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    首页 分子通 4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine;hydrochloride

    4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine;hydrochloride

    分子结构分类

    有机化合物 - 有机杂环化合物 - 吡咯并[3，4-d]哒嗪
    中文名称
    ——
    中文别名
    ——
    英文名称
    4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine;hydrochloride
    英文别名
    ——
    4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine;hydrochloride化学式
    CAS
    ——
    化学式
    C23H23ClN4O3
    mdl
    ——
    分子量
    438.9
    InChiKey
    VKRZQZBISXEZSB-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      4.64
    • 重原子数：
      31
    • 可旋转键数：
      6
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.22
    • 拓扑面积：
      70.4
    • 氢给体数：
      2
    • 氢受体数：
      6

    文献信息

    • [DE] NEUE PYRIDAZINO[4',5':3,4]PYRROLO-[2,1-a]ISOCHINOLINE UND DEREN VERWENDUNG FÜR DIE HERSTELLUNG VON PHARMAZEUTISCHEN ZUBEREITUNGEN<br/>[EN] NEW PYRIDAZINO[4',5':3,4]PYRROLO-[2,1-A]ISOQUINOLINES AND THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVELLES PYRIDAZINO[4',5':3,4]PYRROLO-[2,1-A]ISOQUINOLEINES ET LEUR UTILISATION POUR LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES
      申请人：BOEHRINGER INGELHEIM KG
      公开号：WO1995017402A1
      公开（公告）日：1995-06-29
      (DE) Die Erfindung betrifft neue pyridazino-[4',5':3,4]pyrrolo[2,1-a]-isochinoline der Formel (I) worin X, O, S oder NHO ist. Die neuen Verbindungen haben wertvolle therapeutisch nutzbare Eigenschaften. Sie sind als cardioprotektive Mittel, als hirnprotektive Mittel, als Mittel für die Behandlung chronisch inflammatorischer Prozesse, als Mittel mit antiproliferativer Wirkung und als Mittel zur Behandlung der Colitis Ulcerosa und des Morbus Crohn verwendbar.(EN) New pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinolines have formula (I), in which X stands for O, S or NHO. These new compounds have precious therapeutic properties. They are useful as heart and brain protective agents, as therapeutic agents for chronic inflammatory processes, as antiproliferative agents and as therapeutic agents for ulcerative colitis and Crohn's disease.(FR) L'invention concerne des nouvelles pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinoléines nouvelles ayant la formule (I), dans laquelle X désigne O, S ou NHO. Ces nouveaux composés ont de précieuses propriétés thérapeutiques. Ils sont utiles comme agents protecteurs du c÷ur et du cerveau, comme agents thérapeutiques de processus inflammatoires chroniques, comme agents à action anti-proliférative et comme agents thérapeutiques de la colite ulcéreuse et de la maladie de Crohn.
      这项发明涉及具有这种形式的新型吡咯[4',5':3,4]吡咯[2,1-a]-并咯啉化合物，其中X代表O、S或NHO。这些新的化合物具有非常宝贵的 therapeutic属性。他们可用于心脑保护、中枢神经保护、慢性炎症过程治疗、抗增殖作用以及溃疡性 colitis 和 Crohn 病治疗。
    查看更多

    同类化合物

    5,6,7-三甲基-2,6-二氢-1H-吡咯并[3,4-d]吡嗪-1-酮 1-氯-5,6,7-三甲基-6H-吡咯并[3,4-d]吡嗪盐酸盐 4-(5,7-dimethyl-1-oxo-2-phenyl-1H-pyrrolo[3,4-d]pyridazin-6(2H)-yl)butanoic acid 2,6-dihydro-2-methyl-4-(2-methylpropyl)-6-phenylmethyl-1H-pyrrolo[3,4-d]pyridazin-1-one 1-chloro-4-ethoxy-5,6,7-trimethyl-6H-pyrrolo<3,4-d>pyridazine 1,4-dichloro-5,6,7-trimethyl-6H-pyrrolo<3,4-d>pyridazine 1,4-dichloro-6-isopropyl-6H-pyrrolo[3,4-d]pyridazine ethyl 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methyl-6H-pyrrolo[3,4-d]pyridazine-5-carboxylate 1,2-dihydro-5,7-dimethyl-6H-pyrrolo<3,4-d>pyridazine-1-one 1,2-dihydro-2,5,7-trimethyl-6H-pyrrolo<3,4-d>pyridazine-1-one 1-ethoxy-5,6,7-trimethyl-6H-pyrrolo<3,4-d>pyridazine 2,8-dichloro-6-methylpyrrolo<1,2-b:3,4-d'>dipyridazin-5(6H)-one 5,6,7-trimethyl-6H-pyrrolo<3,4-d>pyridazine 1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazine 1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-ylamine 5,7-di-2-thienyl-2,3-dihydro-1H-pyrrolo[3,4-d]pyridazine-1,4(6H)-dione 2,3-dihydro-6H-pyrrolo[3,4-d]pyridazine-1,4-dione 5,7-dimethyl-6H-pyrrolo<3,4-d>pyridazine 1,2,3,4-tetrahydro-5,7-dimethyl-6H-pyrrolo<3,4-d>pyridazine-1,4-dione 5,10-Dihydro-2,3-dimethoxypyridazino<4',5':3,4>pyrrolo<2,1-a>isochinolin-9(6H)-on 6-Butyl-4-hydroxy-2,5,7-trimethyl-2,6-dihydro-pyrrolo[3,4-d]pyridazin-1-one 4-{5,7-Dimethyl-1-oxo-2-phenyl-1H,2H,6H-pyrrolo[3,4-D]pyridazin-6-YL}-N-(propan-2-YL)butanamide 2-{6-[(4-Fluorophenyl)methyl]-5,7-dimethyl-1-oxo-1H,2H,6H-pyrrolo[3,4-D]pyridazin-2-YL}-N-(4-methylcyclohexyl)acetamide N-[3-(Azepan-1-YL)propyl]-2-{5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-1H,2H,6H-pyrrolo[3,4-D]pyridazin-2-YL}acetamide N-[2-(Cyclohex-1-EN-1-YL)ethyl]-4-{5,7-dimethyl-1-oxo-2-phenyl-1H,2H,6H-pyrrolo[3,4-D]pyridazin-6-YL}butanamide (6E)-2-methoxy-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 8-chloro-6-methyl-2-(4-methylpiperidin-1-yl)pyrrolo[1,2-b:3,4-d']dipyridazin-5(6H)-one 6-(5-Ethoxypyrazin-2-yl)-1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazine 4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine;hydrochloride 6-[4-(4-Ethylpiperazin-1-YL)-4-oxobutyl]-5,7-dimethyl-2-phenyl-1H,2H,6H-pyrrolo[3,4-D]pyridazin-1-one N-benzyl-4-(5,7-dimethyl-4-oxo-3-phenylpyrrolo[3,4-d]pyridazin-6-yl)-N-methylbutanamide 6-[(1S)-1-(4-methoxyphenyl)ethyl]-1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazine 6-[(4-fluorophenyl)methyl]-5,7-dimethyl-2H-pyrrolo[3,4-d]pyridazin-1-one 4,5-dimethoxy-N-phenylmethoxy-10,14,15-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,4,6,11,13,15-heptaen-13-amine 4-(phenylhydrazinylidene)-2-[(Z)-(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)iminomethyl]cyclohexa-2,5-dien-1-one 4-(phenylhydrazinylidene)-2-[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)iminomethyl]cyclohexa-2,5-dien-1-one 2,4-dibromo-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 4-chloro-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 2-methoxy-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 4-bromo-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 2,4-dichloro-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 2-prop-2-enyl-6-[[(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)amino]methylidene]cyclohexa-2,4-dien-1-one 6-[1-(4-ethylpiperazin-1-yl)-1-oxopropan-2-yl]-5,7-dimethyl-2-phenyl-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one 2-{5,7-Dimethyl-1-oxo-2-phenyl-1H,2H,6H-pyrrolo[3,4-D]pyridazin-6-YL}-N-[(2-ethoxyphenyl)methyl]acetamide 2-(5,7-dimethyl-4-oxo-3-phenylpyrrolo[3,4-d]pyridazin-6-yl)-N-methylpropanamide 2-(6-benzyl-5,7-dimethyl-4-oxopyrrolo[3,4-d]pyridazin-3-yl)-N-methylacetamide 4-{5,7-Dimethyl-1-oxo-2-phenyl-1H,2H,6H-pyrrolo[3,4-D]pyridazin-6-YL}-N-(2-phenylethyl)butanamide 2-(5,7-dimethyl-4-oxo-3-phenylpyrrolo[3,4-d]pyridazin-6-yl)-N-propan-2-ylacetamide N,N-Diethyl-2-{6-[(2-fluorophenyl)methyl]-5,7-dimethyl-1-oxo-1H,2H,6H-pyrrolo[3,4-D]pyridazin-2-YL}acetamide

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