Pyrrophenone

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Pyrrophenone
• 英文别名: N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide
• 化学式: C₄₉H₃₇F₂N₃O₅S₂
• 分子量: 850.0
• InChiKey: XSCZRVUQXBBTRO-MKNPRXRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  61
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  163
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• USE OF ARACHIDONYL TRIFLUOROMETHYL KETONE
  申请人：Mosaiques Diagnostics And Therapeutics AG

  公开号：EP3677259A1

  公开（公告）日：2020-07-08

  The present invention is related to an inhibitor of cytosolic human phospholipase A2 (cPLA2) activity for use in the treatment of a subject suffering from or being at risk of suffering from a disease caused by or associated with vascular calcification.

  本发明涉及一种细胞质人磷脂酶 A2 (cPLA2)活性抑制剂，用于治疗由血管钙化引起或与血管钙化相关的疾病患者或有患病风险的患者。
• [EN] COMPOUND INDUCING LBPA ACCUMULATION FOR INHIBITING CELL-TO-CELL TRANSMISSION OF HIV<br/>[FR] COMPOSÉ INDUISANT UNE ACCUMULATION DE LBPA POUR INHIBER LA TRANSMISSION INTERCELLULAIRE DU VIH
  申请人：INST NAT SANTE RECH MED

  公开号：WO2012055814A1

  公开（公告）日：2012-05-03

  The present invention concerns a compound inducing Lyso-Bis Phosphatidic Acid (LPBA) accumulation in multi-vesicular bodies (MVB) of a cell for use for inhibiting i) cell-to-cell transmission of a Human Immunodeficiency Virus (HIV), and/or ii) entry of HIV into a cell, in an individual in need thereof. The invention further relates to products comprising a compound inducing LPBA accumulation in multi-vesicular bodies of a cell and an anti-HIV agent as combination products for simultaneous, sequential or separated use for the treatment and/or prevention of an infection with a HIV virus.