α,α,α',α'-tetrakis(1-trityl-4-imidazolyl)-2,6-pyridinedimethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: α,α,α',α'-tetrakis(1-trityl-4-imidazolyl)-2,6-pyridinedimethanol
• 英文别名: [6-[Hydroxy-bis(1-tritylimidazol-4-yl)methyl]pyridin-2-yl]-bis(1-tritylimidazol-4-yl)methanol
• 化学式: C₉₅H₇₃N₉O₂
• 分子量: 1372.68
• InChiKey: QTFQYCVHQDHSNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.1
• 重原子数：
  106
• 可旋转键数：
  22
• 环数：
  17.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  吡啶-2.6-二羧酸二甲酯 、 1-三苯甲基-4-碘咪唑 在 乙基溴化镁 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.0h， 以48%的产率得到α,α,α',α'-tetrakis(1-trityl-4-imidazolyl)-2,6-pyridinedimethanol
  参考文献：
  名称：

  A General Route to 4-Imidazolyl-Containing Multidentate Ligands for Biomimetic Studies

  摘要：

  [GRAPHICS]4-Iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignard reagent to give selectively the 4-magnesioimidazole derivative, which reacts with esters to form a variety of poly-4-imidazolyl carbinol compounds in 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featuring 4-substituted imidazole units have been efficiently synthesized.

  DOI：

  10.1021/ol990201b

文献信息

• A General Route to 4-Imidazolyl-Containing Multidentate Ligands for Biomimetic Studies
  作者：James P. Collman、Min Zhong、Zhong Wang

  DOI：10.1021/ol990201b

  日期：1999.9.1

  [GRAPHICS]4-Iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignard reagent to give selectively the 4-magnesioimidazole derivative, which reacts with esters to form a variety of poly-4-imidazolyl carbinol compounds in 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featuring 4-substituted imidazole units have been efficiently synthesized.