6-Ethyl-N2,N2-dimethyl-3,6-dihydro-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-Ethyl-N2,N2-dimethyl-3,6-dihydro-1,3,5-triazine-2,4-diamine
• 英文别名: 4-ethyl-6-N,6-N-dimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine
• 化学式: C₇H₁₅N₅
• 分子量: 169.23
• InChiKey: WCDFJUHZSMYSKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• DERIVES AMINES DE DIHYDRO-1,3,5-TRIAZINE ET LEURS APPLICATIONS EN THERAPEUTIQUE
  申请人：Merck Sante

  公开号：EP1250328B1

  公开（公告）日：2006-07-05
• Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses
  申请人：Moinet Gerard

  公开号：US20080108619A1

  公开（公告）日：2008-05-08

  The invention relates to the compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. These compounds can be used in the treatment of pathological conditions associated with the insulin-resistance syndrome.
• COMBINATION OF TRIAZINE DERIVATIVES AND HMG-COA REDUCTASE INHIBITORS
  申请人：Moinet Gérard

  公开号：US20100158999A1

  公开（公告）日：2010-06-24

  The present patent application relates to combinations of a triazine derivative with an HMG-CoA reductase inhibitor.
• COMBINATION OF TRIAZINE DERIVATIVES AND PPARalpha AGONISTS
  申请人：Moinet Gérard

  公开号：US20100159005A1

  公开（公告）日：2010-06-24

  The present patent application relates to combinations of triazine derivatives and of PPARα agonists.