2-trityl-[1,3,2]dioxaphospholane-2-oxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-trityl-[1,3,2]dioxaphospholane-2-oxide
• 英文别名: 2-Trityl-[1,3,2]dioxaphospholan-2-oxid；Tritylphosphonsaeure-aethandiylester；2-Trityl-1,3,2lambda5-dioxaphospholane 2-oxide；2-trityl-1,3,2λ5-dioxaphospholane 2-oxide
• 化学式: C₂₁H₁₉O₃P
• 分子量: 350.354
• InChiKey: SCYCCVWMCISGMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三苯基甲基溴 、 2-Benzyloxy-1,3,2-dioxaphospholan 生成 2-trityl-[1,3,2]dioxaphospholane-2-oxide
  参考文献：
  名称：

  Arbusow; Soroastrowa, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 536,541

  摘要：

  DOI：

文献信息

• The Complex Role of the Triphenylmethyl Motif in Anticancer Compounds
  作者：Rahul Palchaudhuri、Vitaliy Nesterenko、Paul J. Hergenrother

  DOI：10.1021/ja8020999

  日期：2008.8.1

  Compounds incorporating the triphenylmethyl motif constitute an emerging family of potent anticancer agents. Although several small molecules containing this pharmacophore have now been identified, the mechanism of cell death induction for some of these compounds is unknown. In an effort to define their mechanism of action, and to distinguish subtypes within the group of compounds containing the triphenylmethyl

  包含三苯甲基基序的化合物构成了一个新兴的强效抗癌剂家族。虽然现在已经鉴定了几种含有这种药效团的小分子，但其中一些化合物的细胞死亡诱导机制尚不清楚。为了确定它们的作用机制，并区分含有三苯甲基部分的化合物组中的亚型，我们创造了新的含有三苯甲基的小分子，并在一系列生物测定中对其进行了评估。在这里，我们展示了几种具有三苯甲基基序的膦酸盐和膦酰氯，可有效诱导培养中多种癌细胞系的死亡。评估导致细胞周期停滞、抑制微管蛋白聚合的能力的进一步分析，
• Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers
  申请人：Hergenrother Paul J.

  公开号：US20090004293A1

  公开（公告）日：2009-01-01

  Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.
• US7709465B2
  申请人：——

  公开号：US7709465B2

  公开（公告）日：2010-05-04
• [EN] PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS<br/>[FR] COMPOSÉS PHOSPHORÉS CONTENANT DES ESTERS DE TRIPHÉNYLMÉTHYLPHOSPHONATE POUR LE TRAITEMENT DU MÉLANOME ET D'AUTRES CANCERS
  申请人：UNIV ILLINOIS

  公开号：WO2007137200A2

  公开（公告）日：2007-11-29

  [EN] Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.
  [FR] L'invention concerne des composés et des méthodes associées de synthèse ainsi que l'utilisation de composés et de polythérapies dans le traitement du cancer et la modulation de l'apoptose dans des cellules. Cette invention concerne en particulier des esters de phosphonate. Ladite invention concerne en outre des composés, des procédés de production desdits composés, des médicaments et des procédés de production desdits médicaments ainsi que des méthodes thérapeutiques contre le cancer, y compris le cancer du sein, le mélanome, le cancer du colon, la leucémie et le lymphome, ainsi que d'autres cellules cancéreuses.