(2S,5R)-2-hydroxy-5,6-dihydro-3-methyl-2,5-diphenyl-2H-1,4-oxazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪类
• 英文名称: (2S,5R)-2-hydroxy-5,6-dihydro-3-methyl-2,5-diphenyl-2H-1,4-oxazine
• 英文别名: (3R,6S)-5-methyl-3,6-diphenyl-2,3-dihydro-1,4-oxazin-6-ol
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: JHWOVEJVQDPXIK-DLBZAZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  D-苯甘氨醇 、 1-苯基-1,2-丙二酮 以 四氢呋喃 为溶剂， 反应 15.0h， 以61%的产率得到(2S,5R)-2-hydroxy-5,6-dihydro-3-methyl-2,5-diphenyl-2H-1,4-oxazine
  参考文献：
  名称：

  Syntheses and Study of New 2-Hydroxy-5,6-Dihydro-2H-1,4-Oxazines by NMR and X-ray Crystallography

  摘要：

  The preparation of six new 2-hydroxy-5,6-dihydro-2H-[1,4]-oxazines and four oxazino-oxazine type structures is described. The structures of four of these compounds were established by X-ray crystallographic analyses.

  DOI：

  10.1080/00397910008086897

文献信息

• Syntheses and Study of New 2-Hydroxy-5,6-Dihydro-2H-1,4-Oxazines by NMR and X-ray Crystallography
  作者：Víctor Santes、Elizabeth Gómez、Griselda Jiménez、Rosa Santillan、Atilano Gutiérrez、Norberto Farfán

  DOI：10.1080/00397910008086897

  日期：2000.8

  The preparation of six new 2-hydroxy-5,6-dihydro-2H-[1,4]-oxazines and four oxazino-oxazine type structures is described. The structures of four of these compounds were established by X-ray crystallographic analyses.