(1R,5R)-3-methyl-3,8-diazabicyclo[3.2.1]octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: (1R,5R)-3-methyl-3,8-diazabicyclo[3.2.1]octane
• 化学式: C₇H₁₄N₂
• 分子量: 126.2
• InChiKey: OQMSHITZFTVBHN-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHENYLTETRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210387963A1

  公开（公告）日：2021-12-16

  Disclosed are phenyltetrazole derivatives of formula (I), wherein A, R 1 , R 2 , X, R′, R″, and n are as defined herein, and pharmaceutically acceptable salts thereof. Also disclosed are methods of using the phenyltetrazole derivatives for the treatment of diseases which can be influenced by inhibition of plasma kallikrein.