2-(4-triphenylmethoxy)benzylamino-2-methyl-propanamide | 226708-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-(4-triphenylmethoxy)benzylamino-2-methyl-propanamide
• 英文别名: 2-Methyl-2-[(4-trityloxyphenyl)methylamino]propanamide
• CAS: 226708-71-0
• 化学式: C₃₀H₃₀N₂O₂
• 分子量: 450.58
• InChiKey: HNKXGGMTIHFTQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Substituted 2-aminoacetamides and the use thereof
  申请人：Euro-Celtique S.A.

  公开号：US20020016464A1

  公开（公告）日：2002-02-07

  This invention is related to substituted 2-aminoacetamides represented by formula (II): or a pharmaceutically acceptable salt or prodrug thereof, wherein the substituents are defined herein. The invention also is directed to the use of substituted 2-aminoacetamides for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of pain, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及由公式（II）表示的取代的2-氨基乙酰胺或其药学上可接受的盐或前药，其中所述取代基在此定义。本发明还涉及使用取代的2-氨基乙酰胺治疗全局和局部缺血后的神经损伤，治疗或预防神经退行性疾病如肌萎缩侧索硬化症（ALS），以及作为抗癫痫药物、抗抑郁药物、局部麻醉剂、抗心律失常药物以及治疗或预防糖尿病神经病变。
• Substituted 2-Aminoacetamides and the Use Thereof
  申请人：Purdue Neuroscience Company

  公开号：EP2201944A2

  公开（公告）日：2010-06-30

  This invention relates to a compound having the Formula (II): or a pharmaceutically acceptable salt or prodrug thereof, wherein the substituents are defined herein, for use in a method of treating, preventing or ameliorating manic depression.

  本发明涉及一种具有式 (II) 的化合物： 或其药学上可接受的盐或原药，其中取代基在本文中定义，用于治疗、预防或改善躁狂抑郁症的方法。
• Sodium channel blocker compositions and the use thereof
  申请人：——

  公开号：US20020037926A1

  公开（公告）日：2002-03-28

  Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are pharmaceutical compositions and kits for the treatment or prevention of chronic pain or convulsion.

  本发明公开了通过向动物施用钠通道阻滞剂以及加巴喷丁和普瑞巴林中的至少一种来治疗或预防慢性疼痛或抽搐的方法。还公开了用于治疗或预防慢性疼痛或抽搐的药物组合物和试剂盒。
• EP1032377A4
  申请人：——

  公开号：EP1032377A4

  公开（公告）日：2006-06-14
• SUBSTITUTED 2-AMINOACETAMIDES AND THE USE THEREOF
  申请人：Euro-Celtique S.A.

  公开号：EP1032377A1

  公开（公告）日：2000-09-06