1-{[2-(二乙基氨基)乙基]氨基}-4-(羟基甲基)-9H-噻吨-9-酮甲烷磺酸盐(1:1) | 30922-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 中文名称: 1-{[2-(二乙基氨基)乙基]氨基}-4-(羟基甲基)-9H-噻吨-9-酮甲烷磺酸盐(1:1)
• 英文名称: (1-{[2-(Diethylamino)ethyl]amino}-9-oxo-9h-thioxanthen-4-yl)methyl methanesulfonate
• 英文别名: [1-[2-(diethylamino)ethylamino]-9-oxothioxanthen-4-yl]methyl methanesulfonate
• CAS: 30922-68-0
• 化学式: C₂₁H₂₆N₂O₄S₂
• 分子量: 434.6
• InChiKey: YYOFXKOUMJOLIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Formulation for increasing the weight of livestock, comprising an ionophore and selenium
  申请人：ELI LILLY AND COMPANY

  公开号：EP0671174A2

  公开（公告）日：1995-09-13

  This invention relates to a formulation for increasing weight of livestock comprising an ionophore, selenium and a veterinary acceptable carrier, diluent, excipient and/or adjuvant. The invention also relates to a method of increasing liveweight gain in livestock comprising, administering to said livestock an effective amount of a formulation of the invention. The invention further relates to a method of increasing selenium absorption in livestock comprising, administering to said livestock an effective amount of an ionophore.

  本发明涉及一种用于增加家畜体重的制剂，该制剂由离子体、硒和兽医可接受的载体、稀释剂、赋形剂和/或佐剂组成。本发明还涉及一种增加家畜活重的方法，包括向所述家畜施用有效量的本发明制剂。本发明还涉及一种增加家畜硒吸收的方法，包括向所述家畜施用有效量的离子发酵剂。
• Dosage form, device, and methods of treatment
  申请人：Lowe Barry Lionel

  公开号：US20050064032A1

  公开（公告）日：2005-03-24

  The present invention relates to a controlled dosage release element adapted to be inserted into and retained in the rumen of a ruminant animal. The element comprises: a) one or more discrete and predetermined amounts of at least a first formulation comprising at least a first active agent, the formulation being adapted to dissolve in rumen fluids at a rate such that dissolution of each of the one or more amounts of first formulation provides a short or pulsed episode of release of the first active agent into the rumen; and b) one or more predetermined amounts of at least a second formulation adapted to dissolve at a controlled rate in rumen fluids; wherein the one or more amounts of first formulation are provided at one or more predetermined locations within the element relative to said one or more amounts of second formulation for one or more delayed releases of at least the first active agent into the rumen at predetermined times before, during, after, or any combination thereof, of a predetermined extended time period defined by said second formulation. The invention also relates to a method for delivering at least a first active agent to the rumen of a ruminant animal in a delayed manner at one or more predetermined times after administration to the animal of a composition containing the active agent, the method comprising administering to the animal a controlled dosage release element according to the invention. The first active agent will typically be for the treatment, prophylaxis or both of a diseased or infested state in a ruminant animal, or for altering the physiological status of a ruminant animal.

  本发明涉及一种可插入反刍动物瘤胃并保留在其中的控释元件。该元件包括a) 一种或多种离散和预定量的至少包含第一种活性剂的第一制剂，该制剂在瘤胃液中的溶解速率使第一制剂的每一种或多种量的溶解都能将第一种活性剂短时间或脉冲式地释放到瘤胃中；以及 b) 一种或多种预定量的至少包含第二种制剂的制剂，该制剂在瘤胃液中的溶解速率受控；其中，相对于所述一个或多个量的第二制剂，在元件内的一个或多个预定位置提供一个或多个量的第一制剂，以便在所述第二制剂确定的预定延长时间段之前、期间、之后或其任意组合的预定时间段内，将至少第一活性剂延迟释放到瘤胃中。本发明还涉及一种方法，用于在向反刍动物施用含有活性剂的组合物后，在一个或多个预定时间内，以延迟的方式将至少第一种活性剂输送到反刍动物的瘤胃中，该方法包括向动物施用根据本发明的控释剂。第一种活性剂通常用于治疗、预防或治疗反刍动物的疾病或感染状态，或用于改变反刍动物的生理状态。
• Sustained release capsule and formulations for insertion into rumen
  申请人：ELI LILLY AND COMPANY

  公开号：EP0507629B1

  公开（公告）日：1997-01-22
• DOSAGE FORM, DEVICE AND METHODS OF TREATMENT
  申请人：ELI LILLY AND COMPANY

  公开号：EP1448151A1

  公开（公告）日：2004-08-25
• US5178857A
  申请人：——

  公开号：US5178857A

  公开（公告）日：1993-01-12