(2,4,5-Trichlorophenyl) 4-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]oxyethyl]-3-nitrobenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: (2,4,5-Trichlorophenyl) 4-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]oxyethyl]-3-nitrobenzoate
• 化学式: C₂₂H₂₁Cl₃N₂O₈
• 分子量: 547.776
• InChiKey: CFEURSIESWRJCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  BOC-甘氨酸 、 2,4,5-Trichlorophenyl 4'-(2-hydroxyethyl)-3'-nitrobenzoate 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以70%的产率得到(2,4,5-Trichlorophenyl) 4-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]oxyethyl]-3-nitrobenzoate
  参考文献：
  名称：

  Stepwise Solid-Phase Synthesis of the Nucleopeptide Phac-Phe-Val-Ser(p3'ACT)-Gly-OH

  摘要：

  The nucleopeptide Phac-Phe-Val-Ser(p(3')ACT)-Gly-OH, with a phosphodiester bond between the side chain hydroxyl group of a serine residue and the 3' end of a trinucleotide, has been synthesized by a stepwise procedure. The peptide was first assembled on an insoluble matrix and the oligonucleotide chain elongation was then carried out at the serine hydroxyl group of the resin-linked peptide by the phosphite triester approach using standard phosphoramidite derivatives. Mild basic conditions were used for the final deprotection of the permanent protecting groups.

  DOI：

  10.1021/jo00088a032

文献信息

• Stepwise Solid-Phase Synthesis of the Nucleopeptide Phac-Phe-Val-Ser(p3'ACT)-Gly-OH
  作者：Jordi Robles、Enrique Pedroso、Anna Grandas

  DOI：10.1021/jo00088a032

  日期：1994.5

  The nucleopeptide Phac-Phe-Val-Ser(p(3')ACT)-Gly-OH, with a phosphodiester bond between the side chain hydroxyl group of a serine residue and the 3' end of a trinucleotide, has been synthesized by a stepwise procedure. The peptide was first assembled on an insoluble matrix and the oligonucleotide chain elongation was then carried out at the serine hydroxyl group of the resin-linked peptide by the phosphite triester approach using standard phosphoramidite derivatives. Mild basic conditions were used for the final deprotection of the permanent protecting groups.