MeOEt(-2)[DMT(-5)]Lyxf(b)-thymin-1-yl

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: MeOEt(-2)[DMT(-5)]Lyxf(b)-thymin-1-yl
• 英文别名: 1-[(2R,3S,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C₃₄H₃₈N₂O₉
• 分子量: 618.7
• InChiKey: WIPCVBQXKBWNRC-SLWOLIQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  45
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150315229A1

  公开（公告）日：2015-11-05

  In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in Claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with columm-chromalographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

  在这种方法中，通过使用一种由式(I)所表示的新型核苷单体化合物作为合成单元来制备寡核苷酸。其中，X、R1、Y、Base、Z、Ar、R2、R3和n如权利要求1所定义。该新型核苷单体化合物是一种核苷，其碱基基团被取代了至少一个疏水基团的芳香烃环羰基或硫羰基。该方法不需要在每次反应中进行柱层析纯化，并且不仅可以在3'-方向上进行碱基延伸，还可以在5'-方向上进行碱基延伸，从而实现寡核苷酸的高效液相大规模合成。
• Method for liquid-phase synthesis of nucleic acid
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10730904B2

  公开（公告）日：2020-08-04

  In this method, an oligonucleotide represented by formula (II) [wherein Y1, Q, Base, r and r′ are each as defined in claim 1] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

  在该方法中，使用式(I)代表的新型核苷单体化合物[其中X、R1、Y、Base、Z、Ar、R2、R3和n各自如权利要求1中定义]作为合成单元，制备式(II)代表的寡核苷酸[其中Y1、Q、Base、r和r′各自如权利要求1中定义]。新型核苷单体化合物是一种核苷，其碱基被具有至少一个疏水基团的芳香-烃环-羰基或-硫代羰基取代。该方法在每个反应中都无需柱色谱纯化，不仅可以在 3′方向上进行碱基延伸，还可以在 5′方向上进行碱基延伸，从而实现寡核苷酸的高效液相大规模合成。
• METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACIDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2921499B1

  公开（公告）日：2020-01-22