1,3-二氯-1,1,3,3-四乙基二硅氧烷 | 18825-03-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 1,3-二氯-1,1,3,3-四乙基二硅氧烷
• 英文名称: 1,3-Dichloro-1,1,3,3-tetraethyldisiloxane
• 英文别名: 1,3-Dichlor-tetraaethyl-disiloxan；1,3-Dichlortetraethyldisiloxan；1,1,3,3-tetraethyl-1,3-dichloro-disiloxane；1,1,3,3-Tetraaethyl-1,3-dichlor-disiloxan；Bis-(chlor-diaethyl-silyl)-aether；Chloro-[chloro(diethyl)silyl]oxy-diethylsilane
• CAS: 18825-03-1
• 化学式: C₈H₂₀Cl₂OSi₂
• 分子量: 259.323
• InChiKey: ZXLGILKATDDQDX-UHFFFAOYSA-N

物化性质

• 沸点：
  230.97°C (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  1,3-二氯-1,1,3,3-四乙基二硅氧烷 在 吡啶 、 水 、 苯胺 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 24.0h， 生成 dichloro-[[diethyl-[(2,4,4,6,6-pentaethyl-1,3,5,2,4,6-trioxatrisilinan-2-yl)oxy]silyl]oxy-diethylsilyl]oxy-ethylsilane
  参考文献：
  名称：

  Synthesis and some properties of functional linear and cyclic polyethylsiloxanes

  摘要：

  DOI：

  10.1007/bf00957159
• 作为产物：
  描述：

  boric acid tris-(diethyl-chloro-silanyl ester) 生成 1,3-二氯-1,1,3,3-四乙基二硅氧烷
  参考文献：
  名称：

  CCR3-Blocking Antibody Inhibits Allergen-Induced Eosinophil Recruitment in Human Skin Xenografts from Allergic Patients

  摘要：

  Eosinophil, basophil, and T helper 2 (TH2) cell recruitment into tissues is a characteristic feature of allergic diseases. These cells have in common the expression of the chemokine receptor CCR3, which may represent a specific pathway for their accumulation in vivo. Although animal models of allergic reactions are available, findings cannot always be extrapolated to man. To overcome these limitations, we have developed a humanized mouse model of allergic cutaneous reaction using severe combined immunodeficiency mice engrafted with skin and autologous peripheral blood mononuclear cells from allergic donors. Intradermal injection of the relevant allergen into human skin xenografts from allergic individuals induced a significant recruitment of human CD4(+) T cells, basophils, and TH2-type cytokine mRNA-expressing cells, as well as murine eosinophils. Human skin xenografts, atopic status, and autologous peripheral blood mononuclear cell reconstitution were all mandatory to induce the allergic reaction. Next, we addressed the role of CCR3 in the endogenous mechanisms involved in the inflammatory cell recruitment in this experimental model of allergic cutaneous reaction. In vivo administration of an anti-human CCR3-blocking antibody selectively reduced accumulation of eosinophils but not that of CD4(+) cells, basophils, or cells expressing mRNA for TH2-type cytokines. These findings establish a new in vivo model of humanized allergic reaction and suggest that eosinophil migration is mediated mainly through CCR3. Finally, these results suggest that this model might be useful to test human-specific antiallergic modulators.

  DOI：

  10.1097/01.lab.0000020417.13757.05

文献信息

• The fluorination of organochlorodisiloxanes
  作者：D. S. Payne

  DOI：10.1039/jr9540002143

  日期：——
• Reaction of aluminum chloride with dialkylcyclosiloxanes
  作者：A. A. Zhdanov、K. A. Andrianov、A. A. Bogdanova

  DOI：10.1007/bf01118748

  日期：1961.7
• Engelhardt,U.; Buenger,T., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1979, vol. 34, p. 1107 - 1111
  作者：Engelhardt,U.、Buenger,T.

  DOI：——

  日期：——
• 317. Alkyl, aryl, and alkoxy-derivatives of silicon tetrachloride and silicochloroform
  作者：H. J. Emeléus、S. R. Robinson

  DOI：10.1039/jr9470001592

  日期：——
• The Hydrolysis of Alkyl and Aryl Chlorosilanes. II. Rates and Mechanism of Hydrolysis in Homogeneous Solution
  作者：L. H. Shaffer、E. M. Flanigen

  DOI：10.1021/j150558a005

  日期：1957.12