DES CANAUX SODIQUES
  申请人：PURDUE PHARMA LP

  公开号：WO2013072758A1

  公开（公告）日：2013-05-23

  The present disclosure provides pyrimidine diol amides of Formula (I), and the pharmaceutically acceptable solvates and prodrugs thereof, wherein A1, X, A2, W1, W2, W3, R1, R2, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式（I）的嘧啶二醇酰胺，以及其在药学上可接受的溶剂结晶和前药，其中A1、X、A2、W1、W2、W3、R1、R2和R4的定义如规范中所述。本公开还涉及使用式（I）的化合物来治疗对钠通道阻滞有反应的疾病。本公开的化合物特别适用于治疗疼痛。
• NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX
  申请人：Cleave Biosciences, Inc.

  公开号：US20160355503A1

  公开（公告）日：2016-12-08

  Nitrogen hexacycle compounds having an arylalkyl amine substituent at the P4 position and a substituted 5:6 bicyclic group at the P2 position of the nitrogen hexacycle as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the nitrogen hexacycle, the aryl alkyl group and the 5:6 bicyclic group are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.

  本发明涉及一种氮六环化合物，其在P4位置具有芳基烷基胺取代基，在氮六环的P2位置具有取代的5:6双环基团，并在氮六环的其他位置，芳基烷基基团和5:6双环基团的其他位置上可选地取代有脂肪族、功能性和/或芳香性组分。这些化合物是AAA蛋白酶体复合物的p97抑制剂，并且是治疗与p97生物活性相关的疾病，如癌症的有效药物。
• PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS
  申请人：Purdue Pharma L.P.

  公开号：US20140315783A1

  公开（公告）日：2014-10-23

  The present disclosure provides pyrimidine diol amides of Formula (I), and the pharmaceutically acceptable solvates and prodrugs thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , R 1 , R 2 , and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供式(I)的嘧啶二醇酰胺，以及其药学上可接受的溶剂和前药。其中，A1，X，A2，W1，W2，W3，R1，R2和R4如规范中所述。本公开还涉及使用式(I)的化合物治疗对钠通道阻滞有反应的疾病。本公开的化合物特别适用于治疗疼痛。
• US6337368B1
  申请人：——

  公开号：US6337368B1

  公开（公告）日：2002-01-08
• US9133131B2
  申请人：——

  公开号：US9133131B2

  公开（公告）日：2015-09-15