(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-amine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: (1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-amine
• 化学式: C₈H₁₆N₂
• 分子量: 140.23
• InChiKey: HJGMRAKQWLKWMH-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-氟吲哚啉 、 (1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-amine 生成 5-fluoro-N-[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2,3-dihydroindole-1-carboxamide
  参考文献：
  名称：

  BERMUDEZ, JOSE;DABBS, STEVEN;JOINER, KAREN A.;KING, FRANK D., J. MED. CHEM., 33,(1990) N, C. 1929-1932

  摘要：

  DOI：

文献信息

• BERMUDEZ, JOSE;FAKE, CHARLES S.;JOINER, GRAHAM F.;JOINER, KAREN A.;KING, +, J. MED. CHEM., 33,(1990) N, C. 1924-1929
  作者：BERMUDEZ, JOSE、FAKE, CHARLES S.、JOINER, GRAHAM F.、JOINER, KAREN A.、KING, +

  DOI：——

  日期：——
• BERMUDEZ, JOSE;DABBS, STEVEN;JOINER, KAREN A.;KING, FRANK D., J. MED. CHEM., 33,(1990) N, C. 1929-1932
  作者：BERMUDEZ, JOSE、DABBS, STEVEN、JOINER, KAREN A.、KING, FRANK D.

  DOI：——

  日期：——
• METHOD FOR PREDICTING THERAPEUTIC EFFECT OF LSD1 INHIBITOR BASED ON EXPRESSION OF INSM1
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20200190175A1

  公开（公告）日：2020-06-18

  A method for predicting a therapeutic effect of a chemotherapy using an antitumor agent comprising an LSD1 inhibitor in a cancer patient based on an expression level of INSM1 in a sample containing tumor cells isolated from the cancer patient.
• NOVEL BIPHENYL COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20210179634A1

  公开（公告）日：2021-06-17

  The present invention provides a compound represented by Formula (I) or a salt thereof; an LSD1 inhibitor that contains the compound or a salt thereof as an active ingredient; a pharmaceutical composition that contains the compound or a salt thereof; and an antitumor agent that contains the compound or a salt thereof as an active ingredient.